Toggle Health Problems and D

Vitamin D Receptor

  1. It appears that 1/3 of everyone with a vitamin D-related disease has a poor VDR
  2. A poor VDR cannot be detected by any standard Vitamin D test (Calcitriol or Calcidiol)
  3. A poor Parathyroid VDR can be detected when high Calcitriol levels fail to decrease PTH levels
  4. Many cancers and viruses have learned to protect themselves by deactivating the local VDR
  5. A VDR activation decreases with age

Vitamin D Receptor Overview

517 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (36 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

How to increase VDR activation

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14) Butyrate especially gutVitamin D Receptor
15) BerberineVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

Increased risk associated with a poor Vitamin D Receptor
   Note: Some diseases reduce VDR activation
those with a * are known to decrease activation

Health Problem
50Lyme Disease *
28Leprosy - another says 3X
15Chronic Heart Failure
15Temporary hair loss
14,7Childhood solid cancers
14Hand, Foot, and Mouth disease
12COVID Death
11Metabolic Syndrome
9.6Chronic Periodontitis
   and smoke
8Juvenile Rheumatoid Arthritis
7.6Crohn's disease
7.5Respiratory Tract Infections
5.8Low back pain in athletes
5 Respiratory Distress in preemies
5Ulcerative Colitis
5Coronary Artery Disease
5Asthma Child see also 1.3, 2.0 and 3.6
4.6Breast Cancer * 16.9 X another study
4.3Severe COVID in kids
4Polycystic ovary syndrome
3.6 Pneumonia - children
3.3 Pre-term birth
3.1 Colon Cancer survival
3 Multiple Sclerosis
3 Waist size
3 Ischemic Stroke
9X in women
3Gestational Diabetes
2.9Hand, Foot, Mouth Disease
2.8Osteoporosis & COPD
2.7Gastric Cancer
2.6Lupus in children
2.5 Lumbar Disc Degeneration
2.4Lung Cancer
2.2Juvenile idiopathic arthritis
2.1Adolescent idiopathic scoliosis in Asians
2Diabetic Retinopathy
2 Wheezing/Asthma see also 5X
2 Melanoma   Non-melanoma Skin Cancers
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.8Sleep Apnea
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.4Graves Disease
1.4 Rheumatoid arthritis
1.3Childhood asthma see also 5X
1.3Psoriasis in Caucasians
?? Rickets - Vitamin D resistant

VitaminDWiki - Vitamin D Receptor activation can be increased in 16 ways

Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin,   Berberine,  intense exercise, Butyrate   Sulforaphane   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 16 known VDR activators

Google Scholar has 30,900+ results for many the above VDR activators

  • Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin - 2016 Mar FREE PDF
  • Exercise acutely increases vitamin D receptor expression in T lymphocytes in vitamin D-deficient men, independent of age- April 2021 FREE PDF
  • Quercetin activates vitamin D receptor and ameliorates breast cancer-induced hepatic inflammation and fibrosis - April 2023 FREE PDF
  • Natural Epigenetic Modulators of Vitamin D Receptor -June 2020 FREE PDF

Did not notice any studies that indicated how much of the activator is needed

VitaminDWiki - 39 Meta-analyses of the Vitamin D Receptor

This list is automatically updated

Explosive increase in Quercetin medical publications as of 2022

Quercetin in PubMed

  • Epigenetic regulation by quercetin: a comprehensive review focused on its biological mechanisms 2023 Dec doi: 10.1080/10408398.2023.2278760. PDF behind paywall
  • Research progress of quercetin in cardiovascular disease Nov 2023 10.3389/fcvm.2023.1203713 FREE PDF
  • Quercetin and metabolic syndrome: A review - Oct 2021 doi: 10.1002/ptr.7144 $15 paywall
  • Potential Implications of Quercetin in Autoimmune Diseases 2021 Jun doi: 10.3389/fimmu.2021.689044 FREE PDF
  • Quercetin activates vitamin D receptor and ameliorates breast cancer induced hepatic inflammation and fibrosis 2023 April 10.3389/fnut.2023.1158633  PDF

11+ VitaminDWiki pages with QUERCETIN in the title

This list is automatically updated

18+ VitaminDWiki pages with CURCUMIN in the title

This list is automatically updated

VitaminDWiki has 86+ VDR pages with Cancer in the title - as of April 2024

Book: Sunlight, UV, Vitamin D and Receptor, Skin and Other Cancers - Dec 2020

Book: Sunlight, UV, Vitamin D and Receptor, Skin and other Cancers - Dec 2020
 Download the VDR chapter from sci-hub via VitaminDWiki
Has the risk of Breast Cancer due to poor Vitamin D Receptors increased in past decades?

