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Preeclampsia 2X more likely if poor Vitamin D Receptor – April 2019

The possible role of maternal and placental vitamin D receptor polymorphisms and haplotypes in pathogenesis of preeclampsia.

Clin Exp Hypertens. 2019 Apr 20:1-6. doi: 10.1080/10641963.2019.1601203

VitaminDWiki

52 diseases were strongly associated with Vitamin D Receptor as of April 2019
Vitamin D Receptor table shows what compensates for low VDR activation

Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Items in both categories Pregnancy and Vitamin D Receptor are listed here:

Items in both categories Hypertension and Vitamin D Receptor are listed here:

Farajian-Mashhadi F1, Eskandari F2,3, Rezaei M2,3, Eskandari F4, Najafi D5, Teimoori B6,7, Moradi-Sharbabak M6,7, Salimi S2,3.
1 Department of Pharmacology, School of Medicine , Zahedan University of Medical Sciences , Zahedan , Iran.
2 Cellular and Molecular Research Center , Zahedan University of Medical Sciences , Zahedan , Iran.
3 Department of Clinical Biochemistry, School of Medicine , Zahedan University of Medical Sciences , Zahedan , Iran.
4 Institute of Biochemistry and Biophysics , University of Tehran , Tehran , Iran.
5 School of Medicine , Iran University of Medical Sciences , Tehran , Iran.
6 Department of Obstetrics and Gynecology, School of Medicine , Zahedan University of Medical Sciences , Zahedan , Iran.
7 Pregnancy Health Research Center , Zahedan University of Medical Sciences , Zahedan , Iran.

PURPOSE:
Vitamin D deficiency may be a main causative agent in the pathogenesis of preeclampsia (PE). The actions of the active form of vitamin D are mediated via the vitamin D receptor (VDR), which is expressed in numerous organs including placenta. Therefore, we evaluated the potential relationship between maternal and placental VDR polymorphisms and the predisposition to PE in an Iranian population.

METHODS:
This case-control study surveyed 152 PE and 160 normotensive pregnant women. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was performed to examine the maternal and placental VDR Fok1 rs2228570, Bsm1 rs1544410, Taq1 rs731236, and Apa1 rs7975232 polymorphisms.

RESULTS:
The maternal but not placental VDR FokI Ff genotype, was significantly lower in PE women (P = .02 and P = .06, respectively). The maternal and placental VDR FokI polymorphism was associated with lower PE risk in the dominant model (Ff+ff vs. FF) and these genotypes could decrease PE risk (OR, 0.5 [95% CI, 0.3-0.8], P = .007 and OR, 0.5 [95% CI, 0.3-0.9], P = .02, respectively). The haplotype analysis revealed that the maternal and placental TABf haplotype may lead to decreased risk of PE. In addition, the placental TABF haplotype was associated with higher risk of PE. No relationship was observed between PE susceptibility and the maternal and placental VDR Bsm1, Taq1 and Apa1 polymorphisms. There was also no relationship between the maternal and placental VDR polymorphisms and PE severity.

CONCLUSIONS:
the maternal and placental VDR FokI variant was associated with decreased risk of PE in the dominant model.

Created by admin. Last Modification: Tuesday April 23, 2019 13:22:57 GMT-0000 by admin. (Version 2)
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