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Vitamin D Receptor in vitiligo skin activated by UVB – May 2018

Narrow-band UVB effects on cutaneous vitamin D receptor expression and serum 25-hydroxyvitamin D in generalized vitiligo.

Photodermatol Photoimmunol Photomed. 2018 May;34(3):175-183. doi: 10.1111/phpp.12362. Epub 2017 Nov 24.
El-Hanbuli HM1, Dawoud NM2, Mahmoud RH3.
1 Department of Pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
2 Department of Dermatology, Andrology and STDs, Menoufia University, Shebin Elkoom, Egypt.
3 Department of Biochemistry and molecular biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

VitaminDWiki

Vitamin D Receptor page has the following

Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation.
You might feel the benefit within days of adding one or more of the above


BACKGROUND/PURPOSE:
Vitamin D has a role in variety of autoimmune diseases including vitiligo. Narrow-band UVB (NB-UVB) treatment of vitiligo might act through its effects on vitamin D and its receptor.This study is the first to elucidate NB-UVB effects on immunohistochemical vitamin D receptor (VDR) expression in generalized vitiligo and correlate it with serum vitamin D and repigmentation response.

METHODS:
Using immunohistochemistry, VDR expression was estimated in skin biopsies of 30 controls and 30 vitiligo patients; from vitiligo lesion, perilesional skin at baseline and from repigmented and nonresponding skin after 24 NB-UVB sessions. Baseline serum 25-hydroxyvitamin D 25(OH)D was investigated and repeated after 24 NB-UVB sessions.

RESULTS:
Vitamin D receptor expression and serum 25(OH)D in controls were significantly higher compared to vitiligo patients. After NB-UVB therapy, there was a significant rise in VDR expression and serum 25(OH)D. VDR expression was significantly higher in repigmented skin compared to nonresponding lesion. Improvement in the clinical outcome score was associated with higher baseline VDR expression and higher serum 25(OH)D.

CONCLUSIONS:
NB-UVB phototherapy is associated with improved cutaneous VDR expression and vitamin D synthesis. Better repigmentation response to NB-UVB may be related to higher baseline VDR expression and its upregulation after phototherapy.

Created by admin. Last Modification: Sunday November 11, 2018 18:59:30 GMT-0000 by admin. (Version 1)
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