Genetic variation in the maternal vitamin D receptor FOKI gene as a risk factor for recurrent pregnancy loss.
J Matern Fetal Neonatal Med. 2019 Aug 25:1-281. doi: 10.1080/14767058.2019.1660768.
Barišić A1, Pereza N1, Hodžić A2, Gašparović Krpina M3, Ostojić S1, Peterlin B2.
1 Faculty of Medicine, University of Rijeka, Department of Medical Biology and Genetics , Rijeka , Croatia.
2 Clinical Institute of Medical Genetics, UMC , Ljubljana , Slovenia.
3 Clinical Hospital Center "Rijeka", Department of Obstetrics and Gynecology , Rijeka , Croatia.
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- Healthy pregnancies need lots of vitamin D
- Ensure a healthy pregnancy and baby - take Vitamin D before conception
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – Meta-Analysis Jan 2021
- Higher risk of Recurrent Pregnancy Loss if poor Vitamin D Receptor – Feb 2021
- Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020
- Preterm birth associated with many genes, including the Vitamin D Receptor again – Jan 2020
- Preterm birth 8X more likely if poor Vitamin D Receptor – Dec 2019
- Preterm birth 9 X more likely if fetus had a poor Vitamin D Receptor and previous miscarriage – Aug 2017
- Recurrent miscarriage occurs 2.2 more often if poor Vitamin D Receptor – Aug 2019
- Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019
- Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019
- Preeclampsia 2X more likely if poor Vitamin D Receptor – April 2019
- Preterm births 12 X more likely if poor Vitamin D Receptor (white infants in Italy) – meta-analysis Aug 2018
- UV at time of conception associated with Vitamin D Receptor activation 65 years later – Sept 2017
- A good Vitamin D Receptor (or perhaps more vitamin D) protects against lead during pregnancy
- Vitamin D Receptor is associated with preeclampsia, gestational diabetes and preterm birth – Nov 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Frequent miscarriage associated with both lower vitamin D and poor Vitamin D receptor – Sept 2017
- Vitamin D genes and pregnancy – 7th study - Sept 2017
- Preterm births strongly related to Vitamin D, Vitamin D Receptor, Iodine, Omega-3, etc
- Recurrent miscarriage associated with half as much vitamin D getting to fetus – Sept 2016
- Progesterone activates vitamin D receptor - many studies
Purpose: Recurrent pregnancy loss (RPL) is a reproductive disorder defined as the loss of two or more pregnancies before 24 weeks of gestation. Despite the fact that several mechanisms have been previously described for the pathogenesis of RPL, the causes of approximately 50% of cases remain unknown. However, recent studies indicate association of vitamin D deficiency with adverse pregnancy outcome, including RPL. The vitamin D receptor (VDR) is a crucial mediator of the pleiotropic cellular effects of vitamin D. Its function is influenced by several single nucleotide polymorphisms (SNPs). The main objective of the present study was to assess whether maternal VDR SNPs are associated with the risk of RPL in Slovenian and Croatian women.
Methods: A case - control study including 320 women with recurrent pregnancy loss and control women was designed to examine the potential association of VDR polymorphisms (FokI rs222857, Cdx2 rs11568820 and Taq1 rs731236) with RPL. Genotyping was performed using polymerase chain reaction and restriction fragment length polymorphism methods.
Results: We found a statistically significant higher frequency of the rs222857 CC genotype (X2 = 6.61, p = 0.036) and C allele (X2 = 5.93, p = 0.015) in RPL women compared to controls. Subsequently, the odds for RPL for the rs222857 were increased under the recessive (CCvsCT + TT: OR = 1.78; 95% CI = 1.12-2.82; p = 0.015) and the codominant (CCvsTT: OR = 2.21; 95% CI = 1.08-4.53; p = 0.029; CCvsCT: OR = 1.68; 95% CI = 1.04-2.72; p = 0.036) genetic models. The other two analyzed polymorphisms did not show any statistical significant result.
Conclusions: Our results suggest that variations in the maternal VDR FokI gene might be associated with RPL in Slovenian and Croatian women.
Vitamin D receptor gene polymorphisms and haplotypes in the etiology of recurrent miscarriages
Sci Rep . 2021 Feb 25;11(1):4646. doi: 10.1038/s41598-021-84317-3.
Hubert Wolski 1 2, Grażyna Kurzawińska 1 3, Marcin Ożarowski 4, Aleksandra E Mrozikiewicz 5, Krzysztof Drews 1, Tomasz M Karpiński 6, Anna Bogacz 7 8, Agnieszka Seremak-Mrozikiewicz 1 3 7
Download the PDF from Reaszrch Gate via VitaminDWiki
A few years ago it was shown that disturbed metabolism of the vitamin D/receptor (VD/VDR) complex may be important in the etiology of spontaneous abortion, as well as in the etiology of recurrent miscarriages (RM). The goal of this study was to investigate the association between four maternal VDR polymorphisms as well as haplotypes settings and RM occurrence in a Polish population of women in reproductive age. A total of 230 women were recruited to this study (110 with RM, 120 consecutively recruited age-matched healthy women with at least two full-term pregnancies and with no history of miscarriages). DNA samples were genotyped for VDR polymorphisms: FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236). Significant differences in genotype distributions and allele frequencies between case and control groups were observed in VDR BsmI polymorphism (GG vs. GA and AA, OR = 0.56, p = 0.036 and OR = 1.49, p = 0.035, respectively). The best evidence of an association with RM prevention was observed for the TTGT haplotype, which was more frequent among controls than cases even after permutation test (0.09 vs. 0.017, p = 0.0024). Other haplotypes were also significantly more frequent in the control group: TGT (rs7975232, rs1544410, rs2228570), TG (rs7975232, rs1544410), TTG (rs731236, rs7975232, rs1544410), TT (rs731236, rs7975232). Our research indicated the possible role of VDR BsmI genetic polymorphism in RM etiology, suggesting at the same time the active role of maternal VD metabolism and its influence on pregnancy outcome. The significant influence of several maternal haplotypes was shown to prevent RM occurrence.Recurrent miscarriage occurs 2.2 more often if poor Vitamin D Receptor – Aug 2019
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