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Traumatic Brain Injury treated by Vitamin D - many studies

Vitamin D Protects against Traumatic Brain Injury via Modulating TLR4/MyD88/NF- κ B Pathway-Mediated Microglial Polarization and Neuroinflammation - July 2022

Biomed Res Int. 2022 Jul 15;2022:3363036. doi: 10.1155/2022/3363036. eCollection 2022.
Hongsheng Jiang 1, Xinyu Yang 2, Yanzhou Wang 1, Caifeng Zhou 1



Vitamin D (VD) deficiency is associated with neuroinflammation and neurocognitive deficits in patients with traumatic brain injury (TBI). The present study was aimed at investigating the therapeutic effects of VD and the molecular mechanisms after TBI. After the intraperitoneal injection of VD (1 µg/kg), sensorimotor and cognitive function was assessed via a series of behavioral tests in TBI rats. Traumatic outcomes were investigated by brain edema, blood-brain barrier (BBB) disruption, and morphologic staining. In vitro, cellular viability and cytotoxicity in primary hippocampal neurons were detected via the MTT method and LDH release. Hippocampal oxidative stress-related enzymes and proinflammatory mediators and the serum concentration of VD were analyzed by ELISA. The expression of VDR, TLR4, MyD88, and NF-κ B p65 was measured by Western blot. Furthermore, the levels of M1/M2 microglial markers were quantified using real-time PCR and Western blot. VD treatment significantly increased the serum level of VD and the hippocampal expression of VDR.

VD not only effectively alleviated neurocognitive deficits, brain edema, and BBB disruption but also promoted hippocampal neuronal survival in vivo and in vitro. Moreover, VD therapy prevented excessive neuroinflammation and oxidative stress caused by TBI. Mechanically, the hippocampal expression of TLR4, MyD88, and nuclear NF-κ B p65 was elevated in the TBI group but robustly restrained by VD treatment. Taken together, VD provides an important neuroprotection through modulating hippocampal microglial M2 polarization and neuroinflammation via the TLR4/MyD88/NF-κ B pathway.
 Download the PDF from VitaminDWiki

21+ VitaminDWiki pages with "Traumatic Brain Injury OR TBI" in the title

This list is automatcially updated

Items found: 21
Title Modified
Traumatic Brain Injury treated by Vitamin D - many studies 27 Sep, 2023
Concussions (traumatic brain injury) getting big press coverage, vitamin D might be both a cause and a solution 15 Jul, 2023
40% less likely to recover from TBI with Intracranial Injury if low vitamin D – June 2022 09 Jun, 2022
Traumatic Brain Injury recovered faster if high vitamin D (review of 58 studies) – April 2021 09 Jun, 2022
Vitamin D3 Attenuates Blood-Brain Barrier Disruption due to TBI (in rats) – Feb 2021 23 Feb, 2021
Traumatic Brain Injury – 120,000 IU of Vitamin D resulted in 3 fewer days on ventilators – RCT March 2020 17 Mar, 2020
Traumatic Brain Injuries treated by Vitamin D etc (US patent) – interview Dec 2019 25 Dec, 2019
Preventing and treating TBI with Vitamin D, Magnesium Omega-3, Zinc, etc – book 2011 21 May, 2019
Vitamin B12 treats Traumatic Brain Injury in mice – April 2019 21 May, 2019
Traumatic Brain Injuries routinely treated by Vitamin D, Omega-3, Progesterone and Gluatmine 15 May, 2019
Traumatic Brain Injury recovery helped by injection of 100,000 IU of Vitamin D – March 2019 13 May, 2019
Spinal cord problems more likely if TBI if little Omega-3 in diet – June 2013 07 Oct, 2018
Dementia risk increased 2.4 X following TBI, even if had not lost consciousness – May 2018 12 May, 2018
5 Traumatic brain injuries resulted in 2.8 X increased risk of dementia – April 2018 11 Apr, 2018
Mild Traumatic Brain Injury prevented with Omega-3, Resveratrol, etc (in rats) – Oct 2017 10 Oct, 2017
Mild Traumatic Brain Injury reduced by Vitamin D – May 2014 07 Aug, 2017
Cognitive decline after traumatic brain injury reduced by Omega-3 (mice) – Nov 2016 06 Dec, 2016
Traumatic brain injury treated by Vitamin D Progesterone Omega-3 and glutamine – May 2013 11 Sep, 2016
High-fructose diet slows recovery from brain injury - TBI, rats - Oct 2015 01 May, 2016
Traumatic Brain Injury in military - vitamin D - 2014 08 Feb, 2016
Vitamin D aided progesterone in reducing traumatic brain injury – RCT Dec 2012 03 Jan, 2015

TBI while in ICU: a single dose of 120,000 IU helped a lot - RCT March 2020

  • Neuroprotective Role of Oral Vitamin D Supplementation on Consciousness and Inflammatory Biomarkers in Determining Severity Outcome in Acute Traumatic Brain Injury Patients: A Double-Blind Randomized Clinical Trial

- https://doi.org/10.1007/s40261-020-00896-5  PDF
GCS = Glasgow outcome scale
GOSE = Glasgow Outcome Scale Extended

