Table of contents
The VDR gene confers a genetic predisposition to Graves' disease and Graves' ophthalmopathy in the Southwest Chinese Han population
Gene. 2021 May 30;145750. doi: 10.1016/j.gene.2021.145750
Fangyu Zhou 1, Zhongzhi Liang 2, Xin Wang 1, Guiqin Tan 1, Wenwen Wei 1, Guangbing Zheng 1, Xiaomin Ma 1, Dan Tian 1, Hua Li 3, Hongsong Yu 4
Objective: Graves' disease (GD) is a common autoimmune disease manifesting with diffuse symmetric thyroid gland enlargement, pretibial myxedema, and Graves' ophthalmopathy (GO). Recently, the vitamin D receptor (VDR) gene has been linked to various autoimmune diseases. This study aimed to investigate the association of VDR gene polymorphisms with susceptibility to GD and GO in the Southwest Chinese Han population.
Methods: A two-stage association study was performed in 1,209 controls and 650 GD patients by PCR-RFLP assay. Real-time PCR and ELISA were carried out to quantify gene expression and cytokine production.
Results: The first-stage study showed that the frequency of VDR/Apa I AA genotype was significantly increased in GD (Pc = 1.67×10-2, OR = 1.98). The second-stage and combined studies confirmed the association of VDR/Apa I with GD (AA genotype: Pc = 3.45×10-4, OR = 1.87; A allele: Pc = 2.62×10-2, OR = 1.20). The stratification analysis showed that GO patients had a higher frequency of the VDR/Apa I AA genotype (Pc = 8.69×10-5, OR = 2.84). Functional experiments showed a decreased VDR expression and TGF-β1 production as well as an increased IL-17 production in VDR/Apa I AA genotype carriers.
Conclusion: The VDR/Apa I polymorphism is significantly associated with GD and GO, and it may be involved in the development of GD and GO by influencing VDR mRNA expression levels and the secretion levels of cytokines.
VitaminDwiki - Autoimmune category contains
206 items in Autoimmune category - Vitamin D and MS Asthma RA Diabetes Gut Allergy Hay Fever Lupus Psoriasis
- Predicted 95% autoimmune cured by HIGH-DOSE vitamin D - 2014
- 10% of the UK have Autoimmune Diseases - Lancet May 2023 PDF is behind a paywall
- Increase in 20 years : coeliac disease 2.19 X. Sjogren's syndrome 2.09, and Graves' disease 2.07
- All 43 references are FREE on-line
- Autoimmune diseases fought by Vitamin D, especially if have more than 40 ng – Sept 2022
- The BEST Nutrient for Autoimmune Conditions (Vitamin D) - video May 2022
- The number 1 Deficiency behind All Autoimmune Diseases (Vitamin D) video - Dec 2023
- Autoimmune disease clusters run in families having low D
- How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
- 120 doctors and 20,000 MS patients using high dose Vitamin D Dec 2018
- Vitamin D has treated Multiple Sclerosis and autoimmune diseases for 16 years – Coimbra April 2018
- Vitamin D Receptor is associated in over 58 autoimmune studies
- More autoimmune disease if higher pollution or lower UVB - Feb 2023
- Many autoimmune diseases associated with low vitamin D or poor Vit D genes – July 2019
See also web: consensus that ~50 diseases are autoimmune, ~50 more are suspected:
Vitamin D Recetor restricts how much Vit D gets to the cells
Vitamin D Receptor is associated in over 40 autoimmune studies
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators
Vitamin D titles containing "Graves" (7 as of Aug 2022)
Items found: 7Graves' disease 2X more likely if poor Vitamin D Receptor (like many other autoimmune diseases) – May 2021(Cached) Printer Friendly Follow this page for updates9394 visitors, last modified 19 Aug, 2022, This page is in the following categories (# of items in each category)