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Vitamin D Receptor

209 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

A poor VDR increases the risk of 41 health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor


See chart at the bottom of VDR page for Magnesium, Omega-3 and Resveratrol

If poor Vitamin D Receptor

Risk
increase
Health Problem
28Leprosy
13Sepsis
9.6Chronic Periodontitis
   and smoke
7.6Crohn's disease
7.5Respiratory Tract Infections
5.8Low back pain in athletes
5Ulcerative Colitis
5Coronary Artery Disease
4.6Breast Cancer
4polycystic ovary syndrome
3.3 Pre-term birth
3.1 Colon Cancer survival
3 Multiple Sclerosis
3Dengue
3 Waist size
3 Ischemic Stroke
3Alzheimer’s
2.8Osteoporosis & COPD
2.7Gastric Cancer
2.6Lupus in children
2.5 Lumbar Disc Degeneration
2.4Lung Cancer
2.3Autism
2.1Adolescent idiopathic scoliosis in Asians
2Diabetic Retinopathy
2Parkinson's
2 Wheezing/Asthma
2 Melanoma   Non-melanoma Skin Cancers
2Myopia
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.5Pertusus
1.5Obesity
1.4 Rheumatoid arthritis
1.3Childhood asthma
1.3Tuberculosis


Parkinson’s risk increased. . . has the following

FokI T > C rs 10735810
BsmI A > G rs 1544410
ApaI A > C rs 7975232
TaqI C > T rs 731236
none of these appear to be in the DNA test service 23andMe

20 Most-visited pages in VitaminD Receptor category

Id Page Hits Last modification Creator Categories
3439 Genetics 28697
28 Mar, 2018 20:10
ricks99 Genetics
Vitamin D Receptor
Vit D Binding Protein
Category
6760 Vitamin D Receptor 16575
08 May, 2018 13:33
admin Vitamin D Receptor
Category
3335 Vitamin D levels are strongly associated with genes: overview of twin studies – Nov 2012 12126
04 Jan, 2015 02:37
admin Genetics
Vitamin D Receptor
7065 Vitamin D and the skin: Focus on a complex relationship - Nov 2015 11387
15 May, 2017 00:00
admin Top news
Skin
Vitamin D Receptor
794 229 Genes related to vitamin D - Aug 2010 8695
08 Jan, 2015 16:24
admin Deficiency of Vitamin D
Overview for doctors
Vitamin D Receptor
4216 The vitamin D receptor and T cell function – June 2013 8676
11 May, 2017 00:50
admin Immunity
Vitamin D Receptor
3881 Vitamin D level can be high, but little benefit: due to kidney, genes, low Magnesium etc. 8264
28 Nov, 2014 19:11
admin Deficiency of Vitamin D
How much Vitamin D
Kidney
Vitamin D and Magnesium
Genetics
Top news
Vitamin D Receptor
Vit D Binding Protein
3976 Vitamin D is suppressed by both Roundup and Genes 7196
25 Oct, 2017 15:43
admin Vitamin D Receptor
Glyphosate
5287 10 reasons why seniors need more vitamin D 6876
12 Aug, 2017 15:50
admin Seniors
Top news
Vitamin D Receptor
7403 Health problems that run in families are often associated with low vitamin D 6835
13 Feb, 2018 23:52
admin Health
Genetics
Top news
Vitamin D Receptor
Vit D Binding Protein
6872 Intensely exercising muscles (rats) increases their vitamin D reception capability.– Sept 2015 6713
17 Oct, 2015 16:30
admin Sports and Vitamin D
Vitamin D Receptor
6306 Growth Hormone problem (Acromegaly) more likely if vitamin D gene problems problems – 2015 6205
15 May, 2018 09:58
admin Vitamin D Receptor
Vit D Binding Protein
5564 Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014 5799
23 Sep, 2016 13:30
admin Parkinson
Meta-analysis of Vitamin D
Cognitive
Vitamin D Receptor
4887 Vitamin D receptor may suppress skin cancer – Dec 2013 5560
27 Jan, 2017 18:43
admin Cancer - Skin
Vitamin D Receptor
5739 2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis Aug 2014 5463
26 Oct, 2016 15:50
admin Parkinson
Meta-analysis of Vitamin D
Top news
Vitamin D Receptor
5641 Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014 5432
25 Jul, 2017 16:06
admin Cancer - Pancreatic
Genetics
Top news
Vitamin D Receptor
4983 Vitamin D Receptor role in Autoimmune Diseases and or cancers – Nov 2013 5272
28 Oct, 2017 11:25
admin Autoimmune
Cancer
Genetics
Vitamin D Receptor
3490 Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012 5217
05 Dec, 2016 16:09
admin Skin - Dark
Osteoporosis
Genetics
Meta-analysis of Vitamin D
Vitamin D Receptor
3699 Calcium and vitamin D receptors are important to many health conditions – Jan 2013 5124
14 Nov, 2016 02:34
admin Health
Vitamin D and Calcium
Vitamin D Receptor
2651 10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012 4719
23 Sep, 2016 14:33
admin Cancer - Colon
Meta-analysis of Vitamin D
Vitamin D Receptor

Genetics category listing contains the following

212 articles in Genetics the category

 

see also 209 articles in Vitamin D Receptor, 84 articles in Vitamin D Binding Protein

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by VitaminDWiki - (subject to many future developments)
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, andi in 2017 is speculated to be 90%
  • Note: Good results from a blood test (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells appears feasible (personal communication)
    However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
       especially if it is one of 37+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are poor
    4) Back Pain
        probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
          The founder of VitaminDWiki took action with clues #3&4