17,200 results for search of "Traumatic brain injury" ("Vitamin D" OR Omega-3)

Google Scholar Feb 2024

  • Omega-3 polyunsaturated fatty acids alleviate early brain injury after traumatic brain injury by inhibiting neuroinflammation and necroptosis - March 2023 https://doi.org/10.1515/tnsci-2022-0277 FREE PDF
  • Optimal vitamin D level ameliorates neurological outcome and quality of life after traumatic brain injury: a clinical perspective - Sep 2021 https://doi.org/10.1080/00207454.2021.1924706 Behind paywall
  • The More, the Better: High-Dose Omega-3 Fatty Acids Improve Behavioural and Molecular Outcomes in Preclinical Models in Mild Brain Injury - July 2021 https://doi.org/10.1007/s11910-021-01132-z FREE PDF
  • Chapter 10 - Vitamin D level and the outcome after traumatic brain injury - 2023 https://doi.org/10.1016/B978-0-323-89835-5.00009-0 PDF is behind a paywall
    • Paucity of vitamin D significantly affects the consequences of a brain injury. Deficiency of vitamin D along with traumatic brain injury (TBI) elevates the risk of severity of the injury. This possibly affects the therapeutic regimen prescribed for TBI which may have a negative effect on its outcome. Pre-clinical trials suggested that the levels of vitamin D influence the recovery and outcome after a TBI. Vitamin D deficiency has been found to cause more deterioration in patients with severe TBI than in the ones with mild TBI. This clearly validates the necessity of screening the levels of vitamin D in neural deficit in order to reduce the risk of morbidity, neurocognitive disorders, osteomalacia, and cardiovascular disease. This review focuses on the incidence of vitamin D deficiency in TBI and how it affects the recovery and subsequent quality of life of the patient.
  • The Effect of Omega-3 Fatty Acids on Recovery from Traumatic Brain Injury - Dec 2019 PHD Dissertation

VitaminDWiki founder has kept emergency vitamin D in all vehicles since 2017

333 items in – Trauma and surgery category:

Trauma and Surgery category has 333 articles

Large dose Vitamin D before surgery was found to help by 35 studies
Vitamin D is needed before most surgeries – many studies and RCTs
4.8 X more likely to die within 28 days of ICU if low Vitamin D - Jan 2024
Sepsis is both prevented and treated by Vitamin D - many studies
Thyroidectomy and Vitamin D - many studies
Orthopaedic surgeries need Vitamin D – many studies
Cancer - After diagnosis   chemotherapy
TBI OR "Traumatic Brain Injury - 21 in title as of Sept 2022
Superbug (Clostridium difficile) Infections strongly associated with low vitamin D - many studies
Glutamine and Omega-3 have also been proven to help several traumas/surgeries
   Note: Vitamin D also prevents the need for various surgeries and Omega-3 prevents many concussions/TBI
Trauma and Surgery is associated with 22 other VitaminDWiki categories
  Such as loading dose 33, Mortality 23, Infant-Child 21 Intervention 19 Cardiovascular 13, Injection 13 in Sept 2022

TBI ==> 7X more Substance Abuse in US soldiers - Aug 2023


  • "But the sharpest difference was the increase in substance use disorder among those with TBI, which rose 100% compared with a 14.5% increase in solders with no history of TBI."

The Standard Advice for Concussions Is Wrong (therapy does actually help) - Oct 2023

6 month to recover after falling off of a horse, The Atlantic

  • "The statistic of 3.8 million Americans a year gets bandied about, sometimes linked to mild head injuries from sports and other times to brain injuries of all kinds. Falls, recreational activities, car crashes, and domestic violence all can cause head trauma."
  • "Six months after falling off the horse, my final, lingering symptom—the feeling of pressure in my head when I’d been working for too long—went away. I recovered but was left wondering why it had taken so much time for me to be routed to the care that I needed. I’ll never know if I would have gotten better without it, but I suspect recovery would have, at the very least, taken much longer. Why had I—a patient with a brain injury—been the one sifting through scientific papers and online support groups rather than getting these referrals from my doctor? In our American health-care system, many patients are expected to be their own advocates, but in this case, when a better, clearer path to recovery is so well established, it seems like that should have been unnecessary."

$500,000 study to reduce use of Opioids for TBI Headache (igoring Vitamin D, etc.) Aug 2023

NFL & Players Association Award $500K to Investigators Studying Alternatives to Opioids for Post-Traumatic Headache TrialSiteNews

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Attached files

ID Name Comment Uploaded Size Downloads
19761 TBI RCT.jpg admin 07 Jul, 2023 53.93 Kb 256
19760 Vit D TBI RCT_CompressPdf.pdf admin 07 Jul, 2023 184.16 Kb 160
18182 how treat TBI_CompressPdf.pdf admin 25 Jul, 2022 509.39 Kb 264
18181 VDR TBI.jpg admin 25 Jul, 2022 32.92 Kb 496
18180 D drops aft TBI.jpg admin 25 Jul, 2022 38.84 Kb 620