Table of contents
- VitaminDWiki overview
- Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies - Nov
- Association Between Vitamin D Receptor BsmI, FokI, and Cdx2 Polymorphisms and Osteoporosis Risk: An Updated Meta-Analysis - July
- The association between vitamin D receptor FokI gene polymorphism and osteoporosis in postmenopausal women: a meta-analysis - June
VitaminDWiki overview
Vitamin D Receptor is associated in over 58 autoimmune studies
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators
Items in both categories Osteoporosis and Vitamin D Receptor are listed here:
- Osteoporosis Risk varies with Vitamin D Receptor – three meta-analyses in 2020
- Prevent Osteoporosis and Have Strong Bones - book 2013
- Increased risk of Osteoporosis if poor Vitamin D Receptor (UK males this time) – Sept 2019
- Osteoporosis 3X higher risk of in white men having a poor Vitamin D receptor – Aug 2019
- Osteoporosis is associated with genes such as the Vitamin D Receptor – July 2019
- Osteoporosis 15 percent more likely if poor Vitamin D receptor – meta-analysis Dec 2018
- Disc Degeneration in women is 1.7X more likely if poor Vitamin D Receptor – meta-analysis Jan 2017
- Osteoporosis is associated with more than vitamin D genes – Jan 2016
- 2.8X higher risk of osteoporosis if COPD and modified vitamin D receptor genes – Sept 2015
- Osteoporosis 2.8 X more likely if Vitamin D receptor (VDR) genes altered – Aug 2013
- Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012
Items in both categories Meta-analysis and Vitamin D Receptor are listed here:
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – Meta-Analysis Jan 2021
- Spinal disc degeneration 1.8X more likely if poor Vitamin D Receptor – mata-analysis Sept 2020
- Osteoporosis Risk varies with Vitamin D Receptor – three meta-analyses in 2020
- Multiple Sclerosis 2X-3X more likely if poor Vitamin D Receptor – Meta-analysis Feb 2020
- Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018
- Parkinson’s disease 1.6X more likely if a poor Vitamin D Receptor – meta-analysis Jan 2020
- Risk of Multiple Sclerosis varies with the Vitamin D Receptor – meta-analysis Dec 2019
- Liver Cancer – higher risk if poor genes (Vitamin D receptor etc) – meta-analysis Dec 2019
- Kidney failure 1.1 X more likely if poor Vitamin D Receptor – meta-analysis Dec 2019
- Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis Oct 2019
- Lung Cancer more likely if poor Vitamin D Receptor – meta-analysis June 2019
- Tuberculosis increased risk if poor Vitamin D receptor varies by race – meta-analysis Feb 2019
- Parkinson’s disease 20 percent more likely in Asians if poor Vitamin D Receptor – meta-analysis April 2019
- Osteoporosis 15 percent more likely if poor Vitamin D receptor – meta-analysis Dec 2018
- Psoriasis risk in Caucasians is 1.3 X higher if poor Vitamin D Receptor – meta-analysis Nov 2018
- Vitiligo (spotty skin coloring) is 4 X more likely if poor Vitamin D Receptor – meta-analysis July 2018
- Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017
- Lung Cancer patients were 2.4 times more likely to have a poor Vitamin D Receptor gene – July 2017
- Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017
- Diabetic Retinopathy 2 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2016
- Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016
- Tuberculosis 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Oct 2016
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
- Rheumatoid arthritis is 40 percent more likely if vitamin D Receptor problem – 2 meta-analyses 2015
- Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015
- 2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis Aug 2014
- Multiple Sclerosis and the Vitamin D Receptor – meta-analysis July 2014
- Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014
- Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014
- Tuberculosis, genes and vitamin D – Meta-Analysis Dec 2013
- Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
- Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012
- 10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012
Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies - Nov
Genes & Nutrition volume 15, Article number: 20 (2020)
Jun Long Liao, Qiang Qin, Yong Sheng Zhou, Ru Ping Ma, He Chao Zhou, Mao Rong Gu, Yun Ping Feng, Bo Yuan Wang & Ling Yang
 Download the PDF from VitaminDWiki
Objective
This study aimed to quantitatively summarize the evidence for VDR BsmI gene polymorphism and osteoporosis risk in postmenopausal women.
Materials and methods
The PubMed, EMBASE, Weipu, CNKI, and Wanfang databases were searched for eligible studies. Case-control studies containing available genotype frequencies of B/b were chosen, and odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association.
