"A particular disorder might be described as “running in a family” if more than one person in the family has the condition. Some disorders that affect multiple family members are caused by gene mutations, which can be inherited (passed down from parent to child)." Google
VitaminDWiki realization
- If a single disease runs in the family it is possible that it is due to a vitamin D gene problem
- If multiple diseases occur in the family is it likely that they are due to a vitamin D gene problem
Table of contents
- Every single health problem in this list is strongly related to vitamin D deficiency.
- Genes can make the body less efficient at getting vitamin D to the cells.
- Gene studies in VitaminDWiki
- Vitamin D Receptor
- 55 health problems associated with poor VDR
- How to increase VDR activation
- Gene studies of health problems which run in families
- Gene studies of other health problems in VitaminDWiki
- Also associated with many of the same diseases: Magnesium, Omega-3
- See also heritability on VitaminDWiki
- Studies which are in both the GENE and Disease categories
- Studies which are in both the Vitamin D Receptor and Disease categories
- See also web
- Autoimmune Disease Clusters - which run in families
Every single health problem in this list is strongly related to vitamin D deficiency.
I have noticed that many of the health problems prevented/treated by vitamin D seem to run in families.
Here is the first list which I found in Google on family related diseases from The National Institute of Health (US).
Health problem that runs in family | VitaminDWiki
|
alzheimer's/dementia | Alzheimers |
arthritis | Rheumatoid Arthritis |
asthma | Asthma |
blood clots | Blood clotting |
cancer | Cancer |
depression | Depression |
diabetes | Diabetes |
heart disease | Cardiovascular |
high cholesterol | Cholesterol |
high blood pressure | Hypertension |
pregnancy losses & birth defects | Pregnancy |
stroke | Stroke |
Genes can make the body less efficient at getting vitamin D to the cells.
- 2 genes have effects which CAN be detected by vitamin D blood tests.
- 4 genes have effects which CANNOT be detected by vitamin D blood tests.
- In either case, if a vitamin D deficiency disease runs in your family you will need more vitamin D than the general population.
Depending on the gene and the disease, you will need 10% to perhaps 200% larger dose of vitamin D to cancel the gene problem.
Unknowns
How much more if one specific health problem runs in the family
How much more vitamin D if several health problems run in the family
Gene studies in VitaminDWiki
- Benefits of Vitamin D often limited by genes
- Some of Us May Need More Vitamin D Than Others - Sept 2015
includes information on various genetic testing and add-on services - Common Vitamin D gene variants and resulting diseases – Jan 2013
- Genes (CYP2R1 and GC) which restrict the amount of Vitamin D which gets into bloodstream – June 2014
- Increased mortality associated with low vitamin D genes – Nov 2014
- Many autoimmune diseases associated with latitude and vitamin D receptor – March 2016
- Role of Vitamin D in human Diseases and Disorders – An Overview – DBP, VDR June 2014
- Blood tests can be a poor measure of actual vitamin D due to D Binding Protein (DBP) – May 2014
- Genes and Vitamin D
343 items - Vitamin D Binding Protein
178 items Vitamin D Receptor
530 studies in Vitamin D Receptor category Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
See also:
A poor VDR restricts Vitamin D from getting in the cells48 studies in the Resveratrol category It appears that 30% of the population have a poor VDR (40% of the Obese )
Health problems include: Autoimmune (
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems19 studies), Breast Cancer ( 24 studies), Colon Cancer ( 13 studies), Cardiovascular ( 23 studies), Cognition ( 16 studies), Diabetes ( 24 studies), Hypertension ( 9 studies), Infant ( 22 studies), Lupus ( 6 studies), Metabolic Syndrome ( 4 studies), Mortality ( 4 studies), Multiple Sclerosis ( 14 studies), Obesity ( 17 studies), Pregnancy ( 24 studies), Rheumatoid Arthritis ( 10 studies), TB ( 8 studies), VIRUS ( 37 studies), Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDRVDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:Increasing Increases 1) Vitamin D supplement Sun
Ultraviolet -BVitamin D in the blood
and thus in the cells2) Magnesium Vitamin D in the blood
AND in the cells3) Omega-3 Vitamin D in the cells 4) Resveratrol Vitamin D Receptor 5) Intense exercise Vitamin D Receptor 6) Get prescription for VDR activator
