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Multiple Sclerosis much more likely if poor Vitamin D Receptor – several studies

Many MS and VDR studies on this page

Predisposing role of vitamin D receptor (VDR) polymorphisms in the development of multiple sclerosis: A case-control study.

J Neurol Sci. 2016 Aug 15;367:148-51. doi: 10.1016/j.jns.2016.05.053. Epub 2016 Jun 1.
Abdollahzadeh R1, Fard MS2, Rahmani F3, Moloudi K4, Kalani BS5, Azarnezhad A6.
1Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
2Department of Immunology, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran; Student research center, Hamadan University of Medical sciences. Hamadan, Iran.
3Department of Medical Biotechnology, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran.
4Department of Radiology and Radiobiology, school of Paramedical Science, Iran University of Medical Sciences, Tehran, Iran.
5Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
6Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Cellular and Molecular research center, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Kurdistan, Iran. Electronic address: Azarnezhad at gmail.com.


Overview MS and vitamin D
Multiple Sclerosis is more likely if poor Vitamin D Receptor (4X Mexico, 3X Iran)– Feb 2017
Receptor Problems are not detected by Vitamin D tests
There are hints that a person has Vitamin D Receptor probems

The articles in both MS and Genetics are:

The articles in both MS and Vitamin D Receptor are:

Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) with a complex etiology. Given the Vitamin D receptor (VDR) gene, it is considered an outstanding risk component associated with MS. The aim of the present study has been to explore and emphasize the role of ApaI, BsmI, TaqI and FokI polymorphisms of VDR gene in susceptibility to MS in an Iranian case-control population including 160 patients and 150 healthy controls. All cases were clinically diagnosed with relapsing-remitting (RR) form, and the controls were age, gender, and race matched which were completely in agreement with the case group. PCR-R FLP was conducted for all the SNPs genotyping. The findings of the study showed a significant difference in allele frequency between the cases and controls for ApaI (p<0.0002), BsmI (p<0.0002) and TaqI (p<0.0001), while no significant difference was observed for FokI (P>0.0125).

The results also showed that

  • AA genotype polymorphism of ApaI and BsmI (OR=4.6 and OR=2.52, respectively),
  • CC genotype of TaqI (OR=2.41) and
  • AC genotype of ApaI (OR=1.79)

are associated with the disease status.
Nevertheless, the results revealed the protective role of TT genotype of TaqI (ORs<1), CC genotype of Apal, and GG genotype of BsmI (ORs<1). VDR polymorphisms seem to have a notable connection with MS pathogenesis, however, study of more big population and functional work on the gene structure and its function are recommended.

PMID: 27423580 DOI: 10.1016/j.jns.2016.05.053

Publisher wants $36 for the PDF

Vitamin D receptor gene polymorphisms are associated with multiple sclerosis in Mexican adults - May 2017

Journal of Neuroimmunology, Volume 306, 15 May 2017, Pages 20–24, https://doi.org/10.1016/j.jneuroim.2017.01.009
Víctor Hugo Bermúdez-Moralesa, Geny Fierrosa, Roberto Lopez Lopeza, Gaby Martínez-Navaa, Mario Flores-Aldanab, José Flores-Riverac, Carlos Hernández-Girónd, ,

Multiple sclerosis (MS) is the most prevalent autoimmune inflammatory demyelinating disease of the central nervous system (CNS) in young adults. More than 50 genomic regions have been associated with MS susceptibility.

Due the important immune-modulating properties of Vitamin D, Vitamin D receptor (VDR) gene polymorphisms – which interfere with the actions of Vitamin D- could be related to increased risk of MS.

We studied 120 patients fulfilling the McDonald criteria for MS (81 females and 39 males) and 180 healthy unrelated controls, nested in a case-Control study, and were recruited from the National Institute of Neurology and Neurosurgery, Manuel Velasco Suárez in Mexico City. Genotyping of VDR gene polymorphisms BsmI (rs1544410) and TaqI (rs731236) was performed using TaqMan SNP Genotyping Assay which consists of a predesigned mix of unlabeled polymerase chain reaction (PCR) primers and the TaqMan minor groove binding group (MGB) probe (FAM dye-labeled).

There was a statistically significant, positive association between MS and the T/T genotype of BsmI polymorphism (OR = 4.15; 95%CI 1.83–9.39), showing also a significant positive trend across genotypes (p < 0.01).
This association was also present evaluating the recessive inheritance model of the polymorphism (OR = 3.91; 95%CI 1.77–8.64). When evaluating the association by alleles, the statistically significant positive association seen by genotypes was confirmed in the T allele carriers, showing an OR of 1.83 (95%CI 1.27–2.65) for MS.

We found a positive association of the genetic VDR polymorphisms TaqI (rs731236) and BsmI (rs1544410), with the risk of MS in a sample of Mexican adults.

VDR and MS-A meta-analysis Aug 2019

Association of Vitamin D Receptor Gene Polymorphisms and the Risk of Multiple Sclerosis-A: Meta Analysis
Archives of Medical Research, https://doi.org/10.1016/j.arcmed.2019.10.007

Previous studies have reported vitamin D receptor (VDR) polymorphisms in multiple sclerosis (MS); however, the results remain contradictory. This study aimed to investigate the association between VDR polymorphisms and the risk of MS.

PubMed and Embase databases were searched to obtain eligible studies. Data were calculated by odds ratios (OR) with 95% confidence intervals (CI).

Twenty seven case–control studies with 4879 MS patients and 5402 controls were included. There was no significant association between ApaI polymorphisms and MS in the overall population. In Asians, no association was found between ApaI polymorphism and MS in the recessive, dominant, Codominant (OR1), Codominant (OR2), Codominant (OR3) models and allele contrast. Similar results were obtained between BsmI polymorphisms and MS. The association between TaqI polymorphism and MS showed significance in the recessive, homozygous, codominant (OR3) models in the overall population and Caucasians. The dominant model showed no association of Taq I polymorphism with MS risk in HLA-DRB1*15-positive and HLA-DRB1*15-negative groups. FokI polymorphism with MS was found in Codominant (OR3) model in the overall population. In Asians, FokI polymorphism showed association with MS in recessive, dominant, Codominant (OR1), Codominant (OR3) models and allele contrast. Subgroup analysis of sex showed no associations between TaqI or FokI polymorphism and MS risk in males or females in all models or allele contrast.

The VDR TaqI polymorphisms showed association with MS risk, especially in Caucasians.
In Asians, ApaI and FokI polymorphisms correlated with MS risk, while BsmI polymorphisms showed no association with MS.
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