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Parkinson’s Disease 3 X more likely if a poor Vitamin D Receptor – May – 2022

Genetic Variability of the Vitamin D Receptor Affects Susceptibility to Parkinson's Disease and Dopaminergic Treatment Adverse Events

Front Aging Neurosci. 2022 Apr 19;14:853277. doi: 10.3389/fnagi.2022.853277
Sara Redenšek 1, Tilen Kristanc 1, Tanja Blagus 1, Maja Trošt 2, Vita Dolžan 1

Vitamin D is a lipid-soluble molecule and an important transcriptional regulator in many tissues and organs, including the brain. Its role has been demonstrated also in Parkinson's disease (PD) pathogenesis. Vitamin D receptor (VDR) is responsible for the initiation of vitamin D signaling cascade. The aim of this study was to assess the associations of VDR genetic variability with PD risk and different PD-related phenotypes. We genotyped 231 well characterized PD patients and 161 healthy blood donors for six VDR single nucleotide polymorphisms, namely rs739837, rs4516035, rs11568820, rs731236, rs2228570, and rs1544410. We observed that VDR rs2228570 is associated with PD risk (p < 0.001). Additionally, we observed associations of specific VDR genotypes with adverse events of dopaminergic treatment. VDR rs1544410 (GG vs. GA + AA: p = 0.005; GG vs. GA: p = 0.009) was associated with the occurrence of visual hallucinations and VDR rs739837 (TT vs. GG: p = 0.036), rs731236 (TT vs. TC + CC: p = 0.011; TT vs. TC: p = 0.028; TT vs. CC: p = 0.035), and rs1544410 (GG vs. GA: p = 0.014) with the occurrence of orthostatic hypotension. We believe that the reported study may support personalized approach to PD treatment, especially in terms of monitoring vitamin D level and vitamin D supplementation in patients with high risk VDR genotypes.
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VitaminDwiki - pages listed in BOTH the categories Parkenson's and Vitamin D Receptor:

VitaminDwiki - Vitamin D Receptor activation can be increased by

any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

Created by admin. Last Modification: Friday May 6, 2022 13:47:53 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
17552 PD VDR.jpg admin 06 May, 2022 16.11 Kb 234
17551 PD VDR.pdf admin 06 May, 2022 279.78 Kb 185