paricalcitol, maxacalcitol?Vitamin D Receptor 7) Quercetin (flavonoid) Vitamin D Receptor 8) Zinc is in the VDR Vitamin D Receptor 9) Boron Vitamin D Receptor ?,
etc10) Essential oils e.g. ginger, curcumin Vitamin D Receptor 11) Progesterone Vitamin D Receptor 12) Infrequent high concentration Vitamin D
Increases the concentration gradientVitamin D Receptor 13) Sulfroaphane and perhaps sulfur Vitamin D Receptor 14) Butyrate especially gut Vitamin D Receptor 15) Berberine Vitamin D Receptor Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Gene studies of health problems which run in families
- Alzheimer’s Alzheimer’s Disease is associated with genes which restrict vitamin D – Aug 2015
- Rheumatoid arthritis Rheumatoid arthritis is 40 percent more likely if vitamin D Receptor problem – 2 meta-analyses 2015
- Asthma 2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015
- Asthma Strong Vitamin D deficiency associations in Asthma patients – Nov 2014
- Cancers Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014
- Cancer - Breast Breast Cancer rate reduced 72 percent by vitamin D gene polymorphism CYP24A1 – Nov 2014
- Cancer - Bladder Poor Bladder Cancer survival associated with poor Vitamin D receptor – Oct 2015
- Cancer - Colon Colon cancer 30 percent more likely if problems with Vitamin D genes CYP24A1 or CYP27B1 – Nov 2015
- Cancer - Pancreatic Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014
- Cancer - Melanoma Melanoma risk 2X to 4X higher if Vitamin D receptor genes had morphed – March 2014
- Cardiovascular Potential for vitamin D receptor agonists in the treatment of cardiovascular disease
- T2 Diabetes Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
- T1 Diabetes Type 1 diabetes associated with faulty Vitamin D receptor genes – May 2013
- Hypertension Hypertension associated with genes which reduce vitamin D – meta-analysis June 2014
- Lupus If Lupus in family – 5 times more likely to get Lupus if low vitamin D and poor CYP24A1 – June 2016
- Stroke Ischemic Stroke 3X more likely if Vitamin D Receptor gene change (Fok 1) – Jan 2014
Gene studies of other health problems in VitaminDWiki
- Lungs with cystic fibrosis fail to activate vitamin D (poor CYP27B) – Feb 2016
- Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015
- Genes make Multiple Sclerosis 2X more likely unless get more vitamin D - Aug 2015
- 2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis Aug 2014
- Multiple Sclerosis patients need more vitamin D to get same blood level response – Aug 2015
- Gene makes COPD 2.6X more likely unless get more vitamin D – meta-analysis Dec 2014
- Obesity strongly associated with vitamin D receptor in Saudia Arabia – July 2014
- Osteoporosis 2.8 X more likely if Vitamin D receptor (VDR) genes altered – Aug 2013
- Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015
- 2 Genes make AMD 6X more likely if low vitamin D - Aug 2015 Age related Macular Degeneration
- Tuberculosis, Genes, Vitamin D Binding Protein, and RCT – Review Aug 2014
- Hip Fracture 2.5 times more likely if poor Vitamin D Binding Protein gene - Aug 2015
Also associated with many of the same diseases: Magnesium, Omega-3
Magnesium Omega-3
The items in both categories of Magnesium and Omega:- Vitamin D, Omega-3, and Magnesium are synergistic - many studies
- Top 3 Supplements to Regenerate Stem Cells and Live Longer (Vitamin D, Omega-3, Magnesium) - video July 2024
- These 3 supplements are a no brainer (Vitamin D, Magnesium, Omega-3) - video July 2024
- Which supplements are often taken for healing hairline bone fractures
- Reduce aging with Vitamin D, Omega-3, Magnesium and Exercise (Patrick video) - March 2024
- How Vitamin D, Omega-3s, and Exercise May Increase Longevity - Patrick Nov 2023
- Longevity experts take Vitamin D, Omega-3, and Magnesium - Patrick video Sept 2023
- increased Periodontal Disease risk if low Vitamin D, Magnesium, Omega-3 - GRH March 2023
- Anxiety, depression, and suicide have recently surged (Note: Vitamin D, Omega-3, and Magnesium help) – May 2022
- Excellent reviews of supplements at ConsumerLab
- Cluster Headaches treated by high-dose Vitamin D, etc. (interview and transcript) - Feb 2022
- Nutritional supplementation during COVID hospitalization helped - RCT - Jan 2022
- Mental health not helped by vitamin D monotherapy (adding Omega-3 and Magnesium help) – review Nov 2021
- Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies
- How Vitamin D, Magnesium, Omega-3 and Zinc prevent and treat COVID-19 etc. – June 2021
