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CBD may be synergistic with Vitamin D (improves VDR in rats) - Aug 2022

Cannabidiol improves thyroid function via modulating vitamin D 3 receptor in vitamin D 3 deficiency diet-induced rat model

J Food Sci Technol . 2022 Aug;59(8):3237-3244.
doi: 10.1007/s13197-022-05492-3   PDF is behind paywall for a year
Mahendra Kumar Trivedi 1, Sambhu Mondal 2, Snehasis Jana 2

The study was evaluated the impact of cannabidiol (CBD) on thyroid hormones by modulation cannabinoid receptor-2 (CB2) and vitamin D receptor (VDR) in rats fed with vitamin D3 deficiency diet (VDD). CB2-receptors were analyzed by RT-PCR method and others biomarkers by ELISA.

  • The relative expression of CB2 (thyroid ~ 4 folds),
  • VDR protein (liver, 151.72%))), and
  • (kidney, 66%) was significantly increased in CBD-60 compared to VDD.

Vitamin D3 metabolites were significantly increased

  • serum (189.42%),
  • kidney (73.84%), and
  • liver (58.11%) in CBD-60 than VDD.

Increased thyroxine (59.9%) and calcitonin (213.59%); while decreased thyroid-stimulating hormone (36.15%) and parathyroid hormone (38.64%) was observed CBD treatment in VDD rats.
In conclusion, CBD treatment improves CB2 and VDR expression and the level of vitamin D3 metabolites, along with improved thyroid hormones, including calcitonin. This is the first report with an improved CB2 and VDR expression after CBD treatment in VDD induced animals. Thus, CBD can be considered to use in hypothyroidism conditions and to maintain bone health.

Google Scholar: CBD “Vitamin D” 3,450 hits as of July 2022

Google Scholar

  • Effects of Cannabidiol Interactions with CYP2R1, CYP27B1, CYP24A1, and Vitamin D3 Receptors on Spatial Memory, Pain, Inflammation, and Aging in Vitamin D3 Deficiency Diet-Induced Rats – April 2022 https://doi.org/10.1089/can.2021.0240 VDR increased by 50% same author as the study on this page $51 PDF
  • CBD for Dementia they sell CBD, no mention of Vitamin D
    • They also have CBD pages for Migraines, Psoriasis, PTSD, Sciatica, IBS. Acne. Back Pain, High Blood Pressure, Sleep, Schizophrenia, Allergies, Gout, MS, Shingles, Menstrual Cramps, Autism, etc. etc,
    • A poor VDR is associated with the risk of 55 health problems
    • The risk of 44 diseases at least double with poor (Vitamin D Receptor|VDR)) as of Oct 2019

Founder of VitaminDWiki researched CBD and Vitamin D in 2017: the combination looked very promising

Looked at >100 items on the web at the time
Have been taking a dropper full of CBD about 3 times per week since then
Expect RCTs to find that CBD improved vitamin D/VDR in humans sometime in the 2020's
The Vitamin D Receptor has been around for ~400 million years
endocannabinoid system has been around for 800 million years

The Many Medicinal Benefits of Cannabis and Cannabidiol (CBD) - Mercola Aug 2022

As of 2022, 19 states have legalized cannabis for adult use and the 2018 Farm Bill legalized industrial hemp as a crop
As patients and the medical community embrace cannabis and CBD for pain relief, harm and even deaths from opioids will diminish
The existence of cannabinoid receptors in humans and other mammals, called the endocannabinoid system, gives clues to why cannabis and CBD affect so many body systems positively
Many industries, from Big Pharma to the alcohol, lumber, gas and oil and clothing industries, could lose profits from a booming cannabis industry

Health problems helped by CBD
  • Allergic asthma — "CBD treatment decreased the inflammatory and remodeling processes in the model of allergic asthma," according to the European Journal of Pharmacology9
  • Anxiety and sleep — "Cannabidiol may hold benefit for anxiety-related disorders," The Permanente Journal10
  • Autism spectrum disorders (ASD) — "Cannabis in ASD patients appears to be a well tolerated, safe and effective option to relieve symptoms associated with ASD," Scientific Reports11
  • Blood pressure — "This data shows that acute administration of CBD reduces resting BP and the BP increase to stress in humans," JCI Insight12
  • Cancer pain, nausea and lack of appetite — "The National Cancer Institute currently recognizes medicinal C. sativa as an effective treatment for providing relief in a number of symptoms associated with cancer, including pain, loss of appetite, nausea and vomiting, and anxiety," BioMed Research International13
  • Cancer/tumors — "Cannabidiol (CBD), one of the compounds present in the marijuana plant, has antitumor properties," Cancer Letters14
  • Diabetes — "These results suggest that the neuroprotective effects of CBD in middle-aged diabetic rats ... are related to a reduction in neuroinflammation," Neurotoxicity Research15
  • Epilepsy — "CBD is a well-tolerated and effective antiseizure agent and illustrates a potential disease-modifying effect of CBD on reducing both seizure burden and associated comorbidities well after the onset of symptomatic seizures," Epilepsia16
  • Inflammation — "CBD that exerts prolonged immunosuppression ... might be used in chronic inflammation, the terpenoids ... might thus be used to relieve acute inflammation," Cannabis and Cannabinoid Research17
  • Irritable bowel diseases — "Clinical trials suggest that there may be a therapeutic role for cannabinoid therapy in the treatment of IBD," Current Gastroenterology Reports18
  • Multiple Sclerosis — "As cannabis legalization has impacted the variety of cannabis products available, there appears to be growing numbers ... using cannabis ... reporting use of highly efficacious products with minimal side-effects," Multiple Sclerosis and Related Disorders19
  • Neurodegenerative and cardiovascular diseases — "CBD has been found to possess antioxidant activity in many studies, thus suggesting a possible role in the prevention of both neurodegenerative and cardiovascular diseases," BioMed Research International20
  • Ovarian function/female reproductive system — Impacts "the female reproductive system where it affects folliculogenesis, oocyte maturation and ovarian endocrine secretion," Journal of Ovarian Research21
  • PTSD and nightmares — "Administration of oral CBD in addition to routine psychiatric care was associated with PTSD symptom reduction ... CBD also appeared to offer relief in a subset of patients who reported frequent nightmares as a symptom of their PTSD," Journal of Alternative and Complementary Medicine22
  • Pain, migraine, detoxification from opioids — "There is accumulating evidence for various therapeutic benefits of cannabis/cannabinoids, especially in the treatment of pain, which may also apply to the treatment of migraine and headache. There is also supporting evidence that cannabis may assist in opioid detoxification and weaning, thus making it a potential weapon in battling the opioid epidemic," Headache23
  • Parkinson's and Alzheimer's diseases — "CBD may be effective in the treatment of five syndromes, currently labeled recalcitrant to therapeutic success, and wherein improved pharmacological intervention is required: intractable epilepsy, brain tumors, Parkinson's disease (PD), Alzheimer's disease (AD) and traumatic brain injury," Frontiers in Integrative Neuroscience24
  • Pediatric seizures — "The efficacy and safety profile of CBDV suggest it may have therapeutic value for early life seizures," Neuropharmacology25


VitaminDWiki pages with CBD in title (7 as of Aug 2022)

This list is automatically updated

Items found: 7

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