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Diabetic foot ulcer 1.7 times more likely if poor Vitamin D Receptor – Jan 2017

Vitamin D receptor gene FokI variant in diabetic foot ulcer and its relation with oxidative stress

Gene, Vol599, 30 Jan 2017, Pages 87–91 http://dx.doi.org/10.1016/j.gene.2016.11.012
Negin Sorousha, Mania Radfara, b, , radfarma at tums.ac.ir, Armita Kakavand Hamidic, Mohammad Abdollahid, Mostafa Qorbanie, Farideh Razif, Ensieh Nasli Esfahanif, Mahsa M Amolic, ,

See also VitaminDWiki

Vitamin D Receptor category has the following

464 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 44 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor.Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (17 studies), Breast Cancer (20 studies), Colon Cancer (13 studies), Cardiovascular (22 studies), Cognition (16 studies), Diabetes (22 studies), Hypertension (6 studies), Infant (18 studies), Lupus (6 studies), Metabolic Syndrome (3 studies), Mortality (4 studies), Multiple Sclerosis (11 studies), Obesity (15 studies), Pregnancy (22 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (30 studies),   Click here for details
Some health problems, such as Breast Cancer and Diabetes, protect themselves by reducing VDR activation
Suspect that SAR-COV-2 also protects itself from Vitamin D

55 health problems associated with poor VDR


A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 45 diseases at least double with poor VDR as of Nov 2022  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR


How to increase VDR activation


Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14)Butyrate especially gutVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Items in both categories Diabetes and Vitamin D Receptor are listed here:

Note: Perhaps Diabetes, like Breast Cancer etc, has learned to protect itself by reducing the activation of the Vitamin D Receptor


A diabetic foot severity grade from the web

Image

Publisher wants $36 for the PDF

Highlights

  • Association of VDR rs2228570 T allele with DFU in Iranian patients with T2DM is found
  • T allele is more frequent in patients with severe DFU based on Wagner classification
  • Hyperglycemia causes generation of free radicals which leads to oxidative stress (OS)
  • FokI variant correlation with TBARS level was found in patients carrying T allele


Purpose
The patient's suffering and financial costs affiliated with Diabetic Foot Ulcer (DFU), as one of the most important complications of diabetes, are highly undesirable and this highlights the importance of preventive medicine about this disorder. Furthermore hyperglycemia causes generation of free radicals which leads to oxidative stress (OS). Hence, this study aims to examine the association between vitamin D receptor (VDR) gene FokI polymorphism and DFU in Iranian population and also its correlation with OS biomarkers.

Materials and methods
In a case-control study, a total of 212 patients with type 2 diabetes with and without diabetic foot ulcer were included. Genotyping was conducted by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Samples were analyzed for thiobarbituric reactive substances (TBARS) and ferric reducing ability of plasma (FRAP) as markers of OS.

Results
The results indicated a significant difference in genotype frequencies of VDR gene FokI polymorphism in patients with diabetic foot ulcer in comparison to those without diabetic foot ulcer (TT + TC vs. CC p = 0.04; OR = 1.76; 95% CI = 1.02–3.05). Moreover, the patients carrying the T allele had a significantly higher level of TBARS (p = 0.01).

Conclusions
We found a significant association between FokI functional variant of VDR gene and diabetic foot ulcer in an Iranian population. Increased levels of TBARS in patients carrying the T allele of FokI polymorphism indicate an association between this variant and OS in patients with diabetes.

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