Poor response to Asthma inhaler if poor Vitamin D Receptor – Dec 2019

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Influence of vitamin D receptor gene FokI and ApaI polymorphisms on glucocorticoid response in patients with asthma

International Forum of Allergy & Rhinology, . 2019;00:1-8.
Nesrine A. Mohamed, PhD1 and Asmaa S. Abdel-Rehim, PhD2

 Download the PDF from Sci-Hub via VitaminDWiki

Background: Glucocorticoid (GC)-resistant asthma, a complex disease phenotype, has a high morbidity and mortality and takes up a disproportionate share of healthcare costs. The aim of this work was to assess serum 25-hydroxyvitamin D (25(OH)VD) levels in steroid-resistant, steroid-sensitive patients with asthma and in healthy controls, and to investigate the association between the vitamin D receptor gene (VDR) FokI and Apal polymorphisms and GC resistance in patients with asthma.

Methods: This case-control study included 70 patients with severe bronchial asthma and 30 apparently healthy controls. Atopic status was determined by skin-prick test reaction to the most common locally-encountered allergens. A GC reversibility test was performed to differentiate between GC-sensitive and GC-resistant asthma. For all subjects, analysis of the VDR FokI and Apal polymorphisms by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and measurement of serum 25(OH)VD levels by enzyme-linked immunosorbent assay (ELISA) were performed.

Results: The frequencies of FokI polymorphism genotypes and alleles differed significantly between patients with asthma and controls. The frequencies of the TT genotype and T allele carriers were significantly higher among patients with asthma than among controls, and also among GC-resistant patients with asthma than among GC-sensitive patients with asthma. Additionally, serum 25(OH)VD levels differed significantly among the 3 VDR FokI polymorphic genotypes in GC-resistant patients with asthma; the highest level was detected in the TT genotype. No significant differences in Apal were found.

Conclusion: We found a possible association between the Fokl T allele and GC resistance in patients with asthma. Variations in VDR Fokl might also play a role in 25(OH)VD levels. © 2019 ARS-AAOA, LLC.

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Breathing category starts with the following

428 items in Breathing category

Breathing-related Overviews at VitaminDWiki:
Allergy   Lung Cancer   TB   Asthma  Influenza  Colds and flu
Pneumonia   Respiratory infections   COPD   Air Polution   Smoking   Cystic Fibrosis

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Overview Asthma and Vitamin D contains

• VitaminDWiki pages containing ASTHMA in title (137 as of July 2022)
• Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014
  • Started with 100,000 IU loading dose and has standard-of-care Asthma drug
• Asthma may be treated by Vitamin D if more than 40 ng for 12 months – Sept 2018
• Those with Asthma or COPD had half the response to Vitamin D – March 2020
  • Those with Asthma need larger doses to get the same response.
  • perhaps need gut-friendly Vitamin D
• Asthma occurrence rate reduced 3X by Vitamin D – 8 study meta-analysis - Aug 2021
• Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
• Adult-onset asthma 2X more likely if low vitamin D and not hyperallergenic – May 2018
• Children had poor lung function if mothers had low vitamin D while pregnant – Nov 2022
• 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
  • CDC list of high-risk for COVID-19 includes Asthma
• Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018
• Asthmatic children taking Corticosteroids had 2X more vitamin D intake, but lower levels – July 2017
• Traffic pollution increases asthma unless supplement with Vitamin D (mice) June 2018
• Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
• Proof that Vitamin D Works 92 health problems prevented/treated as of Nov 2020
  • Asthma has been proven to be treated by Vitamin D in at least 4 random controlled trials
• Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016
• Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019
• Women with asthma 35X more likely to be vitamin D deficient – Oct 2013
• If high vitamin D during pregnancy the child is 5X less likely to get asthma
• Asthma is treated by Vitamin D – now they are trying to understand why – Feb 2015
• Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015
• Why deficiencies in vitamin D and magnesium are linked to asthma Magnesium allows muscles to relax
• Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
• The worse the bronchial asthma, the lower the vitamin D – Jan 2017 has the following chart

click on chart to see the study

Overview Asthma and Vitamin D contains

This list is automatically updated

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The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor Activation can be increased by any of: Resveratrol,  Omega-3,  Magnesium, Zinc.  Quercetin,  non-daily Vit D.  Curcumin, intense exercise,  Ginger,  Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

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The lungs can activate vitamin D locally – a Vitamin D inhaler may help lungs – Aug 2016
Has helped several people with Asthma as of Dec 2019

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VitaminDWiki - Vitamin D Receptor pages with "ASTHMA" in title

