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Autism 2X more likely if poor Vitamin D Receptor (yet again) – meta-analysis Jan 2020

The Correlation Between Vitamin D Receptor (VDR) Gene Polymorphisms and Autism: A Meta-analysis

J Mol Neurosci, 2020 Jan 3, PMID: 31900887 DOI: 10.1007/s12031-019-01464-z
Hongchang Yang 1 2, Xueping Wu 3 4

VitaminDWiki

Autism 2X more likely with Vitamin D Receptor problems – many studies
Vitamin D Receptor is associated in over 40 autoimmune studies
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

Autism category in VitaminDWiki starts with

Autism category has 133 items

 - see also Overview Autism and vitamin D,  Autoimmune ,   Cognitive,    ADHD
Interesting Autistic studies
Autism associated with low Vitamin D

Autism treated by Vitamin D

Autism reduced by vitamins before and during pregnancy

Autism and Vitamin D Receptor (not enough Vit D to the tissues)

Autism - other risk factors

Vaccines increase the risk

Dr. Cannell on Autism and Vitamin D

Vitamin D receptor (VDR) polymorphisms are risk factors for autism. We performed a systematic meta-analysis to explore the relationship between VDR gene polymorphisms and autism. A literature review of articles from Pubmed, Embase, the Cochrane Library, and Springer was conducted up to January 28, 2019. The association between SNPs and autism was calculated using pooled odd ratios (ORs) and 95% confidence intervals (CIs). Additionally, tests for heterogeneity, publication bias, and sensitivity were conducted. Six eligible studies with a total of 2001 participants (1045 cases and 956 controls) were included.
Meta-analysis indicated that the "C" allele of the rs731236 gene, including

  • C vs. T (OR = 1.3254, 95% CI = 1.0897-1.6122),
  • CC vs. TT (OR = 2.0871, 95% CI = 1.3395-3.2519), and
  • CC vs. TT + CT (OR = 1.9610, 95% CI = 1.2985-2.9615),

might be a risk factor for autism. Moreover, the "G" allele of rs7975232 (G vs. T: OR = 0.8228, 95% CI = 0.6814-0.9934) was associated with a protective effect against the development of autism. No significant differences were found in the allele frequencies of rs11568820, rs1544410, and rs2228570 in the cases and controls. This meta-analysis revealed that both VDR rs731236 and rs7975232 were significantly associated with autism, whereas VDR rs11568820, rs1544410, and rs2228570 might not be correlated with the incidence of autism.


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