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Leprosy 28 X more likely if a newly found Vitamin D Receptor modification (A61894G) – Dec 2017


Vitamin D is treating and preventing Leprosy in Myanmar


A novel vitamin D receptor polymorphism associated with leprosy - Dec 2017

Journal of Dermatological Science, online 23 December 2017 https://doi.org/10.1016/j.jdermsci.2017.12.007

Highlights from PDF
 A new polymorphism, A61894G, in VDR gene was associated to leprosy
 The transversion (G>A) conferred susceptibility for disease in PB group
 T61968C and A61894G polymorphisms interaction are crucial in M. leprae infection
 TCAA genotype and negative Mitsuda presented 28.33-fold chance to develop the leprosy
 Download the PDF from Sci-Hub via VitaminDWiki

Chance of leprosy occurrence (odds ratio) by association of VDR gene polymorphisms and Mitsuda test results in patients and household contacts
Image
Leprosy appears to also be related to many of the other VDR gene polymorphisms


Leprosy 3X more likely if poor VDR – Nov 2018

VDR polymorphism, gene expression and vitamin D levels in leprosy patients from North Indian population
PLOS x, Nov 27, 2018 https://doi.org/10.1371/journal.pntd.0006823
Itu Singh , Mallika Lavania, Vinay Kumar Pathak , Madhvi Ahuja , Ravindra P. Turankar, Vikram Singh, Utpal Sengupta

Background
Leprosy is a chronic infectious disease caused by Mycobacterium leprae and mainly affects skin, peripheral nerves. Vitamin D receptor (VDR) gene polymorphism has been found to be associated with leprosy. Vitamin D has been shown to control several host immunomodulating properties through VDR gene. Vitamin D deficiency was also found to be linked to an increased risk for several infections and metabolic diseases.

Objective
In the present study, we investigated the association of VDR gene polymorphism, mRNA gene expression of VDR and the vitamin D levels with leprosy and its reactional states.

Methodology
A total of 305 leprosy patients consisting of tuberculoid (TT), borderline tuberculoid (BT), borderline lepromatous (BL), lepromatous leprosy (LL), as well as 200 healthy controls were enrolled in the study. We identified single nucleotide polymorphisms (SNPs) of VDR Taq1, Fok1 and Apa1, as well as the expression of VDR mRNA gene using PCR-based restriction fragment length polymorphism (RFLP) analysis and real-time PCR respectively. We also performed ELISA to measure vitamin D levels.

Result
We observed that SNP of VDR gene (Fok1 and Taq1) are associated with the leprosy disease. The allelic frequency distribution of T and t allele (p = 0.0037), F and f allele (p = 0.0024) was significantly higher in leprosy patients and healthy controls. ff genotype of Fok1 was found to be associated with leprosy patients [p = 0.0004; OR (95% CI) 3.148 (1.662–5.965)]. The recessive model of Fok1 genotype was also found to be significantly associated in leprosy patients in comparison to healthy controls [p = 0.00004; OR (95% CI) 2.85 (1.56–5.22)]. Leprosy patients are significantly associated with t-F-a haplotype. Further, VDR gene expression was found to be lower in non-reaction group compared to that of reaction group of leprosy and healthy controls. Paradoxically, we noted no difference in the levels of vitamin D between leprosy patients and healthy controls.

Conclusion
Blood levels of vitamin D do not play any role in clinical manifestations of any forms of leprosy. ff genotype of Fok1 and tt genotype of Taq1 was found to be associated with leprosy per se. Association of t-F-a haplotype with leprosy was found to be significant and could be used as a genetic marker to identify individuals at high risk for developing leprosy. VDR gene expression was lower in TT/BT and BL/LL groups of leprosy in comparison to that of healthy controls.

Author summary
Present study was carried out to find out the association of vitamin D receptor (VDR) gene polymorphism, mRNA gene expression of VDR gene and level of vitamin D with leprosy reactions and leprosy patients. Surprisingly, level of vitamin D in leprosy patients was not found to be associated with the disease and its manifestations. VDR genotypes (Fok1 and Taq1) were found to be associated with leprosy patients. t-F-a haplotype was significantly associated with leprosy patients. Gene expression of vitamin D receptor was lower in leprosy patients in comparison to healthy controls.


