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Many autoimmune diseases associated with low vitamin D or poor Vit D genes – July 2019

Emerging role of vitamin D in autoimmune diseases: An update on evidence and therapeutic implications

Autoimmunity Reviews https://doi.org/10.1016/j.autrev.2019.102350
Giuseppe Murdaca, Alessandro Tonacci, Simone Negrini, Monica Greco, Matteo Borro, Francesco Puppo, Sebastiano Gangemi

 Download the PDF from Sci-Hub VitaminDWiki

Vitamin D plays a key role in in calcium homeostasis and, thus, provides an important support in bone growth by aiding in the mineralization of the collagen matrix. However, vitamin D performs various immunomodulatory, anti-inflammatory, antioxidant and anti-fibrotic actions. Autoimmune diseases result from an aberrant activation of the immune system, whereby the immune response is directed against harmless self-antigens. Does vitamin D play a role in the pathophysiology of autoimmune diseases? And, if so, what is its role? In the last decade, researchers’ interest in vitamin D and its correlations with autoimmune diseases has considerably increased. We conducted a literature review, covering the period January 1, 2009 through March 30, 2019, in PubMed. We analyzed more than 130 studies in order to find a correlation between vitamin D levels and its effect upon several autoimmune diseases. The analysis demonstrated an inverse association between vitamin D and the development of several autoimmune diseases, such as

  • SLE,
  • thyrotoxicosis, (excess of thyroid hormone)
  • type 1 DM,
  • MS,
  • iridocyclitis, (inflammation of the iris)
  • Crohn’s disease,
  • ulcerative colitis,
  • psoriasis vulgaris,
  • seropositive RA,
  • polymyalgia rheumatica. (muscle pain and stiffness, especially in the shoulders)

International multicenter study could allow us to confirm the data already present in the literature in the single clinical studies and to evaluate when to effectively supplement vitamin D in patients who do not take corticosteroids.

Created by admin. Last Modification: Monday August 19, 2019 20:11:15 GMT-0000 by admin. (Version 5)

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12370 Many autoimmune Vit D VDR etc.pdf PDF 2019 admin 20 Jul, 2019 11:47 388.28 Kb 40
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