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Tuberculosis increased risk if poor Vitamin D receptor varies by race – meta-analysis Feb 2019

A meta-analysis on associations between vitamin D receptor genetic variants and tuberculosis.

Microb Pathog. 2019 Feb 26. pii: S0882-4010(19)30022-1. doi: 10.1016/j.micpath.2019.02.027.
Wang Y1, Li HJ2.
1 Clinical Laboratory, Huzhou Central Hospital, Huzhou, Zhejiang, China. wytg2019 at sina.com.
2 Clinical Laboratory, Zhuantang Street Community Health Service Center of Xihu District, Hangzhou, Zhejiang, China. hongjieli8896 at 163.com.

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Items in both categories TB and Vitamin D Receptor gene are listed here:

Items in both categories TB and Meta-analysis are listed here:

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Image
OR, odds ratio; CI, confidence interval; NA, not available; PTB, pulmonary tuberculosis; EPTB, extrapulmonary tuberculosis.
The values in bold indicate that there are statistically significant differences between cases and controls.

Abstract
OBJECTIVES: We aimed to analyze potential associations between vitamin D receptor (VDR) genetic variants and tuberculosis (TB) through a meta-analysis.

METHODS: Systematic literature research of PubMed, Web of Science, Embase and CNKI was performed to identify eligible articles. Statistical analyses were conducted by using Review Manager.

RESULTS:
Totally 54 studies were enrolled for analyses. Pooled overall analyses suggested that VDR rs1544410 (dominant model: p = 0.02; allele model: p = 0.04), rs2228570 (recessive model: p = 0.01; allele model: p = 0.03) and rs731236 (recessive model: p = 0.02; allele model: p = 0.02) variants were significantly associated with TB. Further subgroup analyses by ethnicity revealed that rs1544410 variant was significantly associated with TB in South Asians (dominant and allele models) and Caucasians (dominant, recessive and allele models), rs2228570 variant was significantly associated with TB in East Asians (recessive model), and rs731236 variant was significantly associated with TB in South Asians (dominant, recessive and allele models).

CONCLUSIONS: Our meta-analysis suggested that VDR rs1544410, rs2228570 and rs731236 variants might serve as genetic biomarkers of TB in certain populations.

Created by admin. Last Modification: Thursday June 20, 2019 16:40:21 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
12172 TB VDR meta.jpg admin 20 Jun, 2019 16:37 70.43 Kb 66
11491 TB VDR race.jpg admin 02 Mar, 2019 13:19 138.66 Kb 73
11489 TB VDR.pdf PDF 2019 admin 02 Mar, 2019 13:12 456.14 Kb 52
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