Results
4485 osteoporosis and 5490 controls were identified in our meta-analysis. In the stratified analysis, a significant association was observed between VDR BsmI gene polymorphism and osteoporosis susceptibility in Caucasians (additive model: OR = 0.809, 95% CI 0.678~0.965, p = 0.019; recessive model: OR = 0.736, 95% CI 0.568~0.955, p = 0.021; and co-dominant model: bb vs. BB OR = 0.701, 95% CI 0.511~0.962 p = 0.028), and we failed to find any significant relationship in Asians.
Conclusion
The present meta-analysis suggests that VDR BsmI genotype is associated with increased risk of postmenopausal osteoporosis in Caucasians but not in Asians. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between VDR BsmI polymorphism and osteoporosis in postmenopausal women.
Association Between Vitamin D Receptor BsmI, FokI, and Cdx2 Polymorphisms and Osteoporosis Risk: An Updated Meta-Analysis - July
Biosci Rep. 2020 Jul 6;BSR20201200. doi: 10.1042/BSR20201200
Bin Chen 1, Wang-Fa Zhu 1, Yi-Yang Mu 1, Biao Liu 1, Hong-Zhuo Li 2, Xiao-Feng He 3
 Download the PDF from VitaminDWiki
Background: Many studies have reported the association between vitamin D receptor (VDR) polymorphism and osteoporosis risk. However, their results were conflicting. Six previous meta-analyses have been published to analyze VDR BsmI, FokI, and Cdx2 polymorphisms on osteoporosis risk. However, they did not evaluate the reliability of statistically significant associations. Furthermore, a lot of new articles have been published on these themes, and therefore an updated meta-analysis was performed to further explore these issues.
Objectives: To explore the association between VDR BsmI, FokI, and Cdx2 polymorphisms polymorphisms and osteoporosis risk.
Methods: The odds ratios (ORs) and 95% confidence intervals (CIs) were pooled to evaluate the association between VDR BsmI, FokI, and Cdx2 polymorphisms and osteoporosis risk. To evaluate the credibility of statistically significant associations, we applied the false-positive report probabilities (FPRP) test and the Venice criteria.
Results: Overall, statistically significantly increased osteoporosis risk was found in Indians and women for VDR FokI polymorphism. Statistically significantly decreased osteoporosis risk was found in West Asians for VDR BsmI polymorphism. However, when we performed an sensitivity analysis after excluding low quality and HWD studies, significantly decreased osteoporosis risk was only found in overall population for VDR BsmI polymorphism.
Further, less-credible positive results were identified when we evaluated the credibility of positive results.</p> Conclusion: These positive findings should be interpreted with caution and indicate that significant association may most likely result from less-credible, rather than from true associations or biological factors on the VDR BsmI and FokI polymorphisms with osteoporosis risk.The association between vitamin D receptor FokI gene polymorphism and osteoporosis in postmenopausal women: a meta-analysis - June
Climacteric https://doi.org/10.1080/13697137.2020.1775806
S. WangORCID Icon,Z. Ai,M. Song,P. Yan,J. Li &S. Wang
Received 30 Aug 2019, Accepted 22 May 2020, Published online: 18 Jun 2020
Objective: This study aimed to quantitatively summarize the evidence for vitamin D receptor (VDR) FokI gene polymorphism and osteoporosis risk in Caucasian and Asian postmenopausal women.
Materials and methods: The PubMed, EMBASE, Weipu, CNKI, and Wanfang databases were searched for eligible studies. Case–control studies containing available genotype frequencies for F/f were chosen, and the odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association.
Results: In total, 3349 osteoporosis cases and 3202 controls were identified in our meta-analysis. In the stratified analysis, a significant association was observed between VDR FokI gene polymorphism and postmenopausal osteoporosis susceptibility in Asian subjects (
- additive model: OR = 1.529, 95% CI 1.053–2.219, p = 0.026;
- dominant model: OR 2.711, 95% CI 1.693–4.342 p < 0.001;
- co-dominant model: ff vs. FF, OR 2.796, 95% CI 1.439–5.433 p = 0.002),
and we failed to find any significant relationship in Caucasian populations.
Conclusion: The present meta-analysis suggests that the VDR FokI genotype is associated with increased risk of osteoporosis in Asian women but not in Caucasian women. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between VDR FokI polymorphism and osteoporosis.
Title change made Nov 2020 caused the visitor count to reset.There have actually been
152 visitors, last modified 25 Nov, 2020, |
ID | Name | Comment | Uploaded | Size | Downloads | |
---|---|---|---|---|---|---|
14609 | Osteo VDR Meta Nov 2020.pdf | PDF 2020 | admin 25 Nov, 2020 18:56 | 1.08 Mb | 19 | |
13999 | Osteoporosis Risk VDR meta.pdf | PDF 2020 | admin 07 Jul, 2020 13:23 | 2.50 Mb | 98 |