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Uterine Fibroids (uterine leiomyoma, need hysterectomy) 1.9 more likely if a Vitamin D receptor problem – Sept 2015

Egyptian Journal of Medical Human Genetics, doi:10.1016/j.ejmhg.2015.08.007
Shirin Shahbazi,

Evidences are growing toward an inhibitory role of vitamin D3 in uterine leiomyoma pathogenesis. Uterine leiomyoma commonly affects women of reproductive age and is referred to as one of the most common indications for hysterectomy, worldwide. The effects of vitamin D are mediated through the vitamin D receptor. A single nucleotide polymorphism of the VDR gene results in longer protein with decreased activity. The present study has focused on the distribution of FokI polymorphism in Iranian patients with uterine leiomyoma. Using the PCR-RFLP method 45 cases and 53 controls were assessed. The results demonstrated a correlation between VDR TT genotype and uterine leiomyoma by Odds Ratio of 1.886 (CI, .767–4.640). The examination of heterozygous CT genotype also showed the same result by Odds Ratio of 1.875 (CI, .629–5.590).
This study lends support for an increased risk of uterine leiomyoma associated with the VDR rs2228570 polymorphism. To the best of our knowledge this is the first report regarding VDR FokI polymorphism in leiomyoma patients.
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For those with gene problems, generally just need more vitamin D

See also VitaminDWiki

Vitamin D Receptor category has the following

303 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population has a poor VDR (40% of the Obese )

A poor VDR increases the risk of 53 health problems  click here for details
The risk of 41 diseases at least double with poor Vitamin D Receptor as of July 2019

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR

Attached files

ID Name Comment Uploaded Size Downloads
5910 Uterine fibroids.jpg admin 12 Sep, 2015 20:56 27.59 Kb 6359
5909 VDR hysterectomy.pdf PDF 2015 admin 12 Sep, 2015 20:56 640.12 Kb 591
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