Vitamin D Receptor Gene Polymorphism and susceptibility to Asthma: meta-analysis based on 17 case–control studies
Annals of Allergy, Asthma & Immunology https://doi.org/10.1016/j.anai.2019.10.014
Masoud Hassanzadeh Makoui PhD1 DanialImani PhD1 Morteza Motallebnezhad PhD234 MaryamAzimiPhD56 BahmanRazi PhD7
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
It would appear that this study has grossly underestimated the association of Asthma and VDR
Currently unable to access the PDF to understand why
Overview Asthma and Vitamin D contains
- Atopies (allergy, asthma, rhinitis, etc.) variously associated with low Vitamin D and poor Vitamin D Receptor – Aug 2021
- Poor response to Asthma inhaler if poor Vitamin D Receptor – Dec 2019
- Asthma 3.7X higher risk of poor Vitamin D Receptor (teens in Taiwan in this case) – Nov 2019
- Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis Oct 2019
- Asthmatic children 5X more likely to have a poor Vitamin D Receptor – June 2019
- Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016
- 2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015
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During the last decade, several studies have evaluated the potential association between vitamin D receptor (VDR) gene polymorphism and susceptibility to asthma. In spite of valuable finding, the results are still contradictory. Therefore, a comprehensive meta-analysis not only solves discrepancies but provides a clue for future projects.
This meta-analysis was performed to identify whether VDR gene polymorphisms (FokI (rs2228570) or / and TaqI (rs731236) or / and BsmI (rs1544410) or / and ApaI (rs7975232)) play role in the risk of asthma.
The electronic search of web of science, Scopus, and PubMed databases were systematically conducted from their inception until Jun 2019, to identify all published studies. Eligibility of studies was confirmed by precise inclusion and exclusion criteria and the resultant studies were analyzed.
A total of 17 studies concerning to VDR gene polymorphisms and asthma risk were included in this meta-analysis. The results of pooled analysis revealed a statistical significant association between FokI SNP [
- dominant model (OR= 0.78, 95% CI, 0.62-0.98,
- random effect model) and allelic model (OR= 0.81, 95% CI, 0.67-0.98, random effect model)]
- and TaqI SNP [homozygote contract model (OR= 0.70, 95% CI, 0.54 - 0.89)]
with asthma risk. Moreover, subgroup analysis showed that ethnicity influences asthma risk in Asian, African and American populations.
The sensitivity analyses confirmed the stability of the results.
This meta-analysis suggests that VDR gene polymorphism is associated with the risk of asthma.