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Autism may be synergistically treated by Vitamin D and probiotics – July 2022


Vitamin D Status in Children with Autism Spectrum Disorders: Determinants and Effects of the Response to Probiotic Supplementation

Metabolites. 2022 Jul 1;12(7):611. doi: 10.3390/metabo12070611.
Letizia Guiducci 1, Cristina Vassalle 2, Margherita Prosperi 3, Elisa Santocchi 4, Maria Aurora Morales 1, Filippo Muratori 3 5, Sara Calderoni 3 5

A relationship between the presence of clinical symptoms and gastrointestinal (GI) disturbances associated with nutritional deficiencies, including vitamin D (25(OH)D) deficiency, has been observed in autism spectrum disorder (ASD). The aim was to evaluate 25(OH)D levels according to the annual rhythm cycle, gender, the severity of autism, nutritional or clinical status, inflammatory and metabolic biomarkers, GI symptoms, and the clinical response to probiotic/placebo supplementation in preschooler children with ASD. Eighty-one ASD preschoolers (67 males) were assessed with standardized tools for ASD severity (ADOS score) and GI symptoms (by GI-Index at six-items and at nine-items, the latter defined as the Total GI-Index). The 25(OH)D levels were compared among different ASD subgroups according to metabolic and inflammatory biomarkers (leptin, insulin, resistin, PAI-1, MCP-1, TNF-alfa, and IL-6), gender, and the presence or absence of:

  • (i) GI symptoms,
  • (ii) the response to probiotic supplementation (the improvement of GI symptomatology),
  • (iii) the response to probiotic supplementation (improvement of ASD severity).

Only 25% of the ASD children presented an adequate 25(OH)D status (≥30 ng/mL according to the Endocrine Society guidelines). All the 25(OH)D levels falling in the severe deficiency range (<10 ng/mL) were observed in the male subgroup. A significant inverse correlation between 25(OH)D and leptin was observed (R = -0.24, p = 0.037).
An inverse correlation was found between 25(OH)D levels and the GI Index 6-Items and Total GI-Index (R = -0.25, p = 0.026; -0.27, = 0.009) and a direct relationship with the probiotic response (R = 0.4, p = 0.05).
The monitoring of 25(OH)D levels and the co-administration of 25(OH)D and probiotic supplementation could be considered in ASD from early ages.
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Probiotics helps gastrointentional (GI) problems - common in Autistics


VitaminDWiki pages with PROBIOTICS in title (30 as of July 2022)

This list is automatically updated

Items found: 30
Title Modified
Autism may be synergistically treated by Vitamin D and probiotics – July 2022 27 Jul, 2022
COVID Long-Haul fought by probiotics - Jan 2022 29 Jan, 2022
Tested positive for COVID, taking probiotics stopped symptoms 5 days sooner - RCT Jan 2022 18 Jan, 2022
Probiotics augments Vitamin D – review of RCT Dec 2020 22 Jun, 2021
Microbiome improvement by probiotics can be augmented with phages (gut, etc.) 25 Feb, 2021
Vitamin D is aided by probiotics (review of RCTs) – Dec 2020 31 Jan, 2021
New drug application to FDA for a probiotic which might treat COVID-19 – Nov 19, 2020 20 Nov, 2020
Depression treated by Omega-3, Magnesium, Zinc, probiotics, etc - Sept 2017 08 Jan, 2020
Probiotics increased Vitamin D etc in healthy children – RCT Oct 2019 30 Oct, 2019
Schizophrenia reduced by biweekly 50,000 IU Vitamin D and probiotics – RCT Feb 2019 21 Feb, 2019
Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018 12 Jan, 2019
If struggling with mental health you may need Omega-3, Vitamin D. Iron, Probiotics, etc. – US News Sept 2018 11 Sep, 2018
Magnesium, Vitamin D, Omega-3, B12, Probiotics are the first of top 10 supplements for senior men - July 2018 21 Jul, 2018
Antibiotics, probiotics 22 Nov, 2016
Off topic: Consumer Labs has great reviews of supplements– a peek at their probiotics matrix 30 Jul, 2016
Hypothesis: vitamin D and probiotics will reduce type II diabetes – Jan 2013 03 Apr, 2016
Popular supplements 1 Vitamin D, 2 fish oil, 3 CoQ10, 4 multivitamins 5 probiotics - Feb 2016 27 Feb, 2016
Vitamin D receptor functionality improved with probiotics – Sept 2015 02 Sep, 2015
Probiotic and vitamin D synergy - July 2015 11 Jul, 2015
Colon cancer – vitamin D, probiotics, and leptin might help – May 2015 20 May, 2015
Probiotics reduces blood pressure, but not as much as vitamin D does – meta-analysis July 2014 01 Feb, 2015
Probiotic (L. reuteri NCIMB 30242 ) greately increased vitamin D levels for many – RCT July 2013 14 Dec, 2014
Probiotic (L. reuteri NCIMB 30242 ) increased vitamin D levels by 25 percent – RCT July 2013 26 Jul, 2014
Probiotic (Lactobacillus casei Zhang) reduces T2 Diabetes in mice – July 2014 26 Jul, 2014
Probiotics reduced weight gain in mice for many weeks (proof of concept) – June 2014 26 Jul, 2014
Probiotics, prebiotics, and the host microbiome - the science of translation – June 2013 21 Jul, 2014
Probiotic (Lactobacillus reuteri) increased vitamin D levels 22 percent – RCT July 2013 01 Dec, 2013
Probiotics increased vitamin D levels 22 percent in those with excess cholesterol – April 2013 21 May, 2013
Are microbs – probiotics – vitamin D – allergy – asthma – obesity related – Mar 2011 20 Jul, 2011
Many autistic children are getting some Vitamin D, Omega-3, probiotics, etc. - Aug 2019 No value for 'modification_date_major'


Created by admin. Last Modification: Wednesday July 27, 2022 20:36:07 GMT-0000 by admin. (Version 3)

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ID Name Comment Uploaded Size Downloads
18190 Autism probiotics.pdf PDF 2022 admin 27 Jul, 2022 13:54 1.21 Mb 11
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