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Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015

[An analysis of vitamin D receptor gene polymorphisms and serum 25-hydroxyvitamin D levels in patients with Crohn's disease]

[Article in Chinese]
Zhonghua Nei Ke Za Zhi. 2015 Jul;54(7):601-6.
Xia S, Lin X, Guo M, Jiang L, Jin J, Lin X, Ding R, Li S, Jiang Y1.

See also VitaminDWiki

The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor Activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, non-daily Vitamin D dosing, curcumin, intense exercise, etc
   Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators


Note: Crohn's is 2.7X more associated with poor Receptor than low Vitamin D in the blood
     (Odds Ratio = 7.580 vs 2.842)

Breast Cancer has learned how to deactivate the Vitamin D Receptor
Wonder if Crohn's Disease has learned the same trick?


OBJECTIVE: To investigate the association of Crohn's disease (CD) with vitamin D receptor (VDR) gene polymorphisms and serum 25-hydroxyvitamin D [25(OH)D] level.

METHODS: A total of 297 CD patients and 446 healthy controls were enrolled in our study. Four single nucleosides of VDR (Fok I, Bsm I, Apa I and Taq I) were genotyped by SNaPshot. Serum 25(OH)D levels were tested by electro-chemiluminescence immunoassay in 124 CD patients and 188 matched random controls.

RESULTS:
By Chi-square test and Bonferroni correction, the frequencies of mutant allele (A) and mutant genotype (GA+AA) of Bsm I were significantly decreased in CD patients compared to controls [3.70%(22/594) vs 7.51%(67/892), 95% CI 0.289-0.776, P=0.002; 7.41%(22/297) vs 14.80%(66/446), 95% CI 0.277-0.765, P=0.002, respectively]. The similar results were seen for the mutant allele (C) and mutant genotype (TC+CC) of Taq I [4.21%(25/594) vs 7.62%(68/892), 95% CI 0.333-0.852, P=0.008; 8.42%(25/297) vs 14.57% (65/446), 95% CI 0.331-0.877, P=0.012]. The analyses of linkage disequilibrium (LD) and haplotype were performed by Haploview 4.2 and R software, respectively. The Bsm I, Apa I and Taq I polymorphic loci were found to be in a strong LD, and the AAC haplotype was significantly reduced in CD patients compared to controls [3.14% vs 6.46%, 95% CI 0.273-0.815, P=0.004].
The further serological analysis showed that average serum 25(OH)D level in CD patients was significantly lower than that of controls [(15.46±8.11) µg/L vs (21.64±9.45) µg/L, P<0.001].
By linear regression analysis, serum 25(OH)D levels in CD patients were negatively correlated to Crohn's disease activity index (β=-0.829, P<0.001), platelet count (β=-0.253, P<0.001) and the ratio of neutrophils (β=-0.136, P=0.005) independently, whereas positively related to erythrocyte sedimentation rate (β=0.191, P=0.001).
Furthermore, logistic regression analysis was applied for establishing the models of gene-environment interaction. In result, both the mutant genotype (CA+AA) of Apa I and vitamin D deficiency (<20 µg/L) were shown to be the independent risk factors for CD (OR = 7.580, 95% CI 2.983-19.261, P<0.001; OR=2.842, 95% CI 1.300-6.211, P=0.009, respectively). Besides, vitamin D deficiency in CD patients had multiplicative interactions with the mutant genotype (TC+CC) of Fok I, genotype (CA+AA) of Apa I and genotype (TC+CC) of Taq I, respectively (OR=0.419, 95% CI 0.194-0.906, P=0.027; OR=0.309, 95% CI 0.111-0.855, P=0.024; OR=5.841, 95% CI 1.082-31.538, P=0.040; respectively).

CONCLUSIONS:
VDR (Bsm I, Apa I and Taq I) polymorphisms and serum 25(OH)D levels are significantly related to CD. Both the mutant genotype (CA+AA) of Apa I and vitamin D deficiency are independent risk factors of CD. The mutations of VDR (Fok I, Apa I and Taq I) and vitamin D deficiency might have a synergistic effect on CD susceptibility.

PMID: 26359022

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Created by admin. Last Modification: Wednesday November 13, 2019 19:17:40 GMT-0000 by admin. (Version 17)

Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015        

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