Variety of evidence that Vitamin D helps the brain – July 2014

Vitamin D as a Neurosteroid Affecting the Developing and Adult Brain

Annual Review of Nutrition, Vol. 34:117-141 - July 2014, DOI: 10.1146/annurev-nutr-071813-105557
Natalie J. Groves,1 John J. McGrath,1,2,3 and Thomas H.J. Burne1,2,  t.burne at uq.edu.au

 Download the PDF from Sci-Hub via VitaminDWiki

Vitamin D deficiency is prevalent throughout the world, and growing evidence supports a requirement for optimal vitamin D levels for the healthy developing and adult brain. Vitamin D has important roles in proliferation and differentiation, calcium signaling within the brain, and neurotrophic and neuroprotective actions; it may also alter neurotransmission and synaptic plasticity. Recent experimental studies highlight the impact that vitamin D deficiency has on brain function in health and disease. In addition, results from recent animal studies suggest that vitamin D deficiency during adulthood may exacerbate underlying brain disorders and/or worsen recovery from brain stressors. An increasing number of epidemiological studies indicate that vitamin D deficiency is associated with a wide range of neuropsychiatric disorders and neurodegenerative diseases. Vitamin D supplementation is readily available and affordable, and this review highlights the need for further research.

Sections include
INTRODUCTION
THE ACTIONS OF VITAMIN D WITHIN THE BRAIN
RODENT MODELS OF VITAMIN D DEFICIENCY
LINKS WITH NEUROPSYCHIATRIC AND NEURODEGENERATIVE DISORDERS
FUTURE DIRECTIONS
CONCLUSION

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• The Synaptic and Circuit Functions of Vitamin D in Neurodevelopment Disorders Feb 2023 https://doi.org/10.2147/NDT.S407731 FREE PDF
• Maternal vitamin D deficiency and brain functions: a never-ending story - 2023 10.1039/D3FO00166K - FREE PDF
• Vitamin D and the brain: Genomic and non-genomic actions - Sept 2017, https://doi.org/10.1016/j.mce.2017.05.035
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• Vitamin D and brain health: the need for vitamin D supplementation and sensible sun exposure- Holick Sept 2014 has the following chart

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VitaminDWiki pages with BRAIN in title (94 as of Oct 2022)

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