This list is automatically updated
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• 20 ng of vitamin D is enough for African American PTH – Dec 2011
• 20 percent change in vitamin D levels of critically ill during a 24 hour period – Oct 2011
• 20 percent fewer male hip fractures if more Magnesium in the water – July 2013
• 20 percent less chance of Parkinson’s disease if work outdoors some – Thesis Feb 2013
• 20 percent less Rheumatoid Arthritis if got lots of sunshine – Feb 2013
• 20 percent of Critically ill in India had undetectable vitamin D, and 62 percent died – Jan 2013
• 20 ways to increase Vitamin D
• 20 X more Parkinson's and 100X more Autism with GMO soy in China
• 20 year review concludes that Vitamin D reduce ageing – July 2010
• 20,000 COVID-19 infections at Amazon (far less than US average of 34,000) – Oct 1, 2020
• 20,000 IU of Vitamin D weekly gave many benefits – RCT Aug 2019
• 20,000 IU weekly did not get 43 percent of Scottish Cancer patients to a level of 30 ng of vitamin D – April 2014
• 200 IU needed to increase vitamin D levels by 1 ng (not 100 IU) – summary of 25 studies – Feb 2014
• 200 IU of Vitamin D does not prevent pre-eclampsia – RCT Aug 2012
• 200 IU of vitamin D during pregnancy did not help (no surprise) - May 2015
• 200 IU of vitamin D while pregnant raised levels by a paltry 2 ng – RCT April 2019
• 200 IU per 100 gram of egg yoke when add vitamin D to poultry feed in Europe – Aug 2011
• 200 IU vitamin D daily not enough to change infant mortality – May 2011
• 200 IU vitamin D per kg is not enough for some health problems (example– bone marrow stem cell) – July 2016
• 200 to 2000 IU vitamin D daily did not improve child bone density – BMJ Jan 2011
• 200 to 500 IU vitamin D does not benefit bones nor prostate cancer – July 2012
• 200,000 IU restored levels in HIV children having low vitamin D - Nov 2014
• 2000 IU daily dose of vitamin D would save Germany 37 billion euros – Aug 2010
• 2000 IU daily raised vitamin D levels by 5 nanograms while on submarine patrol – July 2014
• 2000 IU of vitamin D - too much or to little
• 2000 IU of vitamin D during pregnancy got most infants to more than 12 ng (need more) – RCT Aug 2015
• 2000 IU of vitamin D for just 2 weeks helped in many ways – RCT June 2016
• 2000 IU of vitamin D for just 5 days did not treat severe pneumonia – RCT June 2012
• 2000 IU of vitamin D helped Type 2 diabetic women, but was not enough – July 2012
• 2000 IU of vitamin D is a step in the right direction for Canada– Nov 2010
• 2000 IU of vitamin D reduced fatigue of advanced cancer – RCT May 2012
• 2000 IU of vitamin D should improve health in winter – RCT almost completed Feb 2014
• 2000 IU of vitamin D should improve toddlers health in winter – RCT almost completed Feb 2014
• 2000 IU of vitamin D- doctors trained that it was too much, but it is often too little
• 2000 IU raised black teens vitamin D level to 34 ng and they lost fat – Oct 2010
• 2000 IU raised vitamin D levels of thin teens by 10 ng, obese teens by 6 ng – Oct 2012
• 2000 IU vitamin D during pregnancy and 800 IU to infant resulted in less use of antibiotics – RCT April 2014
• 2000 IU vitamin D not enough to get most Chinese to 20 ng level – RCT Feb 2015
• 2000 IU vitamin D raised virtually all Lebanese youths above 20 ng – RCT Oct 2013
• 2000 IU vitamin D was safe and helped elderly – Feb 2011
• 2000 IU vitamin D3 was not enough for children with chronic kidney disease – Feb 2013
• 2000 to 3000 IU required to start to help with osteoporos – June 2010
• 20000 IU vitamin D and MS – less fatigue and relapse Dec 2010
• 200000 IU vitamin D daily can result in Hypervitaminosis in weeks – 1992
• 2010 recommendations for Vitamin D are Deficient – by 1997 panelists
• 2017 Flu in Australia was bad and 79,000 died in US, 2019 Flu in Australia was worse (get flu shot AND Vitamin D)
• 2017 Vaccine may prevent only 10 percent of influenza, Vitamin D prevents 70 percent
• 21 fewer days in hospital with ARDS (COVID) if 10,000 IU of Vitamin D daily after enter hospital – RCT April, 2022
• 21st Workshop on Vitamin D - Spain May 2018
• 22 percent more bone cracking found with low vitamin D – July 2013

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