Joint association of sedentary behavior and vitamin D status with mortality among cancer survivors
BMC Medicine volume 21, Article number: 411 (2023)
Yu Yu, Sijing Cheng, Hao Huang, Yu Deng, Chi Cai, Min Gu, Xuhua Chen, Hongxia Niu & Wei Hua
Background
Sedentary behavior and vitamin D deficiency are independent risk factors for mortality in cancer survivors, but their joint association with mortality has not been investigated.
Methods
We analyzed data from 2914 cancer survivors who participated in the National Health and Nutrition Examination Survey (2007–2018) and followed up with them until December 31, 2019. Sedentary behavior was assessed by self-reported daily hours of sitting, and vitamin D status was measured by serum total 25-hydroxyvitamin D (25(OH)D) levels.
Results
Among 2914 cancer survivors, vitamin D deficiency was more prevalent in those with prolonged daily sitting time. During up to 13.2 years (median, 5.6 years) of follow-up, there were 676 deaths (cancer, 226; cardiovascular disease, 142; other causes, 308). The prolonged sitting time was associated with a higher risk of all-cause and noncancer mortality, and vitamin D deficiency was associated with a higher risk of all-cause and cancer mortality. Furthermore, cancer survivors with both prolonged sitting time (≥ 6 h/day) and vitamin D deficiency had a significantly higher risk of all-cause (HR, 2.05; 95% CI: 1.54–2.72), cancer (HR, 2.33; 95% CI, 1.47–3.70), and noncancer mortality (HR, 1.91; 95% CI, 1.33–2.74) than those with neither risk factor after adjustment for potential confounders.
Conclusions
In a nationally representative sample of U.S. cancer survivors, the joint presence of sedentary behavior and vitamin D deficiency was significantly associated with an increased risk of all-cause and cancer-specific mortality.
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37+ VitaminDWiki pages have both CANCER and SURVIVE in the title
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Items found: 39
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Colon Cancer survival increases with vitamin D, up to 50 ng – Aug 2024 |
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11 Aug, 2024 |
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Better survival of many cancers if higher level of vitamin D - June 2020 |
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29 Dec, 2023 |
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Much more likely to survive cancer if more than 20 ng of Vitamin D - Oct 2023 |
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31 Oct, 2023 |
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Pancreatic Cancer survival 2.3 X more likely if good level of Vitamin D – meta-analysis Sept 2023 |
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15 Sep, 2023 |
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Breast Cancer survival: 44% with just 10,000 IU of vitamin D per week, 33% with placebo – RCT Dec 2023 |
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13 Aug, 2023 |
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Even after a Cancer diagnosis Vitamin D improves survival – meta-analysis Aug 2022 |
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19 Aug, 2022 |
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Digestive Tract Cancer survival increased 3X if 2,000 IU of vitamin D and have high level of PD-L1 – RCT June 2021 |
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29 Jun, 2021 |
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2 X better survival of digestive cancer if 2,000 IU of Vitamin D plus good VDBP gene – RCT Feb 2020 |
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04 Feb, 2020 |
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Twice as likely to survive Colorectal Cancer if had good level of Vitamin D Binding Protein – July 2019 |
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12 Jul, 2019 |
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Advanced Colorectal Cancer survival is increased somewhat with 4,000 IU of vitamin D – RCT April 2019 |
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10 Apr, 2019 |
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Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018 |
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20 Nov, 2018 |
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Vitamin D reduces the risk of Breast Cancer, improves treatment, and improves survival |
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10 Sep, 2018 |
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Colon Cancer survival increased by MEG3 (MEG3 is increased by Vitamin D in lab) – 2018 |
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31 Mar, 2018 |
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Colon Cancer survival 3.1 X less likely if poor Vitamin D Receptor – Aug 2017 |
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02 Aug, 2017 |
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2X more likely to survive a form of esophageal cancer in China if have good vitamin D receptor – Feb 2017 |
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04 Mar, 2017 |
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Urinary Bladder Cancer survival is associated with vitamin D receptor: 14 months vs 53 months – Oct 2015 |
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02 Mar, 2017 |
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500 Head and neck cancers – higher survival if higher vitamin D – Nov 2016 |
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25 Dec, 2016 |
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Pancreatic Cancer Survival 40 percent more likely if had adequate vitamin D (30 ng) – June 2016 |
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22 Jun, 2016 |
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Cancer risk and survival improved by increasing vitamin D or UVB – April 2016 |
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10 Apr, 2016 |
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Prostate Cancer long term survival 1.7 X more likely if high level of vitamin D – Jan 2016 |
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27 Jan, 2016 |
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7X increase in stage IV Prostate Cancer survival when vitamin D greater than 32 ng – May 2013 |
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27 Jan, 2016 |
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Poor Bladder Cancer survival associated with poor Vitamin D receptor – Oct 2015 |
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18 Oct, 2015 |
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Vitamin D does not improve cancer survival much – when dose size, etc. is ignored – Oct 2015 |
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12 Oct, 2015 |
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Breast Cancer survived much longer if have more than 20 nanograms of vitamin D – Sept 2015 |
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30 Sep, 2015 |
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Ovarian Cancer – 7 percent more likely to survive longer for every 4 ng higher vitamin D – July 2015 |
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12 Sep, 2015 |
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Prostate cancer in veterans more survivable when have enough vitamin D – Jan 2014 |
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26 Mar, 2015 |
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Higher levels of Vitamin D assocated with bladder cancer survival by veterans – Feb 2013 |
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02 Nov, 2014 |
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Cancer (colon, breast, lymph) survival about 2X better with high level vitamin D – meta-analysis July 2014 |
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30 Sep, 2014 |
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Ovarian cancer: more likely to survive if more vitamin D – Aug 2012 |
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23 Jun, 2014 |
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Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014 |
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12 May, 2014 |
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More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014 |
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08 May, 2014 |
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Breast cancer survival increased 2X with lots of vitamin D – 3rd meta-analysis March 2014 |
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08 May, 2014 |
