Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus
Cureus 17(2): e78830. doi:10.7759/cureus.78830
Oana Raluca Predescu • Florentin Ananu Vreju • Anca Emanuela Musetescu • Alesandra Florescu • Stefan Cristian Dinescu • Cristina Elena Bita • Andreea Lili Barbulescu • Paulina Lucia Ciurea
less fatigue, but little reduction is Lupus disease activity
Note: Other Lupus studies have found that the Vitamin D Receptor needs activation
by VDR activators or weekly instead of daily Vitamin D
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic inflammation and various clinical symptoms, with vitamin D deficiency suggested as a contributing factor. This study aimed to evaluate the effects of vitamin D supplementation on fatigue and disease activity in SLE patients.
Methods: Patients diagnosed based on EULAR/ACR 2019 criteria were divided into three groups: no supplementation, 4000 IU, and 8000 IU of vitamin D daily for six months. Clinical assessments included serum complement levels (C3 and C4),
- fatigue scores (Functional Assessment of Chronic Illness Therapy (FACIT)
- Fatigue and Fatigue Severity Scale (FSS), and
- disease activity (Safety of Estrogens in Lupus Erythematosus National Assessment-Systemic Lupus Erythematosus Disease Activity Index (SELENA-SLEDAI).
Results: Results showed significant increases in vitamin D levels and serum complement levels in the supplementation groups. Serum complement levels and fatigue scores improved significantly in both the 4000 IU and 8000 IU groups. Additionally, there was a slight reduction in SELENA-SLEDAI scores in the treated groups, but without statistical significance.
Conclusions: The findings suggest that vitamin D supplementation positively affects fatigue and some parameters of disease activity in SLE patients, though its overall impact on disease activity needs further investigation.
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VitaminDWiki – Lupus category contains
Some of the studies in VitaminDWiki
- Every aspect of Lupus is associated with low viramin D – Oct 2021
- It is time to routinely give vitamin D to Lupus patients – Dec 2016
- 93 pcnt of these Lupus patients supplemented with Vitamin D - Nov 2020
- Lupus patients are 5 X more likely to have low vitamin D – many meta-analyses
- Lupus fought by Vitamin D in all trials longer than 12 weeks - review Sept 2017
Autoimmune disease, mainly in 50 per 100,000 women, no cure, many parts of body Wikipedia
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