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Overview Kidney and vitamin D

See also VitaminDWiki


See also web

  • This Vitamin STOPS Proteinuria Fast & REPAIR KIDNEY! (Vitamin D) 9-minute video Jan 2024
  • Vitamin D/VDR in acute kidney injury: a potential therapeutic target - Nov 2020 -doi: 10.2174/0929867327666201118155625
  • Clinical Trials kidney and Vitamin D INTERVENTION 206 trials as of Feb 2024
  • Clinical Trials (kidney OR dialysis) AND "vitamin d" 674 studies Feb 2024
    • "There is not enough evidence showing that one type of active vitamin D is better than another, but there is much difference between their costs." More studies needed
  • Editorial over the Many Faces of Vitamin D in Chronic Kidney Disease: from Mineral to Immune-Inflammatory Modulator - Nov 2017
    "Taken together, the findings of Zhao et al. confirm the immune-inflammatory modulating capacity of vit D and expand the molecular basis to further explore its therapeutic potential in CKD"
     Download the PDF from VitaminDWiki__
  • Preserved circannual rhythm of vitamin D in kidney transplant patients. Sept 2012
    Incredibly Kidney transplant patients are advised to avoid sun exposure because of their high risk of skin cancer.
  • Arrhythmias in chronic kidney disease 2011
    "The arrhythmia burden of the patient with CKD is high, with the single greatest contributor to mortality in end stage renal disease (ESRD) being sudden cardiac death (SCD)"
  • Magnesium – its role in CKD. Nefrologia, May 2013, full text online
    Magnesium for treatment of hyperphosphataemia in patients with chronic kidney disease
  • Dialysis Takes a Toll Dec 2013 New York Times
    Huge health problems with dialysis. No mention of vitamin D
    References a RCT of Dialysis. More of the group which which was randomly assigned to delayed dialysis (7 months) survived
  • Vitamin D supplementation and mortality risk in chronic kidney disease: a meta-analysis of 20 observational studies. PDF at bottom of this page
    Compares different types of vitamin D - no analysis of Magnesium, etc.
  • Treatment Failure of Active Vitamin D Therapy in Chronic Kidney Disease: Predictive Factors Sept 2015
    ". . . up to 50% of patients may experience treatment failure eventually because of development of hypercalcemia or resistant SHPT, characterized by an elevated intact PTH (iPTH) level despite treatment"
    "We propose a definition of vitamin D treatment failure as iPTH >600 pg/ml after 6 months of intravenous active vitamin D treatment and corrected total calcium serum levels >10.2 mg/dl,. .
  • Patient Voices: Kidney Disease New York Times Jan 2018
    Affecting nearly 30 million in the United States
    " chronic kidney disease can be caused by diabetes, chronic hypertension, a genetic factor or a rare disease"
  • Vitamin D treatment and mortality in chronic kidney disease: a systematic review and meta-analysis. 2013 PDF at bottom of this page
    14 studies, 195,000 patients, Risk of death reduced 49% if had gotten ANY AMOUNT of ANY KIND of vitamin supplementation
    Imagine how many fewer deaths if had gotten the right amount of the right kind of vitamin D, along with Magnesium


Kidney is one of only 2 ways that vitamin D is activated in the body

A guess (based on NO data) 50% of vitamin D is activated by the kidneys

VitaminDWiki - Vitamin D Deficiency Vicious circles

Low vitamin D ==> Diabetes ==> Kidney failure
Kidney failure ==> Low Vitamin D and poor regulation of Magnesium
Activated vitamin D decreases with worsening of CKD

Incidence of Chronic Kidney Disease - US

Perhaps 120% increase incidence in a decade

Dark skinned people (with less vitamin D) have 3X more incidence of CKD

Click on chart for more information

Causes of CKD


Only 15% kidney function remains by stage 5


CKD signs and symptoms


Factoids from The Body by Bill Bryson, 2019

  • It remains something of a mystery even now as to why we have two kidneys.
  • The kidneys process about 190 quarts of water and 3.3 pounds of salt. daily
  • Between the ages of forty and seventy, kidney filtration capacity drops by about 50 percent.

Associations with Kidney: Calcitriol 16 Intervention 13 Meta-analysis 13 Diabetes 12 Cardiovascular 12 Skin - Dark 8 Top news 7 Intervention - non daily 6 Genetics 6 Virus 5 Infant-Child 5 Magnesium 5 etc.

and    4 each of Calcidiol High-Dose Vitamin D3 instead of D2 Deficiency How much Vitamin D Vitamin K Tests Vitamin D Receptor Inflammation Vit D Binding Protein Hypertension as of Feb 2024

Overview Kidney and vitamin D        
68918 visitors, last modified 11 Feb, 2024,
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Attached files

ID Name Comment Uploaded Size Downloads
12709 CKD signs and symptoms.jpg admin 02 Oct, 2019 73.28 Kb 2584
12708 CKD percent function.jpg admin 02 Oct, 2019 34.03 Kb 2546
12707 Causes of CKD.jpg admin 02 Oct, 2019 18.49 Kb 2443
12706 Calcitriol vs CKD stages.jpg admin 02 Oct, 2019 38.09 Kb 2426
8832 Many Faces of Vitamin D in Chronic Kidney.pdf admin 28 Nov, 2017 312.51 Kb 1257
4869 CKD Race.jpg admin 12 Jan, 2015 47.27 Kb 9877
4868 CKD incidence.jpg admin 12 Jan, 2015 32.58 Kb 8526
3374 Dialysis, type of vitamin D, and mortality meta-analysis 2013.pdf admin 13 Dec, 2013 1.38 Mb 2382
3373 Reduced risk of death if any vitamin D.jpg admin 12 Dec, 2013 57.69 Kb 8342
3371 Meta-analysis Reduced risk of death of get any vitamin D therapy - 2013.pdf admin 12 Dec, 2013 200.93 Kb 2549
1456 Vicious circle kidney.jpg admin 17 Jul, 2012 5.14 Kb 9619