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Lung Cancer risk increases if low Vitamin D, poor activation of Vitamin D Receptor which affects the CALB1 gene – June 2024

Exploring the Role of Vitamin D, Vitamin D-Dependent Proteins, and Vitamin D Receptor Gene Variation in Lung Cancer Risk

Int J Mol Sci. 2024 Jun 17;25(12):6664. doi: 10.3390/ijms25126664.
Tudor Ciocarlie 1, Alexandru Cătălin Motofelea 2, Nadica Motofelea 3, Alina Gabriela Dutu 4, Alexandra Crăciun 4, Dan Costachescu 5, Ciprian Ioan Roi 6, Ciprian Nicolae Silaghi 4, Andreea Crintea 4


VDR actions

VDR controls the CALB1 gene ==> calbindin 1, 2,3 (calcium)
Lung cancer has an unfavorable prognosis with a rate of low overall survival, caused by the difficulty of diagnosis in the early stages and resistance to therapy. In recent years, there have been new therapies that use specific molecular targets and are effective in increasing the survival chances of advanced cancer. Therefore, it is necessary to find more specific biomarkers that can identify early changes in carcinogenesis and allow the earliest possible treatment. Vitamin D (VD) plays an important role in immunity and carcinogenesis. Furthermore, the vitamin D receptor (VDR) regulates the expression of various genes involved in the physiological functions of the human organism. The genes encoding the VDR are extremely polymorphic and vary greatly between human populations. To date, there are significant associations between VDR polymorphism and several types of cancer, but the data on the involvement of VDR polymorphism in lung cancer are still conflicting. Therefore, in this review, our aim was to investigate the relationship between VDR single-nucleotide polymorphisms in humans and the degree of risk for developing lung cancer. The studies showcased different gene polymorphisms to be associated with an increased risk of lung cancer: TaqI, ApaI, BsmI, FokI, and Cdx2. In addition, there is a strong positive correlation between VD deficiency and lung cancer development. Still, due to a lack of awareness, the assessment of VD status and VDR polymorphism is rarely considered for the prediction of lung cancer evolution and their clinical applicability, despite the fact that studies have shown the highest risk for lung cancer given by TaqI gene polymorphisms and that VDR polymorphisms are associated with more aggressive cancer evolution.
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VitaminDWiki - Overview Lung cancer and vitamin D

Table of Contents as of June 2024
VitaminDWiki - 7 Lung Cancer and Meta-analysis
VitaminDWiki - 5 studies in both categories Lung Cancer and Vitamin D Receptor
   Lung Cancer: Role of Vitamin D, Vitamin D-Dependent Proteins, and Vitamin D Receptor - June 2024
   Has Lung Cancer, like many other cancers,COVID, etc. learned how to protect itself from Vitamin D by altering the VDR?
Cost of CT scans and Vitamin D for a 20% reduction in lung cancer deaths
Estimation of the cost of CT scan per pack
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Lung Cancer factoids from The Body by Bill Bryson, 2019
Why is the number of lung cancers in people who have never smoked increasing?

VitaminDWiki - Lung Cancer more likely if poor Vitamin D Receptor – meta-analysis June 2019

VitaminDWiki - Lung Cancer is up to 7 X more deadly if poor vitamin D genes – Oct 2021

Attached files

ID Name Comment Uploaded Size Downloads
21381 CALB1 gene affected by VDR.webp admin 29 Jun, 2024 18.70 Kb 20
21380 VDR Regulates.webp admin 29 Jun, 2024 45.04 Kb 24
21379 VDR Lung Cancer.webp admin 29 Jun, 2024 59.93 Kb 31
21378 D, VDR and Lung Cancer_CompressPdf.pdf admin 29 Jun, 2024 207.77 Kb 12