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Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020

Altered decidual and placental catabolism of vitamin D may contribute to the aetiology of spontaneous miscarriage

Placenta, Volume 92, March 2020, Pages 1-8, https://doi.org/10.1016/j.placenta.2020.01.013


Items in both categories Pregnancy and Vitamin D Receptor:

Items in both categories Pregnancy and Vitamin D Binding Protein:

Items in both categories Pregnancy and other Vitamin D Genes:

Miscarriage in 29 VitaminDWiki titles as of Dec 2021

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  • Placental/decidual levels of vitamin D are decreased in spontaneous miscarriage.
  • CYP enzyme expression changes may be linked to hyperoxia.
  • VDR expression changes may be linked to infection.

Vitamin D catabolizing enzymes, along with vitamin D receptor (VDR) and vitamin D binding protein (DBP) are expressed in the decidua and placenta during pregnancy and capable of synthesizing active vitamin D. Vitamin D plays roles in immunoregulation and trophoblast invasion, key features of a successful pregnancy. Epidemiological data suggests that vitamin D deficiency is associated with both spontaneous and recurrent miscarriage but few studies have investigated the expression of the key vitamin D catabolizing enzymes in miscarriage.

Placenta and decidua were collected after termination of apparently normal pregnancies (controls, n = 22) or spontaneous miscarriage (n = 20). Immunohistochemical staining, Western Blot and qRT-PCR were performed for CYP27B1, CYP24A1, CYP2R1, VDR and DBP (not qRT-PCR). HTR-8/SVneo cells were cultured in CoCL2 (hypoxic mimetic) or LPS (bacterial infection mimetic) for 24 h, RNA extracted and qRT-PCR performed for CYP27B1, CYP24A1, CYP2R1 and VDR.

In spontaneous miscarriage, placental and decidual

  • expression of CYP27B1 was reduced, while
  • expression of CYP24A1, VDR and DBP was increased.

When a trophoblast cell line was treated with CoCL2 expression of CYP27B1 was increased and CYP24A1 was reduced, while LPS induced expression of VDR.

This is the first report of altered utero-placental vitamin D catabolism in spontaneous miscarriage. It is becoming accepted that women who are undergoing assisted reproductive technologies should ensure they have sufficient vitamin D levels prior to pregnancy, these data support that all women should ensure they are vitamin D replete before planning to get pregnant.

Created by admin. Last Modification: Friday December 24, 2021 20:02:40 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
13500 Decidua.jpg admin 15 Feb, 2020 12:52 21.22 Kb 383
13499 Placenta.jpg admin 15 Feb, 2020 12:51 24.66 Kb 344
13498 Placenta genes miscarriage.pdf PDF 2020 admin 15 Feb, 2020 12:43 1.49 Mb 312
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