Genetics category listing contains the following

334 articles in the Genetics category

see also

Vitamin D blood test misses a lot
in Visio for 2023

  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)   Commercially available 2019
    • However, test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
        especially if it is one of 51+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
    3) DNA and VDR tests - 120 to 200 dollars $100 to $250
    4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)
       Genes are good, have enough Magnesium, etc.
    5) Back Pain
       probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
      • The founder of VitaminDWiki took action with clues #3&5

517 VDR items

See also Vitamin D Binding Protein category listing has 177 items

In addition to inherited poor VDR genes, Herpes downregulates VDR by 8X for a short time

Note: Many people have Herpes but are not aware of it. (example: 48% of black women)

See also web

  • Natural Ways to Increase Calcitriol and Activate The Vitamin D Receptor Gene Selfhacked Jan 2016 - has lots of linked references
    Includes Exercise, RXR ( and retinol) is needed to produce proteins with the VDR, SIRT1 -potentiates VDR, PGC-1a, Dopamine
    Bile, Omega-3: Omega-6:Curcumin, Resveratrol, Forskolin , Gamma Tocotrienol, Estradiol,
    What Inhibits The Vitamin D Receptor (VDR) or Calcitriol
    Caffeine, Cortisol/Glucocorticoids, Prolactin, Thyroid hormones, Corticosteroids decrease calcitriol, Phosphatonin, Ketoconazole, Heparin and Thiazides decrease
    Pathogens That Inhibit The Vitamin D Receptor include
    P. aeruginosa, H. pylori, Lyme/Borrelia – Live Borrelia reduces VDR by 50 times (in monocytes).
    Tuberculosis – Reduces VDR 3.3-fold.“Gliding” biofilm bacteria, Shigella, Mycobacterium leprase
    Epstein-Barr virus (EBV) – Decreases VDR by a factor of about five, HIV – binds to the VDR (R) and inhibits conversion to active D
    Aspergillus fumigatus – In cystic fibrosis patients,
    Cytomegalovirus – CMV decreases VDR 2.2 fold, Hepatitis C virus – Inhibits CYP24A1|Changes in vitamin D endocrinology during aging in adults] June 2017
  • Changes in vitamin D endocrinology during aging in adults June 2017
  • "Aging leads to a decrease in vitamin D receptor number in several organs."
    Interesting, details are behind a paywall
  • Bioinformatic approaches to interrogating vitamin D receptor signaling - Sept 2017
     Download the PDF from VitaminDWiki
  • Calcitriol receptor = VDR Wikipedia
    "Glucocorticoids are known to decrease expression of VDR,"
    "Mutations in this gene are associated with type II vitamin D-resistant rickets"
    "The vitamin D receptor plays an important role in regulating the hair cycle."
  • Learn more about Calcitriol Receptor Science Direct.COM
    10 abstracts of book chapters and studies
  • Calcitriol ReceptorWikipedia
    "Mutations in this gene are associated with type II vitamin D-resistant rickets"
    "Calcitriol, the active form of vitamin D, binds to the VDR, which then forms a heterodimer with the retinoid-X receptor"
        perhaps this is where Vitamin A is important with Vitamin D
    "Glucocorticoids are known to decrease expression of VDR"

Chart: Need more D if poor VDR (ignores VDR activation and loading dose) - Sept 2021

1 minute video description of the chart


Light activates VDR at conception,etc. - April 2017
VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences.
Am J Hum Biol. 2017 Apr 22. doi: 10.1002/ajhb.23010
Beckett EL1,2,3, Jones P1, Veysey M2,4, Duesing K3, Martin C1, Furst J5, Yates Z6, Jablonski NG7, Chaplin G7, Lucock M1.

The vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. We examined whether degree of VDR gene methylation acts as a molecular adaptation to light exposure. We explored this in the context of photoperiod at conception, recent UV irradiance at 305 nm, and gene-latitude effects.

Eighty subjects were examined for VDR gene-CpG island methylation density. VDR gene variants were also examined by PCR-RFLP.

Photoperiod at conception was significantly positively related to VDR methylation density, explaining 17% of the variance in methylation (r2  = 0.17; P = .001). Within this model, photoperiod at conception and plasma 25(OH)D independently predicted methylation density at the VDR-CpG island. Recent UV exposure at 305 nm led to a fivefold increase in mean methylation density (P = .02). Again, UV exposure and plasma 25(OH)D independently predicted methylation density at the VDR-CpG island. In the presence of the BsmI mutant allele, methylation density was increased (P = .01), and in the presence of the TaqI or FokI mutant allele, methylation density was decreased (P = .007 and .04 respectively). Multivariate modeling suggests plasma 25(OH)D, photoperiod at conception, recent solar irradiance, and VDR genotype combine as independent predictors of methylation at the VDR-CpG island, explaining 34% of the variance in methylation (R2  = 0.34, P < .0001).