Additional information on the Genes in VitaminDWiki

Gene# of pages
Oct 2017
Location
CYP27A1223 Liver
CYP2R1 626Tissue
Vitamin D Binding Protein
GC
3,450 Blood
CYP27B1803Kidney & Tissue
Vitamin D Receptor 6,030Cell Tissue
CYP24A1 745 excrete excess


See also Vitamin D Binding Protein category listing has 84 items


In addition to inherited poor VDR genes, Herpes downregulates VDR by 8X for a short time

Note: Many people have Herpes but are not aware of it. (example: 48% of black women)

See also web

  • Natural Ways to Increase Calcitriol and Activate The Vitamin D Receptor Gene Selfhacked Jan 2016 - has lots of linked references
    Includes Exercise, RXR ( and retinol) is needed to produce proteins with the VDR, SIRT1 -potentiates VDR, PGC-1a, Dopamine
    Bile, Omega-3: Omega-6:Curcumin, Resveratrol, Forskolin , Gamma Tocotrienol, Estradiol,
    What Inhibits The Vitamin D Receptor (VDR) or Calcitriol
    Caffeine , Cortisol/Glucocorticoids, Prolactin, Thyroid hormones,Corticosteroids decrease calcitriol,Phosphatonin, Ketoconazole, Heparin and Thiazides decrease
    Pathogens That Inhibit The Vitamin D Receptor include
    P. aeruginosa, H. pylori, Lyme/Borrelia – Live Borrelia reduces VDR by 50 times (in monocytes).
    Tuberculosis – Reduces VDR 3.3-fold.“Gliding” biofilm bacteria, Shigella, Mycobacterium leprase
    Epstein-Barr virus (EBV) – Decreases VDR by a factor of about five, HIV – binds to the VDR (R) and inhibits conversion to active D
    Aspergillus fumigatus – In cystic fibrosis patients,
    Cytomegalovirus – CMV decreases VDR 2.2 fold, Hepatitis C virus – Inhibits CYP24A1|Changes in vitamin D endocrinology during aging in adults] June 2017
  • Changes in vitamin D endocrinology during aging in adults June 2017
  • "Aging leads to a decrease in vitamin D receptor number in several organs."
    Interesting, details are behind a paywall
  • Bioinformatic approaches to interrogating vitamin D receptor signaling - Sept 2017
     Download the PDF from VitaminDWiki
  • Calcitriol receptor = VDR Wikipedia
    "Glucocorticoids are known to decrease expression of VDR,"
    "Mutations in this gene are associated with type II vitamin D-resistant rickets"
    "The vitamin D receptor plays an important role in regulating the hair cycle."

PubMed

Light activates VDR at conception,etc. - April 2017
VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences.
Am J Hum Biol. 2017 Apr 22. doi: 10.1002/ajhb.23010. [Epub ahead of print]
Beckett EL1,2,3, Jones P1, Veysey M2,4, Duesing K3, Martin C1, Furst J5, Yates Z6, Jablonski NG7, Chaplin G7, Lucock M1.

OBJECTIVES:
The vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. We examined whether degree of VDR gene methylation acts as a molecular adaptation to light exposure. We explored this in the context of photoperiod at conception, recent UV irradiance at 305 nm, and gene-latitude effects.

METHODS:
Eighty subjects were examined for VDR gene-CpG island methylation density. VDR gene variants were also examined by PCR-RFLP.

RESULTS:
Photoperiod at conception was significantly positively related to VDR methylation density, explaining 17% of the variance in methylation (r2  = 0.17; P = .001). Within this model, photoperiod at conception and plasma 25(OH)D independently predicted methylation density at the VDR-CpG island. Recent UV exposure at 305 nm led to a fivefold increase in mean methylation density (P = .02). Again, UV exposure and plasma 25(OH)D independently predicted methylation density at the VDR-CpG island. In the presence of the BsmI mutant allele, methylation density was increased (P = .01), and in the presence of the TaqI or FokI mutant allele, methylation density was decreased (P = .007 and .04 respectively). Multivariate modelling suggests plasma 25(OH)D, photoperiod at conception, recent solar irradiance, and VDR genotype combine as independent predictors of methylation at the VDR-CpG island, explaining 34% of the variance in methylation (R2  = 0.34, P < .0001).

CONCLUSIONS:
Duration of early-life light exposure and strength of recent irradiance, along with latitudinal genetic factors, influence degree of VDR gene methylation consistent with this epigenetic phenomenon being a molecular adaptation to variation in ambient light exposure. Findings contribute to our understanding of human biology.

PMID: 28432711 DOI: 10.1002/ajhb.23010
Publisher rents PDF for $6


Big increase in PubMed papers with Vitamin D Receptor or VDR in the title
Image
2,987 studies had Vitamin D Receptor in the title as of Nov 2017
191 VDR studies added in 2017 (as of Nov)


Short URL = is.gd/VitDReceptor

Vitamin D Receptor        

16699 visitors, last modified 08 May, 2018, URL:

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ID Name Comment Uploaded Size Downloads
9087 Bioinformatic VDR.pdf PDF 2017 admin 31 Dec, 2017 23:29 490.24 Kb 67
8975 Gyn Cancers.pdf admin 20 Dec, 2017 22:14 728.42 Kb 89
8536 Vitamin D receptor-targeted treatment to prevent - - Diabetes.pdf PDF 2017 admin 11 Oct, 2017 20:14 6.46 Mb 196
7458 VDR papers.jpg admin 06 Dec, 2016 03:34 4.32 Kb 2290
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