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Sepsis in infants 4.8 X more likely if poor vitamin D receptor – March 2018

Vitamin D Deficiency and Vitamin D Receptor Variants in Mothers and Their Neonates Are Risk Factors for Neonatal Sepsis.

Steroids. 2018 Mar 9. pii: S0039-128X(18)30054-0. doi: 10.1016/j.steroids.2018.03.003.
Tayel SI1, Soliman SE2, Elsayed HM3.
1 Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Egypt. drsafaa_tayel at yahoo.com.
2 Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Egypt.
3 Pediatric Medicine Departments, Faculty of Medicine, Menoufia University, Egypt.

VitaminDWiki

Sepsis is both prevented and treated by Vitamin D starts with

Summary of Sepsis and Vitamin D

  • Sepsis more likely in those with poor immune systems
    Infants, elderly, sick, those with low vitamin D
  • Severe Sepsis has been associated with low vitamin D in many studies
  • Vitamin D treats Sepsis (RCT- 2015, below)
      Reduced: ICU by 8 days, Hospital stay by 7 days, and readmission rate to 0%
  • Many studies have found that a high level of Vitamin D also prevents Sepsis

VitaminDWiki recommendations for Vitamin D treatment of Sepsis in ICU

  1. Fortify the immune system as fast as possible ( Vitamin D Loading dose = Stoss dose = Bolus dose )
  2. Speedup the restoration of Vitamin D with sublingual or topical vitamin D
    • Nanoemulsion form of Vitamin D seems particularly fast acting
  3. Follow loading dose with maintenance doses of vitamin D - probably 50,000 IU weekly
    • Note: Many studies incorrectly used no maintenance dosing, just loading dose
  4. Consider reducing Sepsis even more by adding:   Omega-3    Magnesium    Glutamine

Items in both categories Infant-child and Vitamin D Receptor are listed here:

Vitamin D Receptor category has the following

469 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 44 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor.Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (17 studies), Breast Cancer (20 studies), Colon Cancer (13 studies), Cardiovascular (22 studies), Cognition (16 studies), Diabetes (22 studies), Hypertension (7 studies), Infant (18 studies), Lupus (6 studies), Metabolic Syndrome (3 studies), Mortality (4 studies), Multiple Sclerosis (11 studies), Obesity (15 studies), Pregnancy (22 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (30 studies),   Click here for details
Some health problems, such as Breast Cancer and Diabetes, protect themselves by reducing VDR activation
Suspect that SAR-COV-2 also protects itself from Vitamin D

55 health problems associated with poor VDR


A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR


How to increase VDR activation


Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14)Butyrate especially gutVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR


Increased risk associated with a poor Vitamin D Receptor
   Note: Some diseases reduce VDR activation
those with a * are known to decrease activation

Risk
increase
Health Problem
50Lyme Disease *
28Leprosy - another says 3X
15Chronic Heart Failure
15Temporary hair loss
14,7Childhood solid cancers
14Hand, Foot, and Mouth disease
13Sepsis
12COIVD Death
11Metabolic Syndrome
9.6Chronic Periodontitis
   and smoke
8Juvenile Rheumatoid Arthritis
7.6Crohn's disease
7.5Respiratory Tract Infections
5.8Low back pain in athletes
5 Respiratory Distress in preemies
5Ulcerative Colitis
5Coronary Artery Disease
5Asthma Child see also 1.3, 2.0 and 3.6
4.6Breast Cancer * 16.9 X another study
4.3Severe COVID in kids
4.1Vitiligo
4Polycystic ovary syndrome
3.8Lupus
3.6 Pneumonia - children
3.3 Pre-term birth
3.1 Colon Cancer survival
3 Multiple Sclerosis
3Dengue
3 Waist size
3 Ischemic Stroke
3Alzheimer’s
9X in women
3Parkinson’s
3Gestational Diabetes
2.9Hand, Foot, Mouth Disease
2.8Osteoporosis & COPD
2.7Gastric Cancer
2.6Lupus in children
2.5 Lumbar Disc Degeneration
2.4Lung Cancer
2.3Cardio
2.3Autism
2.2Juvenile idiopathic arthritis
2.1Adolescent idiopathic scoliosis in Asians
2Diabetic Retinopathy
2Parkinson's
2 Wheezing/Asthma see also 5X
2 Melanoma   Non-melanoma Skin Cancers
2Myopia
2Preeclampsia
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.8Sleep Apnea
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.5Gout
1.5Pertussis
1.5Obesity
1.4Graves Disease
1.4 Rheumatoid arthritis
1.3Hypertension
1.3Childhood asthma see also 5X
1.3Psoriasis in Caucasians
1.3Tuberculosis
?? Rickets - Vitamin D resistant


BACKGROUND AND AIM:
increasing prevalence of neonatal sepsis in recent years catch attention to early prevention and management. Vitamin D receptor (VDR) polymorphism can modulate VDR expression level that greatly influences immunity and susceptibility to microbial infections. We aimed to investigate the association of VDR polymorphism at FokI, rs2228570 T/C, and TaqI, rs731236 C/T gene with serum 25-hydroxyvitamin D level and risk of neonatal sepsis.

METHODS:
This work carried on 160 subjects classified into 80 cases (40 mothers and their 40 septic neonates) and 80 healthy controls (40 volunteer mothers and their 40 healthy neonates). Genotyping of VDR polymorphisms were assayed by real- time PCR and serum 25-hydroxyvitamin D level and hs-CRP were measured by ELISA.

RESULTS:
Vitamin D deficiency was observed in mothers of cases compared with healthy ones (p=<0.001) and in septic neonates versus healthy ones (p=<0.001).
Septic neonates had much higher VDR FokI TT genotype (p=0.014) and T allele (p=0.003) versus healthy ones.

  • TT genotype and T allele could increase the risk of sepsis with OR 95% CI [4.804 (1.4-16.4)] and 2.786 (1.4-5.7) respectively

while VDR TaqI showed no association with sepsis. There was a strong LD between FokI and TaqI in sepsis cases. In sepsis, T/T genotype at FokI had significantly lower vitamin D (p=<0.001).

CONCLUSION: Vitamin D deficiency in mothers/neonates is a risk factor for neonatal sepsis. VDR FokI T allele had lower 25-hydroxyvitamin D level that may predispose to sepsis hazards.

PMID: 29530503 DOI: 10.1016/j.steroids.2018.03.003


Created by admin. Last Modification: Thursday June 27, 2019 11:29:28 GMT-0000 by admin. (Version 5)