- COVID-19 Cytokine storms attenuated by Vitamin D, Omega-3, Mg, Resveratrol, etc – April 2021
- Pregnancy recommendations – huge differences in Vitamin D, Mg, iron, Iodine, DHA, etc – April 2021
- ADHD risk factors include low Zinc, Vitamin D, Magnesium and Omega-3 (umbrella review) – Oct 2020
- Less muscle loss associated with eating more fish (Omega-3, Vitamin D, Magnesium, etc) – Jan 2020
- Depression treatments: diet, exercise, bright light, Vitamin D, B12, Omega-3, Zinc, Music, etc. – May 2019
- Magnesium, Vitamin D, Omega-3, TSH - importance and testing - Dean and Baggerly - Oct 2019
- Metabolic Syndrome risk reduced 3.7 X by nuts (Magnesium, Omega-3) – Dec 2018
- Behavior disorders reduced with Magnesium, Omega-3, and Zinc
- Supplements taken by US Adults, Grassroots Health – March 2019
- Less DNA repair if nutrient deficient (Vitamin D, Magnesium, Omega-3, Vitamin K, etc) – Ames Oct 2018
- Bulk supplementation of Vitamin D, Magnesium, Zinc, B-12, K2, Boron etc. - lower cost and easier than pills
- Vitamin D monotherapy is good, Vitamin D multitherapy is great
- Health problems prevented by eating nuts (perhaps due to Magnesium and or Omega-3) – meta-analysis Dec 2016
- Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016
- Cardiovascular calcification prevented by Omega-3, Magnesium, Vitamin K, and Vitamin D – April 2015
- Vitamin D Cofactors in a nutshell
- Supplements survey: Fish oil 1st, Vitamin D 4th, Magnesium 6th, Calcium 7th - March 2015
- Cluster headaches virtually eliminated in 7,000 people with high-dose vitamin D and cofactors - Feb 2022
- How much vitamin D and other nutrients do I take
- Heart problems such as Afib related to little Magnesium, Omega-3, Vitamin D getting to tissues
- A balanced diet is no longer enough – supplements needed - VitaminDWiki Oct 2012
- Vitamin and Mineral deficiencies – Ames Triage Theory Sept 2012
- Reasons for low response to vitamin D
- Low cost cofactors for vitamin D
See also heritability on VitaminDWiki
- Majority of heritable diseases are associated with vitamin D (from 4 million health records) – July 2016
- Vitamin D insufficiency in child 15X more likely if father is Vitamin D insufficient – June 2021
- Vitamin D Heritability: twin studies – 20 percent to 85 percent, GWAS 5 percent – Oct 2018
- Does survival of the less fit mean less health (poor genes may be inherited)
Studies which are in both the GENE and Disease categories
Rheumatoid Arthritis
Cancer (not specific cancer category)
- 100 years since the discovery of Vitamin D - 23 studies - 2022, 2023
- Changes in CYP3A4 gene affects Vitamin D, health, reactions to some drugs, etc - June 2022
- Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018
- Fight Cancer with more than cut, burn, and poison – Nobel prize for T-Cell – Oct 2018
- Role of Vitamin D in human Diseases and Disorders – An Overview – DBP, VDR June 2014
- The Anti-cancer Actions of Vitamin D – Jan 2013
- How Vitamin D prevents many cancers (c-MYC) – Nov 2012
- CYP24A1 gene in cancer cells may actually remove vitamin D from the blood – Oct 2012
- Possible ways that vitamin D does its magic
Diabetes
- DNA analysis of genes (Polygenic risk) shows increased risk of 9 health problems (all 9 fought by Vitamin D) – Feb 2024
- Increased Phosphorus increases Vitamin D getting to cells (CYP24A1, pigs) - Aug 2022
- Increased risk of diabetes if have poor Vitamin D genes – Dec 2020
- Poor CYP2R1 gene results in lower vitamin D and 2X increase in T1 Diabetes – Sept 2019
- Fasting and Diabetes both reduce Vitamin D activation (CYP2R1 in rodents) – May 2019
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Diabetes changes liver genes so as to destroy (catabolize) Vitamin D – May 2016
- Low vitamin D in pregnancy – epigenetic pancreas problems in offspring (mice) – May 2016
- Diabetics with 8ng less vitamin D had a 50 percent increase chance of DHCR7 gene variation – Jan 2014
- Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
- Fructose reduces blood levels of active vitamin D
- Type 1 diabetes, genes and vitamin D
- Vitamin D genes and insulin resistance – MS Aug 2010
Cardiovascular
- DNA analysis of genes (Polygenic risk) shows increased risk of 9 health problems (all 9 fought by Vitamin D) – Feb 2024
- High dose vitamin D fights Folate gene changes by COVID, autoimmune, CVD, ALZ – Oct 2022
- Acute Coronary Syndrome is associated with poor Vitamin D genes (CYP27B1, CYP24A1) – Nov 2019
- Afib increase by 3X for the 1 in 16 people having poor genes (example of health problem) – Aug 2018
Hypertension
- Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022
- Hypertension 2X more likely if poor CYP24A1 vitamin D gene (China) – Jan 2020
- Hypertension 3.1 X more likely in males with poor CPY24A1 gene (but 2.5 X less likely for females) – May 2019
- Hypertension gene expression reduced by high-dose vitamin D (hypertensive rats) – March 2019
- Hypertension associated with genes which reduce vitamin D – meta-analysis June 2014
Pregnancy
- Gestational Diabetes and Vitamin D - many studies
- Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022
- Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020
- 430 genes changed when 3,800 IU Vitamin D added in late second trimester – RCT May 2018
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Pregnant women need at least 40 ng of Vitamin D (Wagner, genes) – Oct 2017
- Vitamin D genes and pregnancy – 7th study - Sept 2017
- Vitamin D during pregnancy – dramatic changes in both metabolism and genes – Feb 2017
- 5839 genes changed during pregnancy (many genes were related to Vitamin D) – Oct 2016
- Preeclampsia 3.5 times more likely if low vitamin D (affects 348 Vit. D genes) – RCT Nov 2016
- Low vitamin D in pregnancy – epigenetic pancreas problems in offspring (mice) – May 2016
- Low vitamin D in mother rat altered 426 genes in newborn rat – Aug 2013
Stroke
Studies which are in both the Vitamin D Receptor and Disease categories
Rheumatoid Arthritis
- Adaptive and innate immune system, vitamin D genes, and Rheumatoid Arthritis – June 2019
- Resveratrol Role in Autoimmune Disease-A Mini-Review. – Dec 2016
- Immunological effects of vitamin D and their relations to autoimmunity – March 2019
- Arthritis runs in Pakistani families (Vitamin D Receptor) – March 2019
- Juvenile idiopathic arthritis 2.2 X more likely if poor Vitamin D Receptor – Aug 2018
- Juvenile Rheumatoid Arthritis 8 X more likely if poor Vitamin D receptor – Dec 2017
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Vitamin D in rheumatoid arthritis-towards clinical application – April 2016
- Rheumatoid arthritis is 40 percent more likely if vitamin D Receptor problem – 2 meta-analyses 2015
- Rheumatoid arthritis, genes and vitamin D – May 2013
Cancer (not specific cancer category)
- 100 years since the discovery of Vitamin D - 23 studies - 2022, 2023
- Cancers are associated with low vitamin D, poor vaccination response and perhaps poor VDR – July 2022
- Poor prognosis of solid childhood cancers 14.7 X more likely with a poor Vitamin D Receptor – July 2022
- Cancers and Vitamin D Receptors, including change with race – Feb 2021
- Needing a high level of vitamin D is a good clue that the Vitamin D Receptor is deactivated
- Vitamin D Receptor (Cancers OR Viruses) - many studies
- Book: Sunlight, UV, Vitamin D and Receptor, Skin and other Cancers - Dec 2020
- How cancer is fought by Vitamin D (Ovarian this time) – Feb 2020
- 8 ways that Cancer might be prevented by Vitamin D - June 2019
- Cancer is leading cause of death - Vitamin D and Receptor activators help
- The Role of Resveratrol in Cancer Therapy – Dec 2017
- A poor Vitamin D Receptor is associated with many cancers (oral cancer in this case) – Jan 2019
- Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
- Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018
- Vitamin D receptor is essential for both normal and cancerous cells in the lab – June 2018
- Active Vitamin D reduces Ovarian Cancer stem cells growth by 4X (via Vitamin D receptor in lab rat) – March 2018
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Cancer risks and Vitamin D Receptors – association is unclear – 2017
- Vitamin D, Vitamin D Receptor and Cancer – Nov 2016
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Role of Vitamin D in human Diseases and Disorders – An Overview – DBP, VDR June 2014
- Vitamin D Receptor role in Autoimmune Diseases and or cancers – Nov 2013
- Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014
Diabetes
- T2 Diabetes might be fought by Vitamin D plus Vitamin D Receptor activators – April 2023
- Diabetes 3X more likely if had COVID ICU (VDR was deactivated) - April 2023
- T2 diabetes complications increased 35-52 percent if low vitamin D – Sept 2022
- T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- Type 1 Diabetes (Autoimmune) and Vitamin D, Vitamin D Receptor and Cathelicidin - Dec 2020
- Diabetes decreased by activating Vitamin D Receptor (transgenic mice) – Feb 2020
- Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019
- Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019
