FokI Polymorphism of the Vitamin D Receptor Gene Is Associated with Susceptibility to Gastric Cancer: A Case-Control Study.
Tohoku J Exp Med. 2015;236(3):219-24. doi: 10.1620/tjem.236.219.
Cong L1, Wang WB, Liu Q, Du JJ.
Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong University.
Vitamin D Receptor category has the following
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
A poor VDR increases the risk of 41 health problems click here for details
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:
|1) Vitamin D supplement|
Sun, Ultraviolet -B
| Vitamin D in the blood |
and thus to the cells
|2) Magnesium||Vitamin D in the blood |
AND to the cells
|3) Omega-3||Vitamin D to the cells|
|4) Resveratrol||Vitamin D to the cells|
|5) Intense exercise||Vitamin D Receptor|
|6) Get prescription for VDR activator|
|Vitamin D Receptor|
|7) Quercetin (flavonoid)||Vitamin D Receptor|
|8) Zinc is in the VDR|
Costs less than 1 cent per day
|Vitamin D Receptor|
If poor Vitamin D Receptor
|9.6||Chronic Periodontitis |
|7.5||Respiratory Tract Infections|
|5.8||Low back pain in athletes|
|5||Coronary Artery Disease|
|4||polycystic ovary syndrome|
|3.1||Colon Cancer survival|
|2.8||Osteoporosis & COPD|
|2.6||Lupus in children|
|2.5||Lumbar Disc Degeneration|
|2.1||Adolescent idiopathic scoliosis in Asians|
|2||Melanoma Non-melanoma Skin Cancers|
|1.9||Early tooth decay|
|1.6||Diabetes - Type I|
|1.6||Prostate Cancer while black|
|1.5||Diabetes -Type II|
Vitamin D is a potential protective agent against cancer, and its activity is mediated mainly by vitamin D receptor (VDR). The FokI polymorphism (rs10735810) represents a T-to-C transition (ATG to ACG) in exon 2 of the VDR gene, and this ATG represents the translation-initiation codon, encoded by the f allele. The FokI polymorphism results in the generation of a protein shortened by three amino acids, translated from the downstream ATG codon (the F allele). We investigated the relationship between the FokI polymorphism and gastric cancer in a Chinese Han population. A total of 187 patients and 212 healthy controls were enrolled. The FokI polymorphism was detected by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis. The f allele frequency was higher in patients than that in controls (51.6% and 43.6%, P < 0.05). Multivariate logistics regression analysis revealed patients with the f allele (Ff + ff) showed a higher risk of gastric cancer [odds ratio (95% confidence interval) 2.73 (1.13~4.32)]. Patients with the f allele (Ff + ff) also presented a poorly differentiated type of gastric cancer (P < 0.05) and higher levels of C-reactive protein on admission than the FF group (5.5 ± 2.4 mg/L vs. 3.4 ± 1.3 mg/L, P < 0.05).
Here, we show an association between the VDR FokI polymorphism and the susceptibility to gastric cancer, which may be helpful for early detection of high-risk individuals with the f allele for gastric cancer. Conversely, the F allele may be a protective factor against gastric cancer.
PMID: 26105695 DOI: 10.1620/tjem.236.219