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Temporary hair loss (Telogen Effluvium) is 15X more likely if poor Vitamin D Receptor – Oct 2019

Vitamin D Receptor Gene Polymorphism In Chronic Telogen Effluvium; A Case-Control Study

Clinical, Cosmetic and Investigational Dermatology October 2019 Volume 2019:12 Pages 745—750. DOI https://doi.org/10.2147/CCID.S227232

VitaminDWiki

Items in both categories Autoimmune and Vitamin D Receptor are listed here:


Vitamin D Receptor table has many low cost ways to activate the VDR

Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells
13) Sulfroaphone and perhaps sulfurVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

 Download the PDF from VitaminDWiki
Image
Iman Seleit,1 Ola A Bakry,1 Eman Badr,2 Eman H Hassan1

  • 1Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University, Menoufiya Governorate, Egypt;
  • 2 Department of Medical Biochemistry, Faculty of Medicine, Menoufiya University, Menoufiya Governorate, Egypt
  • Correspondence: Ola A Bakry: Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University, Shibeen El Koom, Menoufiya Governorate 32817, Egypt, Tel +201065190509, Email olabakry8 at gmail.com


Background: Telogen effluvium (TE) is a form of alopecia characterized by diffuse hair shedding. Vitamin D receptor (VDR) plays a role in hair cycle regulation as it is expressed in follicular keratinocytes and dermal papilla cells.

Purpose: To investigate the association between Cdx1 and Taq1 VDR gene polymorphisms and chronic TE.

Methods: Thirty female patients with chronic TE were selected and 30 healthy, age- and sex-matched volunteers were included as a control group. Detection of VDR gene polymorphisms Taq1 and Cdx1 was done by real-time polymerase chain reaction.

Results: Regarding Taq 1, CC genotype was present in 30% of cases versus 3.3% of controls. TC genotype was present in 33.3% of cases and 36.7% of controls. CC genotype was significantly associated with cases (P=0.01). It increases the risk of chronic TE by 14.7 folds. C allele was significantly associated with patient group (P=0.004).
It increases the risk of disease occurrence by 3.1 folds. Regarding Cdx1, AA genotype was present in 6.7% of cases versus 3.3% of controls. GA genotype was present in approximately 30% of cases and 6.7% of controls. GA genotype was significantly associated with cases (P=0.03). It increases the risk of chronic TE by 6.3 folds. A allele was significantly associated with patient group (P=0.007). It increases the risk of disease occurrence by 3.8 folds.

Limitations: The main limitation is the small number of cases due to the time and financial constraints. Only chronic TE was analyzed, therefore, other types should be investigated in the following studies.

Conclusion: After exposure to primary physical or mental stressor, hair follicles are stimulated to enter prematurely into telogen and shed out. In individuals with Taq1 and Cdx1 polymorphisms, the disease persists as a result of prevention of new anagen growth and inhibition of hair follicle stem cell proliferation.

From the web

  • “Telogen effluvium is a form of temporary hair loss that usually happens after stress, a shock, or a traumatic event. It usually occurs on the top of the scalp”
  • “Telogen effluvium (TE) is probably the second most common form of hair loss dermatologists see”

Created by admin. Last Modification: Wednesday October 23, 2019 00:06:14 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
12836 VDR hair loss.jpg admin 22 Oct, 2019 23:52 93.96 Kb 184
12835 VDR hair loss.pdf admin 22 Oct, 2019 23:51 292.88 Kb 81
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