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Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017

Association between the vitamin D receptor gene polymorphisms and diabetic nephropathy risk: a meta-analysis

Nephrologiy online: 13 July 2017, DOI: 10.1111/nep.13111
Fang Yin, Jing Liu, Ming-Xiu Fan, Xiao-Li Zhou, Xiao-Ling Zhang


Items in both categories Kidney and Vitamin D Receptor:

Items in both categories Diabetes and Vitamin D Receptor:

Items in both categories Diabetes and Kidney:

Vitamin D Receptor category has a summary table

Increased risk associated with a poor Vitamin D Receptor
   Note: Some diseases reduce VDR activation
those with a * are known to decrease activation

Health Problem
50Lyme Disease *
28Leprosy - another says 3X
15Chronic Heart Failure
15Temporary hair loss
14,7Childhood solid cancers
14Hand, Foot, and Mouth disease
12COVID Death
11Metabolic Syndrome
9.6Chronic Periodontitis
   and smoke
8Juvenile Rheumatoid Arthritis
7.6Crohn's disease
7.5Respiratory Tract Infections
5.8Low back pain in athletes
5 Respiratory Distress in preemies
5Ulcerative Colitis
5Coronary Artery Disease
5Asthma Child see also 1.3, 2.0 and 3.6
4.6Breast Cancer * 16.9 X another study
4.3Severe COVID in kids
4Polycystic ovary syndrome
3.6 Pneumonia - children
3.3 Pre-term birth
3.1 Colon Cancer survival
3 Multiple Sclerosis
3 Waist size
3 Ischemic Stroke
9X in women
3Gestational Diabetes
2.9Hand, Foot, Mouth Disease
2.8Osteoporosis & COPD
2.7Gastric Cancer
2.6Lupus in children
2.5 Lumbar Disc Degeneration
2.4Lung Cancer
2.2Juvenile idiopathic arthritis
2.1Adolescent idiopathic scoliosis in Asians
2Diabetic Retinopathy
2 Wheezing/Asthma see also 5X
2 Melanoma   Non-melanoma Skin Cancers
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.8Sleep Apnea
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.4Graves Disease
1.4 Rheumatoid arthritis
1.3Childhood asthma see also 5X
1.3Psoriasis in Caucasians
?? Rickets - Vitamin D resistant

Diabetic nephropathy (DN) is a severe microvascular complication frequently associated with type 1 and type 2 diabetes mellitus. The objective of this study was to estimate the effect between Apa I, Bsm I, Fok I and Taq I polymorphisms of the vitamin D receptor (VDR) gene and DN susceptibility.

Eligible case–control studies published updated to March 2017 were searched. The odds ratio (OR) and 95% confident intervals (CI) were employed to calculate the strength of effect.

12 articles were finally screened out, including 3954 diabetic patients and 1248 healthy controls. When compared with the diabetic patients without nephropathy, our results found that only the Bsm I polymorphism was associated with increased risk of DN under the

  • allelic model (B vs. b: OR = 1.51, 95% CI = 1.03-2.20, P = 0.04) and
  • dominant model (BB + Bb vs. bb: OR = 1.52, 95% CI = 1.00-2.31, P = 0.05).

When compared with the healthy controls, our results showed that the Bsm I polymorphism was associated with the DN susceptibility under the

  • allelic model (B vs. b: OR = 1.80, 95% CI = 1.12-2.91, P = 0.02), the
  • homogeneous model (BB vs. bb: OR = 1.43, 95% CI = 1.03-1.98, P = 0.03), and the
  • domain model (BB + Bb vs. bb: OR = 1.80, 95% CI = 1.06-3.05, P = 0.03);

the Taq I variant was associated with increased risk of DN only under the heterogeneous model (Tt vs. tt: OR = 2.29, 95% CI = 1.04-5.03, P = 0.04).

Our results suggested that B allele, and BB + Bb genotypes of Bsm I variant, Tt genotype of Taq I variant might be risk factors for DN. Future researches are still needed to identify our results.

Created by admin. Last Modification: Tuesday June 11, 2019 16:13:28 GMT-0000 by admin. (Version 5)