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Overview Kidney and vitamin D

  • FACT: Kidney is the primary way to activate vitamin D
  • FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
  • FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
  • FACT: There are many on-going intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
  • FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
  • FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
  • Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
      Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
    Calcitriol - which bypasses the need for the kidney to activate vitamin D
      Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
        Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012
  • Category Kidney and Vitamin D contains 194 items

See also VitaminDWiki

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See also web

  • Vitamin D/VDR in acute kidney injury: a potential therapeutic target - Nov 2020 -doi: 10.2174/0929867327666201118155625
  • Clinical Trials kidney and Vitamin D INTERVENTION 182 trials as of Nov 2020
  • Clinical Trials (kidney OR dialysis) AND "vitamin d" 576 studies Nov 2020
    • "There is not enough evidence showing that one type of active vitamin D is better than another, but there is much difference between their costs." More studies needed
  • Editorial over the Many Faces of Vitamin D in Chronic Kidney Disease: from Mineral to Immune-Inflammatory Modulator - Nov 2017
    "Taken together, the findings of Zhao et al. confirm the immune-inflammatory modulating capacity of vit D and expand the molecular basis to further explore its therapeutic potential in CKD"
     Download the PDF from VitaminDWiki__
  • Preserved circannual rhythm of vitamin D in kidney transplant patients. Sept 2012
    Incredibly Kidney transplant patients are advised to avoid sun exposure because of their high risk of skin cancer.
  • Arrhythmias in chronic kidney disease 2011
    "The arrhythmia burden of the patient with CKD is high, with the single greatest contributor to mortality in end stage renal disease (ESRD) being sudden cardiac death (SCD)"
  • Magnesium – its role in CKD. Nefrologia, May 2013, full text online
    Magnesium for treatment of hyperphosphataemia in patients with chronic kidney disease
  • Dialysis Takes a Toll Dec 2013 New York Times
    Huge health problems with dialysis. No mention of vitamin D
    References a RCT of Dialysis. More of the group which which was randomly assigned to delayed dialysis (7 months) survived
  • Vitamin D supplementation and mortality risk in chronic kidney disease: a meta-analysis of 20 observational studies. PDF at bottom of this page
    Compares different types of vitamin D - no analysis of Magnesium, etc.
  • Treatment Failure of Active Vitamin D Therapy in Chronic Kidney Disease: Predictive Factors Sept 2015
    ". . . up to 50% of patients may experience treatment failure eventually because of development of hypercalcemia or resistant SHPT, characterized by an elevated intact PTH (iPTH) level despite treatment"
    "We propose a definition of vitamin D treatment failure as iPTH >600 pg/ml after 6 months of intravenous active vitamin D treatment and corrected total calcium serum levels >10.2 mg/dl,. .
  • Patient Voices: Kidney Disease New York Times Jan 2018
    Affecting nearly 30 million in the United States
    " chronic kidney disease can be caused by diabetes, chronic hypertension, a genetic factor or a rare disease"
  • Vitamin D treatment and mortality in chronic kidney disease: a systematic review and meta-analysis. 2013 PDF at bottom of this page
    14 studies, 195,000 patients, Risk of death reduced 49% if had gotten ANY AMOUNT of ANY KIND of vitamin supplementation
    Imagine how many fewer deaths if had gotten the right amount of the right kind of vitamin D, along with Magnesium

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Kidney is one of only 2 ways that vitamin D is activated in the body

A guess (based on NO data) 40% of vitamin D is activated by the kidneys

Vitamin D Deficiency Vicious circles a portion of the chart follows

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Low vitamin D ==> Diabetes ==> Kidney failure
Kidney failure ==> Low Vitamin D and poor regulation of Magnesium
Activated vitamin D decreases with worsening of CKD
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Incidence of Chronic Kidney Disease - US

Perhaps 120% increase incidence in a decade
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Dark skinned people (with less vitamin D) have 3X more incidence of CKD
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http://vitamindwiki.com/tiki-index.php?page_id=5644
Click on chart for more information


Causes of CKD

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only 15% kidney function remains by stage 5

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CKD signs and symptoms

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Factoids from The Body by Bill Bryson, 2019

  • It remains something of a mystery even now as to why we have two kidneys.
  • The kidneys process about 190 quarts of water and 3.3 pounds of salt. daily
  • Between the ages of forty and seventy, kidney filtration capacity drops by about 50 percent.
Overview Kidney and vitamin D        
50474 visitors, last modified 21 Nov, 2020,
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Attached files

ID Name Comment Uploaded Size Downloads
12709 CKD signs and symptoms.jpg admin 02 Oct, 2019 17:32 73.28 Kb 845
12708 CKD percent function.jpg admin 02 Oct, 2019 17:24 34.03 Kb 872
12707 Causes of CKD.jpg admin 02 Oct, 2019 17:14 18.49 Kb 873
12706 Calcitriol vs CKD stages.jpg admin 02 Oct, 2019 16:38 38.09 Kb 803
8832 Many Faces of Vitamin D in Chronic Kidney.pdf PDF 2017 admin 28 Nov, 2017 15:32 312.51 Kb 558
4869 CKD Race.jpg admin 12 Jan, 2015 02:48 47.27 Kb 8233
4868 CKD incidence.jpg admin 12 Jan, 2015 02:41 32.58 Kb 6863
3374 Dialysis, type of vitamin D, and mortality meta-analysis 2013.pdf PDF - 2013 admin 13 Dec, 2013 02:38 1.38 Mb 1806
3373 Reduced risk of death if any vitamin D.jpg admin 12 Dec, 2013 23:09 57.69 Kb 6813
3371 Meta-analysis Reduced risk of death of get any vitamin D therapy - 2013.pdf admin 12 Dec, 2013 23:07 200.93 Kb 2114
1456 Vicious circle kidney.jpg admin 17 Jul, 2012 16:56 5.14 Kb 8057
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