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- Vitamin D deficiency and vitamin D receptor FokI polymorphism as risk factors for COVID-19
- VitaminDWiki -
30 studies in both categories Virus and VDR
- VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos
- VitaminDWiki - Vitamin D Receptor activation can be increased in 14 ways
- Diseases associated with a poor Vitamin D Receptor
Pediatr Res. 2022 Sep 9. doi: 10.1038/s41390-022-02275-6
Nancy M S Zeidan 1 , Hanan M Abd El Lateef 2 , Dalia M Selim 2 , Suzan A Razek 2 , Ghada A B Abd-Elrehim 3 , Mohamed Nashat 4 , Noha ElGyar 5 , Nevin M Waked 6 , Attia A Soliman 7 , Ahmed A Elhewala 7 , Mohamed M M Shehab 7 , Ahmed A A Ibraheem 7 , Hassan Shehata 7 , Yousif M Yousif 7 , Nagwa E Akeel 7 , Mustafa I A Hashem 7 , Amani A Ahmed 7 , Ahmed A Emam 8 , Mohamed M Abdelmohsen 9 , Mohamed F Ahmed 9 , Ahmed S E Saleh 10 , Heba H Eltrawy 11 , Gehan H Shahin 12 , Rehab M Nabil 13 , Thoraya A Hosny 13 , Mohamed R Abdelhamed 14 , Mona R Afify 15 , Mohanned T Alharbi 15 , Mohammed K Nagshabandi 15 , Muyassar K Tarabulsi 15 , Sherif F Osman 16 , Amal S M Abd-Elrazek 17 , Manal M Rashad 18 , Sonya A A El-Gaaly 19 , Said A B Gad 20 , Mohamed Y Mohamed 21 , Khalil Abdelkhalek 1 , Aly A Yousef 22
Background: Given the sparse data on vitamin D status in pediatric COVID-19, we investigated whether vitamin D deficiency could be a risk factor for susceptibility to COVID-19 in Egyptian children and adolescents. We also investigated whether vitamin D receptor (VDR) FokI polymorphism could be a genetic marker for COVID-19 susceptibility.
Methods: One hundred and eighty patients diagnosed to have COVID-19 and 200 matched control children and adolescents were recruited. Patients were laboratory confirmed as SARS-CoV-2 positive by real-time RT-PCR. All participants were genotyped for VDR Fok1 polymorphism by RT-PCR. Vitamin D status was defined as sufficient for serum 25(OH) D at least 30 ng/mL, insufficient at 21-29 ng/mL, deficient at <20 ng/mL.
Results: Ninety-four patients (52%) had low vitamin D levels with 74 (41%) being deficient and 20 (11%) had vitamin D insufficiency. Vitamin D deficiency was associated with 2.6-fold increased risk for COVID-19 (OR = 2.6; [95% CI 1.96-4.9]; P = 0.002. The FokI FF genotype was significantly more represented in patients compared to control group (OR = 4.05; [95% CI: 1.95-8.55]; P < 0.001).
Conclusions: Vitamin D deficiency and VDR Fok I polymorphism may constitute independent risk factors for susceptibility to COVID-19 in Egyptian children and adolescents.
Impact: Vitamin D deficiency could be a modifiable risk factor for COVID-19 in children and adolescents because of its immune-modulatory action. To our knowledge, ours is the first such study to investigate the VDR Fok I polymorphism in Caucasian children and adolescents with COVID-19. Vitamin D deficiency and the VDR Fok I polymorphism may constitute independent risk factors for susceptibility to COVID-19 in Egyptian children and adolescents. Clinical trials should be urgently conducted to test for causality and to evaluate the efficacy of vitamin D supplementation for prophylaxis and treatment of COVID-19 taking into account the VDR polymorphisms.
One hundred and eighty patients aged <19 years who were diagnosed to have COVID-19 at the study hospitals were recruited. All patients were laboratory confirmed as SARS-CoV-2 positive by real-time reverse transcriptase polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens.
Patients' COVID-19 illness severity was categorized into moderate, severe, and critical subgroups according to the recently published classification by Chen et al.20
No asymptomatic or mild cases were seen among our cohort.
- (I) Moderate: included (134) cases presented with pneumonia (lower respiratory symptoms plus fever >38 °C and age-specific tachypnea);
- (II) Severe COVID-19: included (31) cases who rapidly develop dyspnea, hypoxia (arterial oxygen saturation <93%), dehydration with feeding difficulty, elevated liver enzymes, disturbed consciousness, coagulation dysfunction;
- (III) Critically ill cases: included (15) patients who required intensive care unit (ICU) monitoring for acute respiratory failure (ARF), mechanical ventilation (partial arterial oxygen pressure/fraction of inspired oxygen PaO2/FiO2 ratio <300 despite oxygen therapy), septic shock, or organ failure.
