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Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021

Vitamin D Receptor ( VDR) Gene Polymorphism in Patients Diagnosed with Colorectal Cancer

Nutrients. 2021 Jan 11;13(1):E200. doi: 10.3390/nu13010200.
Maria Latacz 1 2, Dominika Rozmus 1, Ewa Fiedorowicz 1, Jadwiga Snarska 3, Beata Jarmołowska 1, Natalia Kordulewska 1, Huub Savelkoul 4, Anna Cieślińska 1
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VitaminDWiki

The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

Vitamin D Receptor and Cancers

Items in both categories Vitamin D Receptor and Cancer - Breast:

Items in both categories Vitamin D Receptor and Cancer - Colon:

Items in both categories Vitamin D Receptor and Cancer

Items in both categories Vitamin D Receptor and Cancer - other:

Items in both categories Vitamin D Receptor and Cancer - Skin:

Items in both categories Vitamin D Receptor and Cancer - Prostate:

Items in both categories Vitamin D Receptor and Cancer - Ovarian:

 Download the PDF from VitaminDWiki

Colorectal cancer (CRC) is one of the most commonly occurring neoplasias in humans. The prevalence of CRC rates is still rising. Although the exact background of the disease still remains unknown, it is believed that CRC may not only be a result of environmental factors, but also genetic ones. One of the mechanisms underlying CRC might be the vitamin D pathway, as CRC is the most closely linked neoplasia to vitamin D deficiency. This study shows a possible association of the vitamin D receptor (VDR) polymorphisms FokI, BsmI, ApaI, and TaqI with CRC susceptibility. A total of 103 patients diagnosed with CRC (61 men and 42 women, aged 57-82 years) and 109 healthy people (50 men and 59 women, aged 47-68 years) were genotyped using PCR-RFLP for FokI, BsmI, ApaI, and TaqI. None of the single nucleotide polymorphisms (SNPs) individually increased or decreased the risk of CRC.
The evaluation of haplotypes revealed two that might enhance the likelihood of CRC development:

  • taB (OR = 30.22; 95% CI 2.81-325.31; p = 0.01) and
  • tAb (OR = 3.84; 95% CI 1.29-11.38; p = 0.01).

In conclusion, genotyping is an easy and robust procedure that needs to be performed only once in a lifetime. A creation of a relevant SNP's panel might contribute to the identification of the groups that are at the greatest risk of CRC.


Created by admin. Last Modification: Thursday March 11, 2021 22:38:17 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
14871 CRC VDR.jpg admin 15 Jan, 2021 23:36 89.61 Kb 250
14870 nutrients-13-00200.pdf PDF 2021 admin 15 Jan, 2021 23:36 1.21 Mb 88
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