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You will live longer if you have a high level of vitamin D – March 2019

Effect of Genetically Low 25-Hydroxyvitamin D on Mortality Risk: Mendelian Randomization Analysis in 3 Large European Cohorts

Nutrients 2019, 11(1), 74; https://doi.org/10.3390/nu11010074


This Mendelian study used data from "only" ~10,000 people, and was not statistically significant
However, it found trends similar to many meta-analyses
Appears that 40-60 ng level of vitamin D is great
No information for > 60 ng

  • Note: Unaware of any study which also considers the effects of 3 Vitamin D genes on mortality
  • Suspect that death rate is decreased even more if have good gene activation along in addition to high vitamin D level in blood
  • The Vitamin D Receptor is one of 3 genes which are not noticed by a Vitamin D blood test
  • The risk of 40 diseases at least double with poor Vitamin D Receptor as of July 2019

Mortality category in VitaminDWiki starts with:

People die sooner if they have low vitamin D

Mortality is.gd/VitaminDMortality
click on image for details

There are 252 articles in Mortality category

The Meta-analysis of Mortality and Vitamin D are listed here:

 Download the PDF from VitaminDWiki


Thor Aspelund 1,, Martin R. Grübler 3,4,5, Albert V. Smith 1,2, Elias F. Gudmundsson 1, Martin Keppel 6, Mary Frances Cotch 7, Tamara B. Harris 8, Rolf Jorde 9, Guri Grimnes 9, Ragnar Joakimsen 9, Henrik Schirmer 10, Tom Wilsgaard 11, Ellisiv B. Mathiesen 12,13, Inger Njølstad 11, Maja-Lisa Løchen 11, Winfried März 14,15,16, Marcus E. Kleber 14,17, Andreas Tomaschitz 4,18,19, Diana Grove-Laugesen 20, Lars Rejnmark 20, Karin M. A. Swart 21, Ingeborg A. Brouwer 22, Paul Lips 23, Natasja M. Van Schoor 21, Christopher T. Sempos 24, Ramón A. Durazo-Arvizu 25, Zuzana Škrabáková 26, Kirsten G. Dowling 26, Kevin D. Cashman 26,27, Mairead Kiely 26,28, Stefan Pilz 3,21, Vilmundur Gudnason 1,2 and Gudny Eiriksdottir 1,*

The aim of this study was to determine if increased mortality associated with low levels of serum 25-hydroxyvitamin D (25(OH)D) reflects a causal relationship by using a Mendelian randomisation (MR) approach with genetic variants in the vitamin D synthesis pathway. Individual participant data from three European cohorts were harmonized with standardization of 25(OH)D according to the Vitamin D Standardization Program. Most relevant single nucleotide polymorphisms of the genes CYP2R1 (rs12794714, rs10741657) and DHCR7/NADSYN1 (rs12785878, rs11234027), were combined in two allelic scores. Cox proportional hazards regression models were used with the ratio estimator and the delta method for calculating the hazards ratio (HR) and standard error of genetically determined 25(OH)D effect on all-cause mortality. We included 10,501 participants (50.1% females, 67.1±10.1 years) of whom 4003 died during a median follow-up of 10.4 years.
The observed adjusted HR for all-cause mortality per decrease in 25(OH)D by 20 nmol/L was 1.20 (95% CI: 1.15–1.25). The HR per 20 nmol/L decrease in genetically determined 25(OH)D was 1.32 (95% CI: 0.80–2.24) and 1.35 (95% CI of 0.81 to 2.37) based on the two scores.
In conclusion, the results of this MR study in a combined sample from three European cohort studies provide further support for a causal relationship between vitamin D deficiency and increased all-cause mortality. However, as the current study, even with ~10,000 participants, was underpowered for the study of the effect of the allele score on mortality, larger studies on genetics and mortality are needed to improve the precision.

Created by admin. Last Modification: Friday July 12, 2019 02:25:35 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
11622 Mortality F3.jpg admin 21 Mar, 2019 14:24 121.49 Kb 308
11621 Mortality.jpg admin 21 Mar, 2019 14:23 30.44 Kb 273
11620 Mendelian Mortality.pdf PDF 2019 admin 21 Mar, 2019 14:23 580.23 Kb 258
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