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Health problems that run in families are often associated with low vitamin D

"A particular disorder might be described as “running in a family” if more than one person in the family has the condition. Some disorders that affect multiple family members are caused by gene mutations, which can be inherited (passed down from parent to child)." Google

VitaminDWiki realization

  • If a single disease runs in the family it is possible that it is due to a vitamin D gene problem
  • If multiple diseases occur in the family is it likely that they are due to a vitamin D gene problem

I have noticed that many of the health problems prevented/treated by vitamin D seem to run in families.
Here is the first list which I found in Google on family related diseases from The National Institute of Health (US).

Health problem
that runs in family
arthritisRheumatoid Arthritis
blood clotsBlood clotting
heart diseaseCardiovascular
high cholesterolCholesterol
high blood pressureHypertension
pregnancy losses
& birth defects

Genes can make the body less efficient at getting vitamin D to the cells.

  • 2 genes have effects which CAN be detected by vitamin D blood tests.
  • 4 genes have effects which CANNOT be detected by vitamin D blood tests.
  • In either case, if a vitamin D deficiency disease runs in your family you will need more vitamin D than the general population.
    Depending on the gene and the disease, you will need 10% to perhaps 200% larger dose of vitamin D to cancel the gene problem.
    How much more if one specific health problem runs in the family
    How much more vitamin D if several health problems run in the family

Gene studies in VitaminDWiki

Vitamin D Receptor

507 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (21 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (16 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (35 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

How to increase VDR activation

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14)Butyrate especially gutVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

Gene studies of health problems which run in families

Gene studies of other health problems in VitaminDWiki

Also associated with many of the same diseases: Magnesium, Omega-3

Magnesium    Omega-3
The items in both categories of Magnesium and Omega:

See also heritability on VitaminDWiki

Studies which are in both the GENE and Disease categories

Rheumatoid Arthritis

Cancer (not specific cancer category)






Studies which are in both the Vitamin D Receptor and Disease categories

Rheumatoid Arthritis

Cancer (not specific cancer category)






See also web

  • Diseases that run in families not all down to genes, study shows July 2016
    ". . examined the medical histories of more than 500,000 people and their families — including both blood and adoptive relatives."
    . .They looked at incidents of 12 common diseases including high blood pressure, heart disease, and several cancers and neurological diseases."
    "By not accounting for shared environmental factors, scientists may overestimate the importance of genetic variation by an average of 47 per cent, the study found"
  • Fact Sheet: Family History is Important for Health CDC Key Features Dec 2015
    Diseases that occur at an earlier age than expected (10 to 20 years before most people get the disease);
    Disease in more than one close relative;
    Disease that does not usually affect a certain gender (for example, breast cancer in a male);
    Certain combinations of diseases within a family (for example, breast and ovarian cancer, or heart disease and diabetes).
  • Have You Inherited a Vitamin D Deficiency?
    Jan 2016 Susan Rex Ryan

Autoimmune Disease Clusters - which run in families

How do autoimmune diseases cluster in families? A systematic review and meta-analysis - 2013
 Download the PDF from VitaminDWiki
Figure 8 Familial autoimmunity. The vertical axis corresponds to the proband’s disease and each disease individually. In the horizontal axis diseases present in first degree relatives are shown. Each color belongs to the proband’s disease. The figure only includes significant results and may serve as a guide for clinical practice in order to search ADs in FDRs of probands. Note that familial autoimmune disease is excluded.
AA, alopecia areata; AdD, Addison’s disease; AS, ankylosing spondylitis; AITD, autoimmune thyroid disease; CD, celiac disease; CrD, Crohn’s disease; FDR, first degree relative; IBD, inflammatory bowel disease; IIM, idiopathic inflammatory myositis; JDM, juvenile dermatomyositis; JRA, juvenilerheumatoid arthritis; JSLE, juvenile systemic lupus erythematosus; MAS, multiple autoimmune syndrome; MG, myasthenia gravis; MS, multiple sclerosis; PA, pernicious anemia; PAN, polyarteritis nodosa; PBC, primary biliary cirrhosis; PSO, psoriasis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; SS, Sjögren’s syndrome; SSc, systemic sclerosis; T1D, type 1 diabetes; UC, ulcerative colitis; VIT, vitiligo; WG, Wegener’s granulomatosis.

This study was cited by 57 other publications in Google Scholar as of July 2016 such as:

  • Hashimoto thyroiditis: clinical and diagnostic criteria
  • Diagnosis and classification of autoimmune diabetes mellitus
  • Pathogenesis and prevention of rheumatic disease: focus on preclinical RA and SLE
  • Systemic sclerosis at the crossroad of polyautoimmunity
  • New insights into an autoimmune mechanism, pharmacological treatment and relationship between multiple sclerosis and inflammatory bowel disease
  • The diagnosis and clinical significance of polyautoimmunity
  • Is narcolepsy a classical autoimmune disease?
  • Associated autoimmune diseases in children and adolescents with type 1 diabetes mellitus (T1DM)
  • Identification of a new disease cluster of pemphigus vulgaris with autoimmune thyroid disease, rheumatoid arthritis, and type I diabetes

More on this topic at Autoimmune disease clusters run in families (polyautoimmunity) are associated with low vitamin D

Health problems that run in families are often associated with low vitamin D        
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Attached files

ID Name Comment Uploaded Size Downloads
6903 Cluster F8.jpg admin 23 Jul, 2016 26.84 Kb 8762
6902 Autoimmune cluster T1.jpg admin 23 Jul, 2016 77.17 Kb 2756
6901 Autoimmune cluster in families - 2013.pdf admin 23 Jul, 2016 3.05 Mb 1289