Association of rs2228570 Polymorphism of Vitamin D Receptor Gene with Lumbar Degenerative Disc Disease.
Turk Neurosurg. 2018 Mar 11. doi: 10.5137/1019-5149.JTN.22275-17.2. [Epub ahead of print]
Özdoğan S1, Yaltirik CK, Yilmaz SG, Koçak A, Isbir T.
Istanbul Training and Research Hospital, Neurosurgery Clinic, Istanbul, Turkey.
Yes, poor backs can be due to genetics and can run in families
- Back Pain category listing has
39 items along with related searches
- Back pain cured with vitamin D – book May 2014
- Back pain extremely associated with low level of vitamin D – May 2014
- Back pain reduced for 95 percent of those who took vitamin D - 2003
- This file resulted in the creation of VitaminDWiki in 2010
Items in both categories Back Pain and Vitamin D Receptor are listed here:
- Spinal disc degeneration 1.8X more likely if poor Vitamin D Receptor – mata-analysis Sept 2020
- Lumbar disc degeneration 30 percent more likely if poor Vitamin D Receptor – May 2019
- Lumbar Degenerative Disc Disease 3X more likely if poor Vitamin D Receptor – March 2018
- Disc Degeneration in women is 1.7X more likely if poor Vitamin D Receptor – meta-analysis Jan 2017
- Degeneration of lumbar disc 2.5 X more likely if poor Vitamin D receptor (not detected by test) Feb 2018
- Lumbar degenerative disc diseases can be prevented via Vitamin D Receptor – many studies
- Spinal disc degeneration is associated with vitamin D receptor genes, and others – March 2013
Vitamin D Receptor category has the following
454 studies in Vitamin D Receptor category
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problemsSee also:
A poor VDR restricts Vitamin D from getting in the cells
43 studies in the Resveratrol category
It appears that 30% of the population have a poor VDR (40% of the Obese )Health problems include: Autoimmune (
Several diseases protect themselves by deactivating the Vitamin D receptor.Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems
17 studies), Breast Cancer ( 19 studies), Colon Cancer ( 12 studies), Cardiovascular ( 22 studies), Cognition ( 16 studies), Diabetes ( 21 studies), Hypertension ( 5 studies), Infant ( 17 studies), Lupus ( 6 studies), Metabolic Syndrome ( 3 studies), Mortality ( 4 studies), Multiple Sclerosis ( 11 studies), Obesity ( 15 studies), Pregnancy ( 22 studies), Rheumatoid Arthritis ( 10 studies), TB ( 8 studies), VIRUS ( 29 studies), Click here for details
Some health problems, such as Breast Cancer and Diabetes, protect themselves by reducing VDR activation
Suspect that SAR-COV-2 also protects itself from Vitamin D
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 44 diseases at least double with poor VDR as of Oct 2019 click here for details
Some health problem, such as Breast Cancer reduce the VDR
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
Compensate for poor VDR by increasing one or more:
Increasing Increases 1) Vitamin D supplement Sun
Vitamin D in the blood
and thus in the cells
2) Magnesium Vitamin D in the blood
AND in the cells
3) Omega-3 Vitamin D in the cells 4) Resveratrol Vitamin D Receptor 5) Intense exercise Vitamin D Receptor 6) Get prescription for VDR activator
Vitamin D Receptor 7) Quercetin (flavonoid) Vitamin D Receptor 8) Zinc is in the VDR Vitamin D Receptor 9) Boron Vitamin D Receptor ?,
10) Essential oils e.g. ginger, curcumin Vitamin D Receptor 11) Progesterone Vitamin D Receptor 12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor 13) Sulfroaphane and perhaps sulfur Vitamin D Receptor 14)Butyrate especially gut Vitamin D Receptor
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Increased risk associated with a poor Vitamin D Receptor
Note: Some diseases reduce VDR activation
those with a * are known to decrease activation
The Vitamin D Receptor only limits the amount of vitamin D getting to a cell, it does not stop it.
If you have a poor vitamin D receptor you need more Vitamin D than others (3X?)
Suspect that applying Vitamin D topically to the back might help - no data
Topical Magnesium (with DMSO) relieves tense muscles in minutes (in back and elsewhere)
Lumbar degenerative disc disease (LDDD) is the most common cause of lower back pain (LBP) and sciatica. The vitamin D receptor (VDR) gene, which is located on chromosome 12 (12q12-q14), was the first gene reported to be potentially related to intervertebral degenerative disc disease risks. We conducted a case-control study of a Turkish population and investigated the association between the VDR gene rs2228570 FokI polymorphism and the development of LDDD.
MATERIAL AND METHODS:
This was a prospective case-control study that included 45 patients with LDDD and 49 healthy individuals (control group). The clinical investigations of the LDDD patients consisted of neurological examinations, lumbar magnetic resonance imaging studies, visual analog scale (VAS) scores, and Oswestry Disability Index scores. The VDR gene rs2228570 FokI polymorphism was analyzed via a real-time polymerase chain reaction.
We found that the individuals with the VDR GG genotype had a significantly increased risk of LDDD, while those with the AG genotype had a significantly decreased risk. In addition, the A allele may have a protective effect against LDDD in the Turkish population. Moreover, the VAS pain results showed that the GG genotype had a significantly higher score than the others.
Our results suggested that the VDR rs2228570 AG genotype was at a decreased risk and the GG genotype was at an increased risk of LDDD in the Turkish population. Since genetic polymorphisms often show ethnic differences, further functional studies are needed to evaluate the genotype and phenotype correlations in large cohorts of various ethnicities.
PMID: 29569696 DOI: 10.5137/1019-5149.JTN.22275-17.2Lumbar Degenerative Disc Disease 3X more likely if poor Vitamin D Receptor – March 2018
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