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Disc Degeneration in women is 1.7X more likely if poor Vitamin D Receptor – meta-analysis Jan 2017

Association Between the FokI and ApaI Polymorphisms in the Vitamin D Receptor Gene and Intervertebral Disc Degeneration: A Systematic Review and Meta-Analysis.

Genet Test Mol Biomarkers. 2017 Jan;21(1):24-32. doi: 10.1089/gtmb.2016.0054. Epub 2016 Oct 31.
Pabalan N1, Tabangay L2, Jarjanazi H3, Vieira LA4, Dos Santos AA5, Barbosa CP5, Rodrigues LM4, Bianco B5.
1 Center for Research and Development, Angeles University Foundation , Angeles City, Philippines .
2 Department of Biological Sciences, Angeles University Foundation , Angeles City, Philippines .
3 Environmental Monitoring and Reporting Branch, Ontario Ministry of the Environment and Climate Change , Etobicoke, Canada .
4 Orthopedics and Traumatology, Faculdade de Medicina do ABC-Santo André , São Paulo, Brazil .
5 Department of Collective Health, Faculdade de Medicina do ABC, Human Reproduction and Genetics Center , São Paulo, Brazil .


Items in both categories Osteoporosis and Vitamin D Receptor are listed here:

Items in both categories Back Pain and Vitamin D Receptor are listed here:

Vitamin D Receptor category has the following

209 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

A poor VDR increases the risk of 41 health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:

1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor

See chart at the bottom of VDR page for Magnesium, Omega-3 and Resveratrol

If poor Vitamin D Receptor

Health Problem
9.6Chronic Periodontitis
   and smoke
7.6Crohn's disease
7.5Respiratory Tract Infections
5.8Low back pain in athletes
5Ulcerative Colitis
5Coronary Artery Disease
4.6Breast Cancer
4polycystic ovary syndrome
3.3 Pre-term birth
3.1 Colon Cancer survival
3 Multiple Sclerosis
3 Waist size
3 Ischemic Stroke
2.8Osteoporosis & COPD
2.7Gastric Cancer
2.6Lupus in children
2.5 Lumbar Disc Degeneration
2.4Lung Cancer
2.1Adolescent idiopathic scoliosis in Asians
2Diabetic Retinopathy
2 Wheezing/Asthma
2 Melanoma   Non-melanoma Skin Cancers
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.4 Rheumatoid arthritis
1.3Childhood asthma

See also PubMed

 Download the PDF from VitaminDWiki

Evidence supporting an association of intervertebral disc degeneration (DD) with polymorphisms of the vitamin D receptor (VDR) gene has been controversial. We performed a meta-analysis of these studies to determine if there was substantial evidence to support such an association between the VDR polymorphisms and DD.

PubMed, Embase, and Science Direct databases were searched for studies that investigated associations of the FokI (rs2228570, rs10735810), and ApaI (rs7975253) polymorphisms of the VDR gene with DD. From the extracted genotype data from 14 publications, we estimated risk (odds ratio OR with 95% confidence intervals).

Overall associations of FokI with DD were absent (OR 0.96-1.04, p = 0.73-0.95) with heterogeneity in the dominant and codominant models (pheteroegeneity <0.10, I2 = 47-57%). Post-outlier pooled effects yielded dominant significance indicating reduced risk (OR 0.77, p = 0.01) with concomitant zero heterogeneity (I2 = 0%). ApaI effects pointed to reduced risks, with overall dominant significance (OR 0.69, p = 0.04) and Asian subgroup nonsignificance (OR 0.75-0.93, p = 0.17-0.74). In FokI, Non-Hispanic Caucasians (OR 0.77, p = 0.01) and males (OR 0.36-0.66, p = 0.001-0.04) were protected but not Hispanic Caucasians (OR 1.39-1.85, p = 0.006-0.05) and females (OR 1.72, p = 0.05). Tests of interaction between the genders highlighted female susceptibility and male protection (p = 0.001-0.005). Zero heterogeneity (I2 = 0%) is a key strength of these significant effects.

This meta-analysis confirmed the protective role of the ApaI polymorphism, however, susceptibility and protective effects of the FokI polymorphism may be ethnic and gender specific.

PMID: 27797588 DOI: 10.1089/gtmb.2016.0054

Created by admin. Last Modification: Sunday February 4, 2018 10:24:18 UTC by admin. (Version 10)

Attached files

ID Name Comment Uploaded Size Downloads
9301 VDR Lumbar 2016.pdf admin 04 Feb, 2018 10:23 902.81 Kb 15
9300 VDR Osteoporosis 2018.pdf PDF 2018 admin 04 Feb, 2018 10:14 3.28 Mb 20
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