Loading...
 
Translate Register Log In Login with facebookLogin and Register

Respiratory Distress Syndrome in preemies 5 X more likely if poor vitamin D receptor – Feb 2019

Association of vitamin D receptor gene FokI and TaqI polymorphisms and risk of RDS.

J Matern Fetal Neonatal Med. 2019 Feb 13:1-201. doi: 10.1080/14767058.2019.1582629.
Ustun N1, Eyerci N2, Karadag N1, Yesilyurt A2, Zenciroglu A1, Okumus N1.
1 Neonatology Dr Sami Ulus Maternity and Children's Training and Research Hospital , Ankara , Turkey.
2 Dept of Genetics , Dıskapı Yıldırım Beyatız Education and Training Hospital , Ankara , Turkey.

VitaminDWiki

Vitamin D Receptor category has the following

300 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population has a poor VDR (40% of the Obese )

A poor VDR increases the risk of 53 health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentation Vitamin D
Increases the concentration gradient
Vitamin D in the cells

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR

Items in both categories VDR and Infants are listed here:

Items in both categories VDR and Breathing are listed here:

 Download the PDF fromSci-Hub via VitaminDWiki
Image

BACKGROUND:
Vitamin D and its receptor (VDR) have important roles in perinatal lung development. The objective of this study was to investigate the possible association between VDR FokI and TaqI polymorphism and development of respiratory distress syndrome (RDS) in preterm infants.

METHOD:
A total of 173 premature infants < 34 weeks: 82 with RDS and 91 without RDS were enrolled. Genotyping of VDR polymorphisms were assayed by real-time PCR. Serum 25-hydroxyvitamin D (25-OHD) levels were measured by ELISA in blood samples that were obtained at the time of admission to the neonatal intensive care unit.

RESULTS:
Gestational age (GA) was significantly lower in RDS group compared to the controls. In univariate analysis, VDR TaqI CT and CC genotypes were associated with the increased risk of RDS (OR = 3.264, p = 0.001, 95% CI = 1.597-6.672 and OR = 5.222, p < 0.001, 95% CI = 2.165-12.597, respectively); while VDR FokI showed no association with RDS. 25-OHD levels in RDS group were significantly lower compared with those in without RDS group (p = 0.002). Serum 25-OHD levels were not significantly different among the different FokI and TaqI genotypes.

CONCLUSIONS:
This is the first report of association of VDR polymorphism with RDS development in preterm neonates. Current study suggests that VDR TaqI polymorphism may be involved in predisposition to RDS in premature neonates. Further studies are needed to assess the contribution of vitamin D and VDR signaling to the pathogenesis RDS.

Created by admin. Last Modification: Sunday March 3, 2019 10:33:04 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
11392 RDS T2.jpg admin 15 Feb, 2019 13:39 86.83 Kb 40
11391 RDS.pdf PDF 2019 admin 15 Feb, 2019 13:39 904.39 Kb 26
See any problem with this page? Report it (FINALLY WORKS)