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Vitamin D Binding Protein

136 items in Vitamin D Binding Protein category

See also Vitamin D Receptor Genetics CYP27B1

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Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,

GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
The actual D getting to the cells is a function of measured D and all 4 genes
There is >2X increase in 8+ health problems if have poor VDBP (GC)
It appears that VDBP only blocks oral vitamin D, but not Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral UV

Search VitaminDWiki for GC OR VDBP 3,800 items as of May 2019
Did not search for "Vitamin D Binding Protein" as that phrase is on virtually every page in VitaminDWiki

Increased Risk	Health Problem
11 X	Preeclampsia
6 X	Food Allergy
5 X	PTSD
4 X, 5X	Kidney Cancer
4 X	Poor Response to Oral Vitamin D
3 X	Ear infection
2 X	MS
2 X	Colorectal Cancer
2 X	Prostate Cancer -in those with dark skins
1.3 X	Infertility

VDBP is NOT directly detected by vitamin D blood tests

MS and Vitamin D Binding Protein:

TB and Vitamin D Binding Protein:

Breathing and Vitamin D Binding Protein:

Infant-Child and Vitamin D Binding Protein:

Pregnancy and Vitamin D Binding Protein:

wiki page:

See also web

Meta-analysis of vitamin D-binding protein and cancer risk Sept 2015
"Results: We found a borderline decrease in cancer risk for subjects with high compared to low levels of DBP"
"We included 28 independent studies concerning: basal cell carcinoma, bladder, breast, colon-rectum, endometrium, liver, esophagus, stomach, melanoma, pancreas, prostate and kidney. "

Vitamin D Binding Protein

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Links to this page 48
- 10 reasons for poor response to Vitamin D (race, binding protein, etc.) – Nov 2017 2 X better survival of digestive cancer if 2,000 IU of Vitamin D plus good VDBP gene – RCT Feb 2020 A poor Vitamin D Binding protein can confirm various clinical diagnoses - Dec 2019 A woman who has ZERO Vitamin D in her blood, even with supplementation – March 2019 Acute rheumatic fever associated with lower vitamin D – July 2017 Adaptive and innate immune system, vitamin D genes, and Rheumatoid Arthritis – June 2019 Asthma more closely associated with poor VDBP gene than with poor Vitamin D level – June 2014 Benefits of Vitamin D often limited by genes Bio-available Vitamin D is reduced by half during pregnancy – Jan 2017 COPD in Asians twice as likely if poor Vitamin D Binding Protein – meta-analysis May 2019 COVID-19 is strongly associated with low vitamin D CYP27B1 DBP-L is 8 times higher with Bipolar Disorder, but might be invisible to most tests – April 2017 Decreased response to vitamin D in white children having poor Vitamin D binding gene – Feb 2019 Drug hypersensitivity is associated with Vitamin D Binding Protein, etc. – June 2019 Ear infections in children 3X more likely if poor vitamin D binding protein – July 2018 Food allergies are associated with Vitamin D thru genes, etc. – March 2018 Free vitamin D level much higher in Asians vs Caucasians after 150,000 IU dose – Aug 2018 Genetics Growth Hormone problem (Acromegaly) more likely if vitamin D gene problems Health Problems and D How should Vitamin D be tested – a changing landscape – June 2016 Hypothesis: Vitamin D Binding Protein limits vitamin D benefits outside of kidney too– Oct 2013 Increased risk of various cancers if poor vitamin D genes (Binding Protein and CYP27B1) - Sept 2019 Kidney Cancer 4X more likely if poor Vitamin D Binding Protein (5X in previous study) – Oct 2019 Kidney failure 1.7X more likely - Vitamin D Binding Protein – Feb 2016 Major depression associated with vitamin D Binding Protein in youths – March 2018 Many reasons why vitamin D deficiency has become epidemic MS prevention by UV is 2X better than prevention by vitamin D levels – Jan 2012 Poor Vitamin D response 4X more likely if poor Vitamin D binding proteins - July 2019 Posttraumatic stress disorder 5X more likely if both low vitamin D and poor gene (VDBP) – Sept 2019 Preeclampsia 11X more likely if poor Vitamin D Binding Protein (South Africa) - Sept 2019 Prostate cancer 3X more likely to be lethal if both low vitamin D and poor Vitamin D Binding gene – March 2020 Reasons for low response to vitamin D Response to Vitamin D varies with Vitamin D Binding Protein gene – RCT May 2018 Rheumatoid Arthritis synovial fluid has lower levels Vitamin D binding protein, 3-epi – Jan 2019 The genetics of vitamin D – Oct 2018 Topical Vitamin D provides more benefits than oral for some people Twice as likely to survive Colorectal Cancer if had good level of Vitamin D Binding Protein – July 2019 U.S. healthcare system (and its investors) are really good at monetizing illness, but not wellness – May 2019 Ulcerative Colitis (new) associated with lower free and bioavailable Vitamin D, but not total – Feb 2019 Vitamin D Binding Protein and Coronary artery disease – Oct 2017 Vitamin D Binding Protein masks how much Vitamin D gets to tissues – May 2019 Vitamin D Binding Protein Review - Oct 2019 Vitamin D is more bio-available when children are critically ill (less Binding Protein) – Sept 2015 Vitamin D may be a magic bullet for the cells (not based on Vitamin D blood tests) – Jan 2020 Vitamin D Receptor summary Vitamin D stored in muscle via Vitamin D Binding Protein – July 2019

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