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Colorectal Cancer Patients 2.4 X more likely to have poor Vitamin D receptors (less D to cells) – April 2020

Decreased Vitamin D Receptor Protein Expression Is Associated With Progression and Poor Prognosis of Colorectal Cancer Patients

Int J Clin Exp Pathol, 2020 Apr 1;13(4):746-755. eCollection 2020. PMID: 32355523
Qi Shi 1, Xue-Ping Han 1, Jie Yu 2, Hao Peng 1, Yun-Zhao Chen 2, Feng Li 1 3, Xiao-Bin Cui 1

VitaminDWiki

Note: to believe that a measurement is not ddue to chance it must have a P <0.05
This measurement has a P = 0.0000000000000000005

Note: Several Cancers have "learned" how to protect themselves from Vitamin D
After the cancer starts, it decreases the Vitamin D Receptor activation.
   Thus for some cancers: Cancer ==> poor VDR, rather than poor VDR ==> Cancer


Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc
Note: The founder of VitaminDWiki, who has a poor VDR, uses 10 of the 12 known VDR activators


Vitamin D Receptor and Cancers

Items in both categories Vitamin D Receptor and Cancer - Breast:

Items in both categories Vitamin D Receptor and Cancer - Colon:

Items in both categories Vitamin D Receptor and Cancer

Items in both categories Vitamin D Receptor and Cancer - other:

Items in both categories Vitamin D Receptor and Cancer - Skin:

Items in both categories Vitamin D Receptor and Cancer - Prostate:

Items in both categories Vitamin D Receptor and Cancer - Ovarian:

This study aimed to investigate vitamin D receptor (VDR) expression levels and evaluate their clinical significance in patients with colorectal cancer (CRC). VDR protein expression was validated by immunohistochemistry in 188 CRC tissues and 134 normal colorectal tissues. The associations between VDR expression and clinicopathologic characteristics, including prognostic outcomes, were analyzed. VDR expression in normal colorectal tissue was higher than that in CRC (83.6% versus 34.6%, P = 4.489 × 10-20) and generated moderate diagnostic performance for CRC detection (AUC = 0.88, sensitivity = 0.87, specificity = 0.84). Low VDR expression was associated with invasion depth (P = 0.001) and poor survival in CRC (P = 0.031). Univariate Cox analysis demonstrated VDR expression (P = 0.036) was a significant prognostic predictor for survival in patients with CRC. Low VDR expression could be a valuable diagnostic and prognostic biomarker for CRC patients. Targeting VDR may offer a potential therapeutic strategy for blocking CRC.


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