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Asthmatic children 5X more likely to have a poor Vitamin D Receptor – June 2019

The Vitamin D Receptor Gene Polymorphisms in Asthmatic Children: A Case-Control Study

Pediatric Allergy, Immunology, and PulmonologyVol. 32, No. 2 https://doi.org/10.1089/ped.2018.0948
Mehmet Kilic, Sema Ecin, Erdal Taskin, Askin Sen, and Murat Kara


Pages in all 3 categories: Breathing AND Children AND Vitamin D Receptor are listed here:

Pages listed in categories Breathing and Vitamin D Receptor (all ages)

The risk of 40 diseases at least double with poor Vitamin D Receptor as of July 2019

Vitamin D Receptor table shows what compensates for low VDR activation

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Note: Unknown if Asthma ==>Poor VDR or if Poor VDR ==> Asthma

Note: Inhaling Vitamin D is looking promising for various breathing problems as of mid 2019

Background: The association between vitamin D receptor (VDR) polymorphisms and the risk of asthma remains unclear. This study aimed to investigate the effect of VDR gene polymorphisms and VDR mRNA expression levels on respiratory function, nitric oxide levels in expiratory air, and serum vitamin D levels in children with asthma.

Materials and Methods: The study included 80 healthy children (control group) and 100 asthmatic children (asthma group) between the age of 5 and 18 years. The VDR genotypes (ApaI, TaqI, and FokI) and VDR mRNA levels were determined in all groups.

Results: There was no statistically significant difference in vitamin D levels between the asthma group and the control group (P > 0.05). A significant association was found between both

  • genotype (CC) of the TaqI polymorphism [odds ratio (OR) = 0.2, 95% confidence interval (CI) (0.07–0.5), P = 0.003] and
  • genotype (CA) of ApaI polymorphisms [OR = 0.2, 95% CI (0.07–0.8), P = 0.02], and asthma risk.

In addition, when single-nucleotide polymorphism allelic frequencies between asthma and control groups were compared there is no significant association (P > 0.05). When compared to control group, VDR mRNA expression in asthma group decreased in genotypes CC and CA of ApaI and in genotypes TT and TC of TaqI (P < 0.05).

Conclusion: The results provide supporting evidence for an association between TaqI and ApaI polymorphisms and asthma susceptibility.

Created by admin. Last Modification: Friday July 12, 2019 02:20:06 GMT-0000 by admin. (Version 10)
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