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Tuberculosis still associated with low vitamin D – 12th meta-analysis June 2021

Impact of vitamin D status and cathelicidin antimicrobial peptide on adults with active pulmonary TB globally: A systematic review and meta-analysis

PLoS One. 2021 Jun 11;16(6):e0252762. doi: 10.1371/journal.pone.0252762. eCollection 2021.
Ester Lilian Acen 1, Irene Andia Biraro 2 3, William Worodria 4, Moses L Joloba 5, Bill Nkeeto 6, Joseph Musaazi 7, David Patrick Kateete 5

VitaminDWiki

Overview Tuberculosis and Vitamin D has the following summary

There are many indications that vitamin D both PREVENTS and TREATS TB

  • As with many other diseases, we expect that there will be at least a 4X range of vitamin D due to:
    • 4X range in the response in the vitamin D blood level for the same IU dose - for healthy, non-obese, people
  • Also expect that co-factors and Vitamin D Receptor activators will prove to be very important
  • UV appears to be as powerful or perhaps more powerful than vitamin D in TREATING TB
TB and vitamin D 112 items

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Items in both categories TB and Meta-analysis are listed here:


A Poor Vitamin D Receptor prevents Vitamin D in blood from getting to the cells

The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

Items in both categories TB and Vitamin D Receptor:

 Download the PDF from VitaminDWiki
Standard mean differences of Vitamin D and TB
Image

Background: Tuberculosis remains a global threat and a public health problem that has eluded attempts to eradicate it. Low vitamin D levels have been identified as a risk factor for tuberculosis infection and disease. The human cathelicidin LL-37 has both antimicrobial and immunomodulatory properties and is dependent on vitamin D status. This systematic review attempts to compare vitamin D and LL-37 levels among adult pulmonary tuberculosis patients to non-pulmonary TB individuals between 16-75 years globally and to determine the association between vitamin D and cathelicidin and any contributing factor among the two study groups.

Methods/design: We performed a search, through PubMed, HINARI, Google Scholar, EBSCOhost, and databases. A narrative synthesis through evaluation of vitamin D and LL-37 levels, the association of vitamin D and LL-37, and other variables in individual primary studies were performed. A random-effect model was performed and weighted means were pooled at a 95% confidence interval. This protocol is registered under the International Prospective Register of Systematic Reviews (PROSPERO), registration number CRD42019127232.

Results: Of the 2507 articles selected 12 studies were eligible for the systematic review and of these only nine were included in the meta-analysis for vitamin D levels and six for LL-37 levels. Eight studies were performed in Asia, three in Europe, and only one study in Africa. The mean age of the participants was 37.3±9.9 yrs. We found low vitamin D and high cathelicidin levels among the tuberculosis patients compared to non-tuberculosis individuals to non-tuberculosis. A significant difference was observed in both vitamin D and LL-37 levels among tuberculosis patients and non-tuberculosis individuals (p = < 0.001).

Conclusion: This study demonstrated that active pulmonary tuberculosis disease is associated with hypovitaminosis D and elevated circulatory cathelicidin levels with low local LL-37 expression. This confirms that vitamin D status has a protective role against tuberculosis disease.


Created by admin. Last Modification: Saturday June 12, 2021 01:31:34 GMT-0000 by admin. (Version 12)

Attached files

ID Name Comment Uploaded Size Downloads
15737 TB Meta.jpg admin 12 Jun, 2021 01:29 25.77 Kb 48
15736 Cod liver TB - 1848.pdf admin 12 Jun, 2021 01:11 644.92 Kb 51
15734 TB Meta.pdf PDF 2021 admin 12 Jun, 2021 01:00 1.34 Mb 45
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