- Resveratrol prevented bone loss associated with T2DM (probably via VDR) – RCT Sept 2018
- Diabetic nephropathy deactivates the Vitamin D Receptor, reducing tissue Vit D – Feb 2019
- Resveratrol improves health (Vitamin D receptor, etc.) - many studies
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Type 1 Diabetes 14 percent more likely with 2 Vitamin D Receptor mutations – Oct 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017
- Type 1 Diabetes association with poor Vitamin D Receptor: 39 studies – April 2017
- Type 1 diabetes 1.6 times more likely if a Vitamin D Receptor problem – Feb 2017
- Diabetic Retinopathy 2 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2016
- Diabetic foot ulcer 1.7 times more likely if poor Vitamin D Receptor – Jan 2017
- Vitamin D activates the hypothalamus (in rodents) to reduce weight and diabetes– May 2016
- Diabetes (T2) 16 percent more likely if Vitamin D receptor problem – Oct 2015
- Type 1 diabetes associated with faulty Vitamin D receptor genes – May 2013
- Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
Cardiovascular
- 4 Cardiovascular diseases are associated with little vitamin D getting to cells – May 2023
- Cardiovascular disease 2.3 X more-likely if poor Vitamin D Receptor – Aug 2022
- Resveratrol and Cardiovascular Diseases – May 2016
- Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
- Potential for vitamin D receptor agonists in the treatment of cardiovascular disease
Hypertension
- 4 Cardiovascular diseases are associated with little vitamin D getting to cells – May 2023
- Health problems running in family may be due to poor vitamin D (hypertension, VDR in this case) Sept 2022
- Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022
- Preeclampsia reduced by Vitamin D - many studies
- Hypertension risk increased 2.1 X if poor Vitamin D Receptor – Dec 2019
- Helicobacter pylori infection and low vitamin D – several studies
- Hypertension, Vitamin D, and Vitamin D Receptor – Aug 2019
- Preeclampsia 2X more likely if poor Vitamin D Receptor – April 2019
- Hypertension, Vitamin D Receptor, and FokI gene – Editorial Aug 2014
Pregnancy
- Gestational Diabetes and Vitamin D - many studies
- Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022
- Preeclampsia reduced by Vitamin D - many studies
- After lactation Vitamin D levels are low, increased risk of Breast Cancer, vitamin D should decrease risk – Aug 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- Higher risk of Recurrent Pregnancy Loss if poor Vitamin D Receptor – Feb 2021
- Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020
- Preterm birth associated with many genes, including the Vitamin D Receptor again – Jan 2020
- Preterm birth 8X more likely if poor Vitamin D Receptor – Dec 2019
- Preterm birth 9 X more likely if fetus had a poor Vitamin D Receptor and previous miscarriage – Aug 2017
- Recurrent miscarriage occurs 2.2 more often if poor Vitamin D Receptor – Aug 2019
- Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019
- Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019
- Preeclampsia 2X more likely if poor Vitamin D Receptor – April 2019
- Preterm births 12 X more likely if poor Vitamin D Receptor (white infants in Italy) – meta-analysis Aug 2018
- UV at time of conception associated with Vitamin D Receptor activation 65 years later – Sept 2017
- A good Vitamin D Receptor (or perhaps more vitamin D) protects against lead during pregnancy
- Vitamin D Receptor is associated with preeclampsia, gestational diabetes and preterm birth – Nov 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Frequent miscarriage associated with both lower vitamin D and poor Vitamin D receptor – Sept 2017
- Vitamin D genes and pregnancy – 7th study - Sept 2017
- Preterm births strongly related to Vitamin D, Vitamin D Receptor, Iodine, Omega-3, etc
- Recurrent miscarriage associated with half as much vitamin D getting to fetus – Sept 2016
- Progesterone activates vitamin D receptor - many studies
Stroke
- Resveratrol improves health (Vitamin D receptor, etc.) - many studies
- Cerebral small vessel disease 2.5 X more likely if poor Vitamin D Receptor – Sept 2018
- Ischemic Stroke 3X more likely if Vitamin D Receptor gene change (Fok 1) – Jan 2014
- Ischemic stroke 2X more likely if Vitamin D Receptor gene problem – Dec 2014
See also web
- Diseases that run in families not all down to genes, study shows July 2016
". . examined the medical histories of more than 500,000 people and their families — including both blood and adoptive relatives."