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Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013 |
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06 Mar, 2014 |
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Vitamin D improves Cancer survival – Nov 2013 |
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11 Nov, 2013 |
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Cancer Survival is poor if vitamin D is less than 20ng – review Nov 2013 |
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07 Nov, 2013 |
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Cancer Survival is poor if vitamin D is less than 20ng (every study showed benefit)– review Nov 2013 |
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06 Nov, 2013 |
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2X more likely to survive breast cancer disease free if lots of vitamin D – July 2011 |
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22 Aug, 2012 |
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Surviving Prostate Cancer - Book June 2012 |
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11 Aug, 2012 |
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Children surviving blood cancer and vitamin D levels – Nov 2011 |
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08 Aug, 2012 |
Search 2 words within a category
XX+ VitaminDWiki Mortality pages have CANCER in the title
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3 Cancers have higher mortality if high PTH (which can be lowered by Vitamin D) - Aug 2024 |
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15 Aug, 2024 |
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Fewer deaths (All-cause, Cardiovascular, Cancer) when Vitamin D levels are above 36 ng – April 2024 |
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01 May, 2024 |
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People with Cancer having more than 30 ng of Vitamin D are 40% less likely to die (of any cause) – Nov 2023 |
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23 Nov, 2023 |
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Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013 |
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31 Jul, 2023 |
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Cancer incidence or mortality not changed by small Vitamin D doses: 2021-2023 |
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01 May, 2023 |
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Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018 |
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30 Apr, 2023 |
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Cancer mortality reduced 40 pcnt by 2000 IU Vitamin D daily if normal weight – Meta-analysis June 2022 |
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03 Jul, 2022 |
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Cancer incidence and death reduced by both Vitamin D and UVB – Grant Oct 2021 |
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15 Oct, 2021 |
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Cancer mortality not reduced by small vitamin D doses - Sept 2021 |
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21 Sep, 2021 |
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Cancer death (non-skin) 2.3 X more likely if low Vitamin D – Aug 2021 |
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17 Aug, 2021 |
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Deaths after Cancer Surgery higher in blacks (probably low vitamin D) – Dec 2020 |
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10 Jan, 2021 |
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Cancer patients in ICU with low vitamin D were 3.4 X more likely to die within a year – Dec 2020 |
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31 Dec, 2020 |
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Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020 |
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09 Nov, 2020 |
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Cancer is leading cause of death - Vitamin D and Receptor activators help |
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09 Nov, 2019 |
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Mortality increased: 4X Cancer, 5X Diabetes if eat a lot of meat protein – March 2014 |
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08 Nov, 2019 |
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Vitamin D Supplements Reduce Cancer Mortality – Greger Sept 2019 |
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10 Sep, 2019 |
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Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019 |
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05 Jul, 2019 |
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People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019 |
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05 Jul, 2019 |
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Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019 |
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07 May, 2019 |
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Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019 |
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13 Apr, 2019 |
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Cancer patients 64% less likely to die if have high level of vitamin D – Dec 2011 |
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26 Nov, 2018 |
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Vitamin D reduces the risk of Breast Cancer, improves treatment, and improves survival |
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10 Sep, 2018 |
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The “Deadly Breast Cancer Gene” Is A Myth, Lancet Study Confirms – Jan 2018 |
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13 Jan, 2018 |
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Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017 |
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29 Dec, 2017 |
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Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017 |
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13 Jun, 2017 |
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Death after Breast Cancer 2 times less likely if take lots of Magnesium – Dec 2015 |
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15 Jun, 2016 |
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Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013 |
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09 Nov, 2014 |
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Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014 |
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30 Sep, 2014 |
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Cancer incidence not reduced by 1100 IU of vitamin D (proven again) but mortality decreased – June 2014 |
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17 Jun, 2014 |
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Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014 |
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12 May, 2014 |
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More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014 |
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08 May, 2014 |
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Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014 |
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08 Apr, 2014 |
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Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013 |
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06 Mar, 2014 |
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Vitamin D and Cancer Mortality – review Jan 2013 |
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17 Sep, 2013 |
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Mortality and Cancer varies with latitude in France too – 2010 |
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26 Oct, 2012 |
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More US deaths due to cancer than heart if dark skinned – Sept 2012 |
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18 Sep, 2012 |
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Lack of solar UVB in US is associated with some Cancers - 2006 |
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28 Dec, 2011 |
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Solar radiation, vitamin D and cancer incidence and mortality in Norway |
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13 Apr, 2010 |