Higher VDR, much less Leprosy - March 2019

Correlation of Serum Vitamin D Receptor Level with Bacterial Index in Multibacillary Leprosy Patients at Sanglah General Hospital, Bali-Indonesia

  • "For the correlation of plasma VDR level and the bacterial index, using Spearman correlation, there was strong negative correlation between plasma VDR level and bacterial index (r = – 0.954; p < 0.001)."

Some PubMed studies of Leprosy, genes, and Vitamin D Receptor

 Evaluation of the economic burden of leprosy among migrant and resident patients in Guangdong Province, China - 2017
 Gene Association with Leprosy: A Review of Published Data - 2016
 VDR polymorphism, gene expression and vitamin D levels in leprosy patients from North Indian population - 2018
 Vitamin D receptor expression levels determine the severity and complexity of disease progression among leprosy reaction patients - 2015
 Vitamin D receptor expression ... severity of leprosy: a systematic review - 2017
 Leprosy difficult to diagnose and treat -Vit D and VDR mentioned - 2018


See also web - Leprosy (nothing about Vitamin D nor VDR)

  • "Adverse reactions in leprosy patients who underwent dapsone multidrug therapy: a retrospective study" 2017
  • What Is Leprosy? Embrace a Village - extensive information, Their FACT section follows
    Leprosy is also called Hansen’s disease, named after Dr. Gerhard-Henrik Armauer Hansen of Norway, the first to identify M. leprae as the bacteria that causes leprosy.
    Leprosy is only mildly contagious. Most people—approximately 95% of us—have a natural immunity to leprosy.
    Leprosy is curable with multidrug therapy (MDT). Soon after beginning MDT, patients are no longer considered contagious.
    Approximately 200,000 new cases of leprosy are reported each year.
       50% to 66% of all new cases occur in India.
    Approximately 150 people are diagnosed with leprosy in the United States each year.
    Other than humans, armadillos are the only other animal know to host the leprosy bacillus.
    Because of the stigma associated with the disease, many do not seek treatment until the disease has progressed. It is estimated that 2 million people worldwide suffer disabilities resulting from leprosy.
    Contrary to popular belief, leprosy does not cause limbs and digits to “fall off” of the body. Instead, repeated injury and infection—as a result of loss of sensation—leads to the shortening of fingers, toes, and limbs as tissue is absorbed into the body.
  • Leprosy Wikipedia
    infection by the bacterium Mycobacterium leprae or Mycobacterium lepromatosis.
    " Most new cases occur in 16 countries, with India accounting for more than half."
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Created by admin. Last Modification: Friday July 12, 2019 02:28:00 GMT-0000 by admin. (Version 33)

Attached files

ID Name Comment Uploaded Size Downloads
12291 Adverse reactions in leprosy.pdf admin 10 Jul, 2019 09:06 119.29 Kb 19
12206 Leprosy difficult to dianose and treat (Vit D mentioned) - 2018.pdf PDF 2018 admin 26 Jun, 2019 17:54 470.15 Kb 24
12170 Leprosy VDR Sci-Hub.pdf admin 20 Jun, 2019 15:16 507.44 Kb 34
12090 Epid Leprosy Wikipedia.jpg admin 07 Jun, 2019 10:07 36.05 Kb 24
12089 Lep info 1.jpg admin 06 Jun, 2019 17:11 63.62 Kb 85
12076 VDR and leprosy problems.pdf admin 05 Jun, 2019 19:29 728.83 Kb 41
12075 VDR Leprosy India 2018.pdf admin 05 Jun, 2019 19:29 988.80 Kb 37
12074 Gene Association with Leprosy 2016.pdf admin 05 Jun, 2019 19:28 1.10 Mb 41
12073 Leprosy China.pdf admin 05 Jun, 2019 19:28 422.03 Kb 37
10925 VDR Leprosy Nov 2018.pdf PDF 2018 admin 27 Nov, 2018 21:50 2.31 Mb 28
9013 WHO leprosy 2016.jpg admin 24 Dec, 2017 17:45 49.80 Kb 430
9010 VDR Leprosy.jpg admin 24 Dec, 2017 16:19 40.75 Kb 299
9009 VDR leprosy.pdf PDF 2017 admin 24 Dec, 2017 13:35 176.02 Kb 201
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