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Leprosy associated with changes to Vitamin D receptor genes (VDR)– April 2015

Association of Taq I, Fok I and Apa I polymorphisms in Vitamin D Receptor (VDR) gene with Leprosy.

Hum Immunol. 2015 Apr 15. pii: S0198-8859(15)00133-0. doi: 10.1016/j.humimm.2015.04.002. [Epub ahead of print]
Neela VS1, Suryadevara NC1, Shinde VG1, Pydi SS1, Jain S2, Singh SS3, Valluri VL1, Anandaraj MP1.


BACKGROUND:
Vitamin D Receptor (VDR) is a transacting transcription factor which mediates immunomodulatory function and plays a key role in innate and adaptive immune responses through its ligand and polymorphisms in VDR gene may affect its regulatory function.

OBJECTIVE:
To investigate the association of three VDR gene polymorphisms (TaqI rs731236, FokI rs2228570 & ApaI rs7975232) with Leprosy.

METHODS:
The study group includes 404 participants of which 222 were leprosy patients (Paucibacillary=87, Multibacillary=135) and 182 healthy controls. Genotyping was done using PCR-RFLP technique. Statistical analysis was performed using SNP Stats & PLINK software.

RESULTS:
The VDR FokI (rs2228570) ff genotype, ApaI (rs7975232) AA, Aa genotype and haplotype T-f-a, T-F-A were positively associated with leprosy when compared to healthy controls.

CONCLUSION:
The two variants at Fok and Apa positions in VDR gene are significantly associated with leprosy. Genotypes at FokI (ff), ApaI (aa) and haplotype (T-F-a, T-f-a) may contribute to the risk of developing leprosy by altering VDR phenotype/levels subsequently modulation of immune response.

Copyright © 2015. Published by Elsevier Inc.
Publisher wants USD 36 for the PDF

PMID: 25890006

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