The Correlation between Vitamin D Levels and the Risk of Postoperative Recurrence in Crohn's Disease
Digestion. 2021 Feb 8;1-9. doi: 10.1159/000513589.
Akihiro Yamada 1 2, Yuga Komaki 1 3, Fukiko Komaki 1 3, Haider Haider 1, Dejan Micic 1, Joel Pekow 1, Sushila Dalal 1, Russell D Cohen 1, Lisa Cannon 1 4, Konstantin Umanskiy 1 4, Radhika Smith 1 4, Benjamin D Shogan 1 4, Roger Hurst 1 4, Neil Hyman 1 4, David T Rubin 1, Atsushi Sakuraba 5
Overview Gut and vitamin D has the following summary
- Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
- Celiac disease has a strong genetic component.
- Most, but not all, people with celiac disease have a gene variant.
- An adequate level vitamin D seems to decrease the probability of getting celiac disease.
- Celiac disease causes poor absorption of nutrients such as vitamin D.
- Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
- The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
- Review in Nov 2013 found that Vitamin D helped
Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
- All items in category gut and vitamin D
Gut category listing contains the following
177 items in GUT category - see also Overview Gut and vitamin D,
- "Ulcerative Colitis" OR UC 839 items Jan 2020
- "celiac disease" OR CD 1830 items July 2019
- IBS or IBD or IRRITABLE BOWEL in title of 37 VitaminDWiki pages as of July 2021
- Gut-Friendly forms of vitamin D
- such as: bio-emulsion, topical, spray, sublingual, inhaled, injection .
27 items along with related searches.
- Crohn's Disease 4X less likely to reoccur after surgery if good level of vitamin D – Feb 2021
- ICU patients greatly helped by Vitamin D loading doses – if gut-friendly – Oct 2020
- 8X more likely to have leaky gut in ICU if low vitamin D - Oct 2019
- Prior to Bariatric Surgery 96 percent were vitamin D deficient – July 2014
- Hospital-Acquired Infections 3X more likely after Gastric Bypass if less than 30 ng vitamin D – Feb 2014
- Vitamin D deficiency after gastrointestinal surgery - 2009
- Crohn's Disease patients normalizing their Vitamin D levels decreased risk of surgery by 44 percent – Aug 2013
- Crohn’s helped by 5000 IU vitamin D – April 2013
- Crohn's Disease relapse rate of 3 in 8 with 1,000 IU vs 0 in 12 with 10,000 IU of Vitamin D – RCT Feb 2017
- Crohn’s disease helped when vitamin D level raised above 30 ng – RCT Feb 2015
- Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor Activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, non-daily Vitamin D dosing, curcumin, intense exercise, etc
Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators
Background and aims: Vitamin D deficiency has been associated with disease activity in Crohn's disease (CD). We assessed whether there is a correlation between vitamin D levels and the risk of postoperative recurrence in CD.
Methods: CD patients who underwent surgery were identified from a prospectively maintained database at the University of Chicago. The primary endpoint was the correlation of serum 25-hydroxy vitamin D levels measured at 6-12 months after surgery and the proportion of patients in endoscopic remission, defined as a simple endoscopic score for CD of 0. Clinical, biological (C-reactive protein), and histologic recurrences were also studied.
Results: Among a total of 89 patients, 17, 46, and 26 patients had vitamin D levels of <15, 15-30, and >30 ng/mL, respectively. Patients with higher vitamin D levels were significantly more likely to be in endoscopic remission compared to those with lower levels (23, 42, and 67% in ascending tertile order; p = 0.028).
On multivariate analysis, vitamin D >30 ng/mL (odds ratio [OR] 0.22, 95% confidence interval pCI 0.07-0.66, p = 0.006) and anti-tumor necrosis factor agent treatment (OR 0.25, 95% CI 0.08-0.83, p = 0.01) were associated with reduced risk of endoscopic recurrence. Rates of clinical, biological, and histologic remission trended to be higher in patients with higher vitamin D levels (p = 0.17, 0.55, 0.062, respectively).
Conclusion: In the present study, higher vitamin D level was associated with lower risk of postoperative endoscopic CD recurrence. Further, studies are warranted to assess the role of vitamin D in postoperative CD recurrence.Crohn's Disease 4X less likely to reoccur after surgery if good level of vitamin D – Feb 2021
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