. .They looked at incidents of 12 common diseases including high blood pressure, heart disease, and several cancers and neurological diseases."
"By not accounting for shared environmental factors, scientists may overestimate the importance of genetic variation by an average of 47 per cent, the study found" - Fact Sheet: Family History is Important for Health CDC Key Features Dec 2015
Diseases that occur at an earlier age than expected (10 to 20 years before most people get the disease);
Disease in more than one close relative;
Disease that does not usually affect a certain gender (for example, breast cancer in a male);
Certain combinations of diseases within a family (for example, breast and ovarian cancer, or heart disease and diabetes). - Have You Inherited a Vitamin D Deficiency?
Jan 2016 Susan Rex Ryan
Autoimmune Disease Clusters - which run in families
- Video by Dr. Coimbra – 95 percent of auto-immune cured with vitamin D in high doses - April 2014
- Do Autoimmune Diseases Run in Families? HealthCentral 2013
" . . autoimmune diseases which tend to cluster (aggregate) in our families."
"Familial autoimmunity was investigated in five major autoimmune diseases: rheumatoid arthritis, systemic lupus erythematosus, autoimmune thyroid disease, multiple sclerosis, and type 1 diabetes mellitus. "
Example: familial autoimmunity in Graves’ disease 14 X more likely to have family members to have pernicious anemia or RA
How do autoimmune diseases cluster in families? A systematic review and meta-analysis - 2013
 Download the PDF from VitaminDWiki
Figure 8 Familial autoimmunity. The vertical axis corresponds to the proband’s disease and each disease individually. In the horizontal axis diseases present in first degree relatives are shown. Each color belongs to the proband’s disease. The figure only includes significant results and may serve as a guide for clinical practice in order to search ADs in FDRs of probands. Note that familial autoimmune disease is excluded.
AA, alopecia areata; AdD, Addison’s disease; AS, ankylosing spondylitis; AITD, autoimmune thyroid disease; CD, celiac disease; CrD, Crohn’s disease; FDR, first degree relative; IBD, inflammatory bowel disease; IIM, idiopathic inflammatory myositis; JDM, juvenile dermatomyositis; JRA, juvenilerheumatoid arthritis; JSLE, juvenile systemic lupus erythematosus; MAS, multiple autoimmune syndrome; MG, myasthenia gravis; MS, multiple sclerosis; PA, pernicious anemia; PAN, polyarteritis nodosa; PBC, primary biliary cirrhosis; PSO, psoriasis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; SS, Sjögren’s syndrome; SSc, systemic sclerosis; T1D, type 1 diabetes; UC, ulcerative colitis; VIT, vitiligo; WG, Wegener’s granulomatosis.This study was cited by 57 other publications in Google Scholar as of July 2016 such as:
- Hashimoto thyroiditis: clinical and diagnostic criteria
- Diagnosis and classification of autoimmune diabetes mellitus
- Pathogenesis and prevention of rheumatic disease: focus on preclinical RA and SLE
- Systemic sclerosis at the crossroad of polyautoimmunity
- New insights into an autoimmune mechanism, pharmacological treatment and relationship between multiple sclerosis and inflammatory bowel disease
- The diagnosis and clinical significance of polyautoimmunity
- Is narcolepsy a classical autoimmune disease?
- Associated autoimmune diseases in children and adolescents with type 1 diabetes mellitus (T1DM)
- Identification of a new disease cluster of pemphigus vulgaris with autoimmune thyroid disease, rheumatoid arthritis, and type I diabetes
More on this topic at Autoimmune disease clusters run in families (polyautoimmunity) are associated with low vitamin DHealth problems that run in families are often associated with low vitamin D37550 visitors, last modified 20 Aug, 2023, This page is in the following categories (# of items in each category)Attached files
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