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Breast Cancer was 4.6 times more likely if have a poor Vitamin D Receptor – Dec 2016

Vitamin D status, receptor gene BsmI (A/G) polymorphism and breast cancer in a group of Egyptian females

Egyptian Journal of Medical Human Genetics, http://dx.doi.org/10.1016/j.ejmhg.2016.11.003
Rasha Rizk Elzeherya, , , Azza A. Baiomya, , Mohamed AbdEl-Fattah Hegazyb, , Rami Faresb, , Abdel-Hady El-Gilanyc, , Refaat Hegazid,

VitaminDWiki

Vitamin D Receptor category has the following

331 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population has a poor VDR (40% of the Obese )

A poor VDR increases the risk of 55 health problems  click here for details
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR


Items in both VitaminDWiki categories Breast Cancer and Vitamin D Receptor are listed here:


See also web

Do genetic polymorphisms of the vitamin D receptor contribute to breast/ovarian cancer?
A systematic review and network meta-analysis - Nov 2018

PDF is available free at Sci-Hub  10.1016/j.gene.2018.07.070


 Download the PDF from VitaminDWiki

Background
Vitamin D is involved in a wide variety of biological processes including bone metabolism, modulation of the immune response, and regulation of cell proliferation and differentiation. The present study aimed to investigate vitamin D status and the genetic polymorphism BsmI (A/G) of vitamin D receptor (VDR) among a group of Egyptian female patients with breast cancer.

Methods
The current study included 60 female patients diagnosed as breast cancer (BC) attending Mansoura Oncology Center, Mansoura University, and 60 age-matched healthy control females. Serum 25(OH) vitamin D level was measured using Enzyme-linked immunosorbent assay (ELISA) kit. A polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) method and fragment analysis were performed to determine the VDR BsmI (A/G) polymorphism.

Results
25(OH) vitamin D levels were significantly lower in the patients with BC (22.1 ± 10.9 ng/ml) compared to controls (41.2 ± 11.22 ng/ml) (p 0.001). Vitamin D deficiency- insufficiency was reported in 76.7% of BC patients and 20% of the controls (P 0.001, OR = 13.1, 95%CI = 5.5 - 31.4).
Bb genotype was statistically higher in the BC patients than in the healthy controls (P 0.001).

  • 81.2% of BC patients were of Bb genotype,
  • 10.9% of BB genotype and
  • 4.3% of bb genotype,

while in controls, 33.3% for each genotype.
No statistically significant difference in allele frequency was observed between the two studied groups.
Carriers of Bb genotype had 4.6 times increased risk of developing breast cancer (95% confidence interval of 2.0–10.3) when compared to other genotypes.

Conclusion
A significant association exists between vitamin D deficiency and the risk of breast cancer. B allele or Bb genotype of VDR may be a susceptibility risk factor for BC development.

Breast Cancer was 4.6 times more likely if have a poor Vitamin D Receptor – Dec 2016        

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