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Vitamin D and Ageing (29 page chapter, VDR decreases with age) – Feb 2019

Vitamin D and Ageing

Biochemistry and Cell Biology of Ageing: Part I Biomedical Science pp 191-220
Tom R. Hill. Antoneta Granic, Terence J. Aspray


10 reasons why seniors need more vitamin D has the following

  1. Senior skin produces 3X less Vitamin D for the same sun intensity
  2. Seniors have fewer vitamin D receptors as they age
  3. Seniors are indoors more than than when they were younger
    • not as agile, weaker muscles; frail, no longer enjoy hot temperatures
    • (if outside, stay in the shade), however, seniors might start outdoor activities like gardening, biking, etc.
  4. Seniors wear more clothing outdoors than when younger
    • Seniors also are told to fear skin cancer/wrinkles
  5. Seniors often take various drugs which reduce vitamin D
  6. Seniors often have one or more diseases which consume vitamin D
  7. Seniors generally put on weight at they age - and a heavier body requires more vitamin D
  8. Seniors often (40%) have fatty livers – which do not process vitamin D as well
  9. Reduced stomach acid ==>less Magnesium needed to utilize vitamin D
    (would not show up on vitamin D test)
  10. Seniors with poorly functioning kidneys do not process vitamin D as well
    (would not show up on vitamin D test) 2009 full text online  Also PDF 2009
  11. Vitamin D is not as bioavailable in senior digestive systems (Stomach acid or intestines?)

The risk of 40 diseases at least double with poor Vitamin D Receptor as of July 2019

Vitamin D Receptor table shows what compensates for low VDR activation
Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells
13) Sulfroaphane and perhaps sulfurVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Items in both categories Seniors and Vitamin D Receptor are listed here:

 Download the PDF from Sci-Hub via VitaminDWiki

One hundred years has passed since the discovery of vitamin D as the active component of cod-liver oil which cured the bone disease rickets. Since then our knowledge of vitamin D has expanded tremendously and has included recognition of the importance of UV radiation as a source of the vitamin as well as the discovery of the vitamin as a nutrient, a pro-hormone and a potent steroid hormone with a major role in calcium and bone metabolism. In the last 25 years or so, the discovery of the vitamin D receptor in over 30 different body tissues together with the existence of the alpha-1-hydroxylase enzyme in these tissues provided evidence of a pleiotropic role of vitamin D outside its classical role in the skeleton. These important discoveries have provided the basis for the increasing interest in vitamin D in the context of nutritional requirements for health including the prevention of chronic diseases of ageing. The recent publication of the Dietary Reference Intake report on vitamin D and calcium by the North American Institute of Medicine (IOM) is the most comprehensive report to date on the basis for setting nutritional requirements for vitamin D. This chapter will summarize the nutritional aspects of vitamin D and discuss the changes in vitamin D metabolism and requirements with ageing. It will summarize key evidence on the relationship between vitamin D status and some of the main ageing related health outcomes including bone, muscle and cognitive health as well as survival focusing on the published literature in very-old adults (those >= 85 years of age).

Clipped from PDF

Dermal Vitamin D Production
The dermal capacity to produce vitamin D in persons aged 65 years has been estimated to be about 25% of that in persons aged 20-30 years exposed to the same amount of sunlight (Holick et al. 1989; MacLaughlin and Holick 1985). This reduction cannot be explained by the decrease in mass of the epidermis with ageing, but rather seems to be related to the reduction in the concentration of skin 7-dehydrocholesterol. Other indirect factors which affect exposure to sunlight in older adults include the wearing of more concealing clothing (Matsuoka et al. 1992), an increased use of sunscreen (Holick 1994), and reduced sun exposure, arising from less physical activity and time outdoors compared with younger age groups (Health Survey for England 2008).
Changes in VDR Numbers
Vitamin D deficiency is associated with muscle weakness which potentially increases the risk of falls and fractures, possibly mediated through effects on 1,25(OH)2D3 receptors which have been discovered in muscle (Simpson et al. 1985; Bischoff et al. 2001). Bischoff-Ferrari et al. demonstrated a strong negative correlation between age and VDR expression in muscle as measured by the number of VDR-positive nuclei per 500 counted nuclei (Bischoff-Ferrari et al. 2004). This association was independent of biopsy location and circulating 25(OH)D concentrations. This finding may have significant clinical ramifications in older age owing to the importance of 1,25(OH)2D3 in regulating transcription of muscle related genes. The role of vitamin D in muscle atrophy in older adults has been reviewed by Dawson- Hughes (2012) and will be discussed later in this chapter.

See also VitaminDWiki Aging leads to a decrease of vitamin D getting to cells – Sept 2017

Created by admin. Last Modification: Friday July 12, 2019 02:24:01 GMT-0000 by admin. (Version 8)

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11450 Vit D and ageing book sci-hub.pdf PDF 2019 admin 23 Feb, 2019 13:07 452.02 Kb 439
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