Am J Epidemiol. 2019 Jan 4. doi: 10.1093/aje/kwy285.
O'Brien KM1,2, Sandler DP1, House M3, Taylor JA1, Weinberg CR2.
1 Epidemiology Branch, National Institutes of Environmental Health Sciences.
2 Biostatistics and Computational Biology Branch, National Institute of Enviro, Health Sciences.
3 Westat, Inc., Durham, NC.
- The women had sisters who had gotten breast cancer and were in a study analyzing the association between Vitamin D and breast cancer
- Vitamin D Test #1, They did/did not get Breast Cancer, Vitamin D Test #2
|Test #1||Test #2 |
4-10 years later)
|Breast Cancer risk|
per +10 ng of Vit D
|No Breast Cancer||32 ng||40 ng||-13%|
|Breast Cancer||32 ng||44 ng||+17%|
Note: Increasing Vitamin D for just a few years does not decrease the chance of breast cancer,
but will increase survival
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Vitamin D and breast cancer radiation
- Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
- Vitamin D reduces the risk of Breast Cancer, improves treatment, and improves survival
- Breast Cancer treatment outcome might be predictable from Vitamin D test results – trial 2024
Genes can restrict how much Vitamin D acually gets to tissues (Breast Cancer Cells)
- Breast Cancer incidence change by 40 percent with vitamin D receptor genes – Oct 2012
- Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018
- Breast Cancer was 4.6 times more likely if have a poor Vitamin D Receptor – Dec 2016
- Increased Breast Cancer metastasis if low vitamin D or poor VDR – Feb 2016
- Note: Resveratrol etc, increases how much vitamin D actually gets to cells
A strategy of Breast Cancer cells is to decrease Vitamin D it gets
contains the following
- 16+ meta-analyses of Vitamin D and Breast Cancer
example: 2X reduction of deaths from Breast Cancer if have enough Vitamin D.
- Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer
wonder just how much more proof is needed
- Breast Cancer 4X more likely if have poor genes
- Cancer - Breast category listing has
222 items along with related searches
Prospective and retrospective studies of vitamin D and breast cancer have produced discrepant results. This may be due to variations in serum 25-hydroxyvitamin D [25(OH)D] concentrations over time, including systematic changes after breast cancer diagnosis. We measured total serum 25(OH)D in Sister Study participants who provided samples at baseline (2003-2009) and 4-10 years later (2013-2015). This included 827 women with an intervening breast cancer and 771 without. Although modestly correlated over time (R=0.42), 25(OH)D concentrations increased in both groups, with larger increases among cases (averaging 31.6 ng/mL at baseline, 43.5 ng/mL at follow-up) than controls (32.3 ng/mL at baseline, 40.4 ng/mL at follow-up). Consequently, the estimated association between 25(OH)D and breast cancer depended on whether baseline (odds ratio [OR]=0.87, 95% confidence interval [CI]: 0.78-0.98 per 10 ng/mL) or second blood draw measures (OR=1.17, 95% CI: 1.08-1.26 per 10 ng/mL) were used.
Concentrations were related to regular (>4 times/week) vitamin D supplement use, which became more common over time. Increases were greater in cases (56% to 84%) than in controls (56% to 77%).
Our results do not explain previously observed differences between retrospective and prospective studies, but do demonstrate how reverse causation and temporal trends in exposure can distort inference.Women worried about breast cancer seem to be taking vitamin D – Jan 2019
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