Patients were admitted within 72 h from onset of fever and cough. Pulmonary high-resolution computed tomographic images were routinely performed for all patients and evaluated by two experienced radiologists (S.F.O. and A.S.M.) who were blinded to the patients' clinical data.
Two hundred healthy children and adolescents of matched age, sex, and season at enrollment who underwent pre-operative assessment for elective surgery at the study hospitals were enrolled as a control group (all tested negative for SARS-Cov2 by RT-PCR and had negative anti-N antibodies test for SARS-Cov2).
All patients and control subjects belong to the same ethnic group: African Caucasian.
Patients with obesity, malnutrition, immunodeficiency, congenital heart disease, malignancy, metabolic diseases, autoimmune disorders, or any chronic debilitating disease were excluded. Those who received vitamin D, calcium, multi-vitamin, or mineral supplementation during the previous 6 months were also excluded.
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30 studies in both categories Virus and VDR
This list is automatically updated
- COVID kids were more likely to have a poor VDR (4.3 X), than low Vitamin D (2.6 X) – Sept 2022
- Cancers are associated with low vitamin D, poor vaccination response and perhaps poor VDR – July 2022
- COVID 3X more likely if a poor Receptor (cells get less Vitamin D from the blood) – July 2022
- Long-COVID is now the biggest COVID concern - many studies
- COVID death 12X more likely if poor Vitamin D Receptor (less D gets to cells) - Oct 2021
- COVID severity, ICU, and mortality all associated with poor vitamin D receptor (but not D, everyone had low D) -Dec 2021
- Different Vitamin D Receptor problems cause different COVID problems - Dec 2021
- COVID-19 severity associated with 3 vitamin D genes – Oct 2021
- Poor Vitamin D receptor blocked Vitamin D from fighting avian influenza viruses (in mice) – July 2021
- Epstein-Barr is yet another virus that deactivates the Vitamin D receptor (COVID later suspected as well)– 2010
- COVID-19 symptoms and comorbidities associated with the type of Vitamin D Receptor – Oct 2021
- Enveloped virus infection (RSV, coronavirus, HIV, etc.) 1.5X more likely if poor Vitamin D Receptor – meta-analysis Dec 2018
- COVID-19 outpatients getting Quercetin nanoemulsion had excellent outcomes (Q increased Vitamin D in cells) – RCT – June 2021
- A virus that most adults have (Cytomegalovirus) decreases the amount of Vitamin D which gets to the cells – Jan 2017
- COVID virus alters the activation of 100 vitamin D related genes in the lung – April 2021
- Common sense COVID-19 risk reduction - masks, social distancing, vitamin D - Oct 2020
- AI is examining 170,000 potential COVID-19 treatments, Vitamin D is one of only 6 found – Sept 4, 2020
- Vitamin D Receptor activation should reduce ARDS associated with COVID-19 - June 2020
- Dengue viral production decreased 1000X if activate Vitamin D Receptor (in lab) – July 2020
- Vitamin D, Quercetin, and Estradiol all increase vitamin D in cells and increase genes which reduce COVID-19 – May 21, 2020
- Quercetin and Vitamin D - Allies Against COVID-19
- Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018
- Hand, foot, and Mouth disease is 14X more likely if poor Vitamin D Receptor – Oct 2019
- Treating herpes reduced incidence of senile dementia by 10 X (HSV1 reduces VDR by 8X) – 2018
- Severe hand, foot, and mouth virus is 2.9 X more likely if poor Vitamin D receptor – Oct 2018
- Hepatitis B virus reduced by 5X the Vitamin D getting to liver cells in the lab – Oct 2018
- Some enveloped virus are 1.2 X more likely if have a poor Vitamin D Receptor -Aug 2018
- Severe Pertussis is 1.5 times more likely if poor vitamin D receptor – Feb 2016
- Dengue Fever associated with poor vitamin D receptor – July 2002
- Dengue virus 2X to 4X more likely if vitamin D receptor gene problems
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Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Butyrate Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activators
Increased risk associated with a poor Vitamin D Receptor
Note: Some diseases reduce VDR activation
those with a * are known to decrease activation
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COVID kids were more likely to have a poor VDR (4.3 X), than low Vitamin D (2.6 X) – Sept 2022
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