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Severe hand, foot, and mouth virus is 2.9 X more likely if poor Vitamin D receptor – Oct 2018

Association of polymorphisms in the vitamin D receptor gene with severity of hand, foot, and mouth disease caused by enterovirus 71

Journal of Medical Virology, https://doi.org/10.1002/jmv.25349
Ya‐Ping Li Hui‐Ling Deng Li‐Hong Xu Mu‐Qi Wang Mei Li Xin Zhang Shuang‐Suo Dang


HFMD rarely fatal, but is increasing

Vitamin D Receptor category has the following

438 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 43 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor.Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (17 studies), Breast Cancer (19 studies), Colon Cancer (11 studies), Cardiovascular (20 studies), Cognition (15 studies), Diabetes (21 studies), Hypertension (4 studies), Infant (16 studies), Lupus (6 studies), Metabolic Syndrome (3 studies), Mortality (4 studies), Multiple Sclerosis (11 studies), Obesity (15 studies), Pregnancy (21 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (26 studies),   Click here for details
Some health problems, such as Breast Cancer and Diabetes, protect themselves by reducing VDR activation
Suspect that SAR-COV-2 also protects itself from Vitamin D

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A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 44 diseases at least double with poor VDR as of Oct 2019  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells
13) Sulfroaphane and perhaps sulfurVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR


Severe hand, foot, and mouth disease (HFMD) is sometimes associated with critical complications that can cause substantial child mortality. Activity of the vitamin D receptor (VDR) may influence the outcomes of enterovirus 71 (EV71) infection. This case‐control study aimed to assess the association of single‐nucleotide polymorphisms (SNPs) in the gene encoding the VDR with the severity of EV71‐associated HFMD. We selected four VDR SNPs based on linkage disequilibrium and functional prediction, and we tested them using the SNPscan multiple SNP typing method for potential association with severity of EV71‐associated HFMD.

We found a significant association in the case of

  • rs11574129 (G vs A: odds ratio (OR), 0.3439; 95% confidence intervals (CI), 0.1778‐0.6653) and
  • rs739837 (T vs G: OR, 0.5580; 95%CI, 0.3352‐0.9291).

Our results suggest that these two SNPs may influence the severity of EV71‐associated HFMD.

Created by admin. Last Modification: Friday November 23, 2018 12:04:46 GMT-0000 by admin. (Version 7)

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