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Crohn’s Disease is associated with poor Vitamin D Receptor (many solutions) – April 2020

Diminished Vitamin D Receptor Protein Levels in Crohn’s Disease Fibroblasts: Effects of Vitamin D

Nutrients 2020, 12(4), 973; https://doi.org/10.3390/nu12040973
Laura Gisbert-Ferrándiz 1,†OrcID,Jesús Cosín-Roger 2,†,Carlos Hernández 2OrcID,Dulce C. Macias-Ceja 2,Dolores Ortiz-Masiá 3,Pedro Salvador 1,Juan V. Esplugues 1,2OrcID,Joaquín Hinojosa 4,Francisco Navarro 4OrcID,Sara Calatayud 1OrcID andMaría D. Barrachina 1,*
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VitaminDWiki

Items in both categories Gut and Vitamin D Receptor are listed here:


Vitamin D Receptor is associated in over 58 autoimmune studies

The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

Resveratrol improves health (Vitamin D receptor, etc.) has the following

  • The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells
  • Resveratrol is one of 11 ways to negate the Vitamin D Receptor restrictions
  • Resveratrol is produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fung
  • Benefits of Reseveratrol, like Vitamin D, appears to be increased when used with other things
    • Quercetin and Curcumin in the case of Resveratro

The articles in both of the categories Resveratrol and Vitamin D Receptor

 Download the PDF from VitaminDWiki

Vitamin D (VD) deficiency has been associated to Crohn’s disease (CD) pathogenesis, and the exogenous administration of VD improves the course of the disease, but the mechanistic basis of these observations remains unknown. Vitamin D receptor (VDR) mediates most of the biological functions of this hormone, and we aim to analyze here the expression of VDR in intestinal tissue, epithelial cells, and fibroblasts from CD patients. The effects of VD on a fibroblast wound healing assay and murine intestinal fibrosis are also analyzed. Our data show diminished VDR protein levels in surgical resections and epithelial cells from CD patients. In intestinal fibroblasts isolated from damaged tissue of CD patients, we detected enhanced migration and decreased VDR expression compared with both fibroblasts from non-damaged tissue of the same CD patient or control fibroblasts. Treatment with VD increased VDR protein levels, avoided the accelerated migration in CD fibroblasts, and prevented murine intestinal fibrosis induced by the heterotopic transplant model. In conclusion, our study demonstrates diminished VDR protein levels associated with enhanced migration in intestinal fibroblasts from damaged tissue of CD patients. In these cells, VD accumulates VDR and normalizes migration, which supports that CD patients would benefit from the VD anti-fibrotic therapeutic value that we demonstrate in a murine experimental model


Created by admin. Last Modification: Wednesday April 29, 2020 22:06:02 GMT-0000 by admin. (Version 3)

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13776 Crohn's VDT intestional.jpg admin 29 Apr, 2020 22:02 15.80 Kb 136
13775 Crohn's and VDR.pdf PDF 2020 admin 29 Apr, 2020 22:02 3.32 Mb 107
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