Duration of early-life light exposure and strength of recent irradiance, along with latitudinal genetic factors, influence degree of VDR gene methylation consistent with this epigenetic phenomenon being a molecular adaptation to variation in ambient light exposure. Findings contribute to our understanding of human biology.
Publisher rents PDF for $6

More and more PubMed papers on Vitamin D Receptor

Ways to increase the VDR - Selfhacked

Vitamin D Receptor Gene: Ways to Activate it, Calcitriol, Benefits Self-hacked.com Aug 2018
A list of ways to Increase EITHER active Vitamin D or Vitamin D Receptor
Following subset list May include some non-VDR items by mistake
See self-hacked article for hyperlinks and details

  • RXR (and retinol) is needed to produce proteins with the VDR. 1,25D3 binds to the VDR, which then combines with RXR to activate gene expression. (Not all VDR-dependent genes need RXR.)
  • SIRT1 -potentiates VDR [R, R] – acetylation of VDR lessens 1,25D/VDR signaling. SIRT1 increased the ability of VDR to associate with RXR.
  • PGC-1a [R]– potentiates VDR. It is a coactivator of the VDR, but it still needs 1,25D3.
  • Dopamine [R]
  • The VDR evolved from its ancient role as a detoxification nuclear receptor. LCA is produced from the gut bacteria (metabolizing liver-derived chenodeoxycholic acid). LCA travels to the colon, where the VDR binds to LCA or 1,25 D and activates the CYP3A4 and SULT2A genes facilitate disposal from the cell via the ABC efflux transporter [R].
  • Omega-3: DHA, EPA [R], – Fish oil/DHA
  • Omega-6: γ-Linolenic acid, Arachidonic acid [R],
  • Curcumin [R]– Curcumin is more active than LCA/Bile in driving VDR-mediated transcription and that it binds to VDR with approximately the same affinity as LCA.
  • Resveratrol [R] – Potentiates VDR by: (1) potentiating 1,25D binding to VDR; (2) activating RXR; (3) stimulating SIRT1.
  • Gamma Tocotrienol [R]- Tocotrienols or Tocopherols (IHERB)
  • Estradiol increases VDR expression [R, R] and calcitriol levels [R].

Many VDR test kits can be used ELISA and other testers


VDR category is associated with these 49 other VitaminDWiki categories

Genetics 74, Binding Protein 46, Virus 33, CYP27B1 32, Pregnancy 24, Breathing 24, Diabetes 23, Cancer 22, Infant-Child 21, Cancer - Breast 19, Autoimmune 18, Resveratrol 18, Cognitive 16, Obesity 16, Osteoporosis 13, Cancer - Colon 13, Gut 13, Immunity 12, Parkinson 11, Cancer - Other 11, Seniors 10, Rheumatoid Arthritis 10, Cancer - Skin 10, Multiple Sclerosis 10, Hypertension 9, Vision 8, Tuberculosis 8, Skin 7, Thyroid 7, Skin - Dark 7, Cancer - Prostate 7, Back pain 7, Fertility and sperm 6, Dental 6, Women 6, Cancer - Ovarian 6, Bone - Health 6, Sports 6, Cardiovascular 6, Lupus 6, Cancer - after diagnosis 5, UV 5, Liver 5, Intervention 4, Autism 4, Deficiency 4, Books & videos 4, Mortality 4, Stroke 4, Middle East 4, Kidney 4, Cancer - Lung 4, Cancer - Bladder 4

Details of associations with the VDR category

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Attached files

ID Name Comment Uploaded Size Downloads
20457 Quercetin VDR_CompressPdf.pdf admin 09 Dec, 2023 559.59 Kb 81
20456 Quercetin publications.png admin 09 Dec, 2023 280.14 Kb 879
18471 VDR gene mutation.jpg admin 23 Sep, 2022 59.62 Kb 3588
14794 BC VDR increase.jpg admin 31 Dec, 2020 106.31 Kb 12002
14793 BC VDR increase.jpg admin 31 Dec, 2020 106.31 Kb 261
14792 VDR chapter from 2020 book.pdf admin 31 Dec, 2020 551.47 Kb 742
11634 VDR Heart failure Sci-Hub.pdf admin 23 Mar, 2019 139.57 Kb 1007
11245 VDR PubMed 2018.jpg admin 23 Jan, 2019 4.22 Kb 14489
9087 Bioinformatic VDR.pdf admin 31 Dec, 2017 490.24 Kb 1445
8975 Gyn Cancers.pdf admin 20 Dec, 2017 728.42 Kb 1414
8536 Vitamin D receptor-targeted treatment to prevent - - Diabetes.pdf admin 11 Oct, 2017 6.46 Mb 1435
7458 VDR papers.jpg admin 06 Dec, 2016 4.32 Kb 4009