Influence of vitamin D receptor gene FokI and ApaI polymorphisms on glucocorticoid response in patients with asthma
International Forum of Allergy & Rhinology, . 2019;00:1-8.
Nesrine A. Mohamed, PhD1 and Asmaa S. Abdel-Rehim, PhD2
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Overview Asthma and Vitamin D contains
- Asthma may be treated by Vitamin D if more than 40 ng for 12 months – Sept 2018
- Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
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- Asthmatic children taking Corticosteroids had 2X more vitamin D intake, but lower levels – July 2017
- Vitamin D supplements could halve risk of serious asthma attacks – Cochrane conclusion – Sept 2016
- Traffic pollution increases asthma unless supplement with Vitamin D (mice) June 2018
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
- Proof that Vitamin D Works 92 health problems prevented/treated as of Nov 2020
- Asthma has been proven to be treated by Vitamin D in at least 4 random controlled trials
- Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016
- Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019
- Women with asthma 35X more likely to be vitamin D deficient – Oct 2013
- If high vitamin D during pregnancy the child is 5X less likely to get asthma
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- Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015
- Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014 intervention
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397 items includes Asthma, Pneunomia, RTI, TB, Allergy, COPD - All items in category Autoimmune and Vitamin D
177 items Meta-Analyses in VitaminDWiki
- Asthmatics less able to breathe if low vitamin D – meta-analysis Nov 2019
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Overview Asthma and Vitamin D contains
Asthma worse if poor Vitamin D Receptor (not get to cells):
- Poor response to Asthma inhaler if poor Vitamin D Receptor – Dec 2019
- Asthma 3.7X higher risk of poor Vitamin D Receptor (teens in Taiwan in this case) – Nov 2019
- Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis Oct 2019
- Asthmatic children 5X more likely to have a poor Vitamin D Receptor – June 2019
- Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016
- 2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015
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The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor Activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc. Quercetin, non-daily Vit D. Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators
The lungs can activate vitamin D locally – a Vitamin D inhaler may help lungs – Aug 2016
Has helped several people with Asthma as of Dec 2019Download the PDF from Sci-Hub via VitaminDWiki
Background: Glucocorticoid (GC)-resistant asthma, a complex disease phenotype, has a high morbidity and mortality and takes up a disproportionate share of healthcare costs. The aim of this work was to assess serum 25-hydroxyvitamin D (25(OH)VD) levels in steroid-resistant, steroid-sensitive patients with asthma and in healthy controls, and to investigate the association between the vitamin D receptor gene (VDR) FokI and Apal polymorphisms and GC resistance in patients with asthma.
Methods: This case-control study included 70 patients with severe bronchial asthma and 30 apparently healthy controls. Atopic status was determined by skin-prick test reaction to the most common locally-encountered allergens. A GC reversibility test was performed to differentiate between GC-sensitive and GC-resistant asthma. For all subjects, analysis of the VDR FokI and Apal polymorphisms by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and measurement of serum 25(OH)VD levels by enzyme-linked immunosorbent assay (ELISA) were performed.
Results: The frequencies of FokI polymorphism genotypes and alleles differed significantly between patients with asthma and controls. The frequencies of the TT genotype and T allele carriers were significantly higher among patients with asthma than among controls, and also among GC-resistant patients with asthma than among GC-sensitive patients with asthma. Additionally, serum 25(OH)VD levels differed significantly among the 3 VDR FokI polymorphic genotypes in GC-resistant patients with asthma; the highest level was detected in the TT genotype. No significant differences in Apal were found.
Conclusion: We found a possible association between the Fokl T allele and GC resistance in patients with asthma. Variations in VDR Fokl might also play a role in 25(OH)VD levels. © 2019 ARS-AAOA, LLC.
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