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Alzheimer's 9X more likely in women with a poor Vitamin D receptor – Sept 2022

Association of vitamin D receptor gene haplotypes with late-onset Alzheimer's disease in a Southeastern European Caucasian population

Exp Ther Med. 2022 Jul 19;24(3):584 doi: 10.3892/etm.2022.11521
Efthimios Dimitrakis 1 , Martha-Spyridoula Katsarou 1 , Maria Lagiou 1 , Vasiliki Papastefanopoulou 2 , Demetrios A Spandidos 3 , Aristidis Tsatsakis 4 , Socratis Papageorgiou 5 , Paraskevi Moutsatsou 2 , Katerina Antoniou 6 , Christos Kroupis 2 , Nikolaos Drakoulis 1

Note: 4X increase for men
Vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) have been investigated over the past years with the aim of identifying any association with the development of Alzheimer's disease (AD). However, information regarding the potential association of VDR SNP haplotypes with AD is limited. The aim of the present study was to provide additional knowledge on the effects of VDR haplotypes on the development of late-onset AD in a cohort of Southeastern European Caucasians (SECs). The study sample included 78 patients with late-onset AD and 103 healthy subjects as the control group. VDR SNPs that were analyzed were TaqI (rs731236), BsmI (rs1544410) and FokI (rs2228570).

  • The CAC (TaqI, BsmI and FokI) haplotype was found to be associated with a 53% lower risk of developing the disease (OR, 0.47; 95% CI, 0.23-0.96; P=0.04) and the
  • TAC (TaqI, BsmI and FokI) haplotype was associated with an ~6-fold greater risk of developing AD (OR, 6.19; 95% CI, 1.91-20.13; P=0.0028).
  • Female subjects carrying the TAC haplotype had a ~9-fold greater risk of developing AD in comparison to female control subjects (OR, 9.27; 95% CI, 1.86-46.28; P<0.05).

The TaqI and BsmI polymorphisms were in high linkage disequilibrium (D'=0.9717, r=0.8467) and produced a haplotype with a statistically significant different frequency between the control and AD group.

  • The TA (TaqI and BsmI) haplotype was associated with an ~8-fold greater risk of developing AD (OR, 8.27; 95% CI, 2.70-25.28; P<0.05).
  • Female TA carriers had an ~14-fold greater risk of developing the disease in comparison to female control subjects (OR, 13.93; 95% CI, 2.95-65.87; P<0.05).

On the whole, the present study demonstrates that in the SEC population, TAC and TA are risk haplotypes for AD, while the CAC haplotype may act protectively. SEC women carrying the TAC or TA haplotype are at a greater risk of developing AD, thus suggesting that women are markedly affected by the poor utilization of vitamin D induced by the VDR haplotype.
 Download the PDF from VitaminDWiki

Vitamin D Receptor pages with ALZHEIMER in title (12 as of Aug 2022)

This list is automatically updated

Items found: 12

VitaminDWiki - Overview Alzheimer's-Cognition and Vitamin D contains

Alzheimer's Disease increased risk with poor genes

Alzheimer's genes: Are you at risk? Mayo Clinic

  • "Having at least one APOE e4 gene increases your risk of developing Alzheimer's disease two- to threefold. If you have two APOE e4 genes, your risk is even higher, approximately eight- to twelvefold , , , "

Alzheimer disease risk genes: 29 and counting - March 2019  PDF from Sci-Hub

  • Note: Neither VDR, Receptor nor Vitamin occur even once in the PDF

Note: Some diseases, such as COVID and Breast Cancer, actively decrease activation of the VDR

I am unaware of any hint that Alzheimer's decreases VDR activation
There may, however, be an increase in Alzheimer's due to Long-COVID

Created by admin. Last Modification: Thursday August 11, 2022 23:40:35 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
18274 Alx VDR genes.pdf admin 11 Aug, 2022 522.54 Kb 230
18273 9X 6 percent females.jpg admin 11 Aug, 2022 30.37 Kb 290
18272 .Alzheimer's VDR.pdf admin 11 Aug, 2022 274.06 Kb 163