Toggle Health Problems and D

Leprosy associated with changes to Vitamin D receptor genes (VDR)– April 2015

Association of Taq I, Fok I and Apa I polymorphisms in Vitamin D Receptor (VDR) gene with Leprosy.

Hum Immunol. 2015 Apr 15. pii: S0198-8859(15)00133-0. doi: 10.1016/j.humimm.2015.04.002. [Epub ahead of print]
Neela VS1, Suryadevara NC1, Shinde VG1, Pydi SS1, Jain S2, Singh SS3, Valluri VL1, Anandaraj MP1.

Vitamin D Receptor (VDR) is a transacting transcription factor which mediates immunomodulatory function and plays a key role in innate and adaptive immune responses through its ligand and polymorphisms in VDR gene may affect its regulatory function.

To investigate the association of three VDR gene polymorphisms (TaqI rs731236, FokI rs2228570 & ApaI rs7975232) with Leprosy.

The study group includes 404 participants of which 222 were leprosy patients (Paucibacillary=87, Multibacillary=135) and 182 healthy controls. Genotyping was done using PCR-RFLP technique. Statistical analysis was performed using SNP Stats & PLINK software.

The VDR FokI (rs2228570) ff genotype, ApaI (rs7975232) AA, Aa genotype and haplotype T-f-a, T-F-A were positively associated with leprosy when compared to healthy controls.

The two variants at Fok and Apa positions in VDR gene are significantly associated with leprosy. Genotypes at FokI (ff), ApaI (aa) and haplotype (T-F-a, T-f-a) may contribute to the risk of developing leprosy by altering VDR phenotype/levels subsequently modulation of immune response.

Copyright © 2015. Published by Elsevier Inc.
Publisher wants USD 36 for the PDF

PMID: 25890006