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Type 1 diabetes 1.6 times more likely if a Vitamin D Receptor problem – Feb 2017

There are two studies on the page

Association of VDR polymorphisms and type 1 diabetes susceptibility in children: a meta-analysis.

Endocr Connect. 2017 Feb 23. pii: EC-16-0110. doi: 10.1530/EC-16-0110. [Epub ahead of print]

See also VitaminDWiki

Note: Increased Risk = 1.66 is buried deep inside of the PDF, it is highlighted in yellow

Overview Diabetes and vitamin D contains the following summary

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 480 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
    • which are just some of the vitamin D cofactors

Number of articles in both categories of Diabetes and:

  • Dark Skin 23;   Intervention 52;   Meta-analysis 34;   Obesity 28;  Pregnancy 40;   T1 (child) 37;  Omega-3 11;  Vitamin D Receptor 21;  Genetics 11;  Magnesium 19    Click here to see details

Pages listed in BOTH of the categories Diabetes and Vitamin D Receptor

Vitamin D Receptor category has the following
Note that T2 diabetes has a similar increased risk

418 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor.Example: Breast Cancer

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 44 diseases at least double with poor VDR as of Oct 2019  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells
13) Sulfroaphane and perhaps sulfurVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

Increased risk associated with a poor Vitamin D Receptor

Health Problem
50Lyme Disease
28Leprosy - another says 3X
15Chronic Heart Failure
15Temporary hair loss
14Hand, Foot, and Mouth disease
11Metabolic Syndrome
9.6Chronic Periodontitis
   and smoke
8Juvenile Rheumatoid Arthritis
7.6Crohn's disease
7.5Respiratory Tract Infections
5.8Low back pain in athletes
5 Respiratory Distress in preemies
5Ulcerative Colitis
5Coronary Artery Disease
5Asthma Child see also 1.3, 2.0 and 3.6
4.6Breast Cancer 16.9 X another study
4Polycystic ovary syndrome
3.6 Pneumonia - children
3.3 Pre-term birth
3.1 Colon Cancer survival
3 Multiple Sclerosis
3 Waist size
3 Ischemic Stroke
3Gestational Diabetes
2.9Hand, Foot, Mouth Disease
2.8Osteoporosis & COPD
2.7Gastric Cancer
2.6Lupus in children
2.5 Lumbar Disc Degeneration
2.4Lung Cancer
2.2Juvenile idiopathic arthritis
2.1Adolescent idiopathic scoliosis in Asians
2Diabetic Retinopathy
2 Wheezing/Asthma see also 5X
2 Melanoma   Non-melanoma Skin Cancers
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.8Sleep Apnea
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.4Graves Disease
1.4 Rheumatoid arthritis
1.3Childhood asthma see also 5X
1.3Psoriasis in Caucasians
?? Rickets - Vitamin D resistant

 Download the PDF from VitaminDWiki

Sahin O1, Gökşen D2, Ozpinar A3, Serdar M4, Onay H5.
1O Sahin, Pediatrics, Acibadem Universitesi Tip Fakultesi, Istanbul, Turkey ozlemnaciyeatansahin at yahoo.com.
2D Gökşen, Department of Pediatric Endocrinology,, Ege University , Izmir, Turkey.
3A Ozpinar, Biochemistry, Acibadem Universitesi Tip Fakultesi, Istanbul, Turkey.
4M Serdar, Biochemistry, Acibadem Universitesi Tip Fakultesi, Istanbul, Turkey.
5H Onay, Department of Medical Genetics, Ege University Faculty of Medicine, Department of Medical Genetics, Izmir, 35100, Turkey.

There are studies evluating FokI, BsmI, ApaI and TaqI polymorphisms of the vitamin D receptor gene and susceptibility to DM1 (type 1 diabetes mellitus) with controversial results. This present study aims to investigate the association between FokI, ApaI, TaqI and BsmI polymorphisms of vitamin D receptor (VDR) gene and DM1 in children.
A literature search was performed using Medline, EMBASE, Cochrane and Pubmed. Studies were included in the study if at least one of FokI, ApaI, TaqI and BsmI polymorphisms was determined and outcome was DM1 at pediatric age. Data were pooled in a random effects logistic regression model and reported with 95% confidence intervals (95% CI).
A total of 9 studies comprising 1053 patients and 1017 controls met the study inclusion criteria. The pooled odds ratios of the FokI, ApaI, TaqI and BsmI polymorphisms were combined and calculated. Forest plots and funnel plots of the odds ratio value distributions were drawn. Our meta-analysis has demonstrated statistically significant associations between DM1 and VDR genotypes, BsmIBB(P < 0.05), BsmIBb, (P < 0.05), BsmIbb(P < 0.05), TaqITT( P< 0.05) and TaqItt (P < 0.05) in children.
The results indicated that BsmIBB, BsmIBb and TaqItt polymorphisms were associated with an increased risk of DM1, while BsmIbb and TaqITT had protective effect for DM1 in children.

T1 Diabetes and poor Vitamin D Receptor - Dec 2017

 Download the PDF from VitaminDWiki

Attached files

ID Name Comment Uploaded Size Downloads
10387 7104-28276-1-PB.pdf admin 21 Aug, 2018 14:13 538.94 Kb 353
7789 VDR T1 Diabetes.pdf PDF 2017 admin 05 Mar, 2017 17:05 2.14 Mb 382
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